亲环蛋白A和CD147与肾脏疾病研究进展
Research Progress of Cyclophilin A and CD147 in Kidney Diseases
DOI: 10.12677/ACM.2022.123221, PDF,    国家自然科学基金支持
作者: 陶 丽, 苏 华*：华中科技大学同济医学院附属协和医院肾内科，湖北 武汉
关键词: 亲环蛋白A；CD147；肾脏疾病；肾细胞癌；Cyclophilin A； CD147； Kidney Disease； Renal Cell Carcinoma
摘要: 亲环蛋白A (cyclophilin A, CypA)在体内普遍表达，主要位于细胞内，在受到感染、缺氧和氧化应激等刺激时，可以分泌到各种细胞类型的细胞外环境中。CD147是一种广泛表达的糖基化跨膜蛋白。目前一些研究证实CD147为CypA的细胞表面受体，CD147是CypA启动的信号级联中的重要组成部分。CypA和CD147及其相互作用在人类疾病中的作用越来越受到关注。最近的研究数据表明，CypA和CD147在肾脏疾病的发生发展中具有重要作用。本文围绕CypA和CD147在糖尿病肾病、急性肾损伤、肾纤维化、狼疮肾炎、肾细胞癌等肾脏疾病中的表达和功能展开综述，期望对肾脏疾病的诊断和治疗提供新的线索。
Abstract: Cyclophilin A (CypA) is ubiquitously expressed in vivo, mainly locates in intracellular, and can be secreted into the extracellular environment of various cell types when stimulated by infection, hypoxia and oxidative stress. CD147 is a widely expressed glycosylated transmembrane protein. At present, some studies have confirmed that CD147 is the cell surface receptor of CypA, and CD147 is an important part of the signaling cascade initiated by CypA. The role of CypA and CD147 and their interactions in human diseases have received increasing attention. Recent research data indicate that CypA and CD147 play an important role in the occurrence and development of kidney diseases. This review focuses on the expression and function of CypA and CD147 in diabetic kidney disease, acute kidney injury, renal fibrosis, lupus nephritis, renal cell carcinoma and other renal diseases, hoping to provide new clues for the diagnosis and treatment of kidney diseases.
文章引用：陶丽, 苏华. 亲环蛋白A和CD147与肾脏疾病研究进展[J]. 临床医学进展, 2022, 12(3): 1529-1538. https://doi.org/10.12677/ACM.2022.123221

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