慢性肾脏病肌肉减少症:机制和治疗
Sarcopenia in Chronic Kidney Disease: Mechanism and Treatment
DOI: 10.12677/ACM.2022.123231, PDF,   
作者: 李嘉琪, 谭荣韶*:暨南大学附属广州红十字会医院,广东 广州
关键词: 慢性肾脏病肌肉减少症肌肉萎缩Chronic Kidney Disease Sarcopenia Muscle Atrophy
摘要: 在慢性肾脏病(chronic kidney disease, CKD)患者中,经常出现骨骼肌萎缩和蛋白质能量消耗。肌肉功能的损失会导致生活质量下降、发病率和死亡率增加。蛋白质降解与合成之间的持续不平衡会导致肌肉萎缩,在代谢性疾病如CKD,在肌肉中检测出的炎症增加、卫星细胞功能障碍以及尿毒素的积累可以激活泛素–蛋白酶体系统(ubiquitin-proteasome system, UPS),促进肌生长抑制素导致骨骼肌质量损失。因此,及早发现、诊断及防治肌少症对提高CKD患者的生存质量至关重要。本文就CKD肌少症的机制和治疗进行综述。
Abstract: Skeletal muscle atrophy and protein energy wasting are frequent in patients with chronic kidney disease (CKD). Loss of muscle function leads to the decreased quality of life and increased morbidity and mortality. A persistent imbalance between protein degradation and synthesis can lead to muscle atrophy, and in metabolic diseases such as CKD, increased inflammation, satellite cell dysfunction, and accumulation of urea toxins detected in muscle can activate the ubiquitin-proteasome system (UPS) that promotes myostatin leading to loss of skeletal muscle mass. Therefore, early detection, diagnosis and prevention of sarcopenia are essential to improve the quality of life of CKD patients. This article reviews the mechanism and treatment of sarcopenia in CKD.
文章引用:李嘉琪, 谭荣韶. 慢性肾脏病肌肉减少症:机制和治疗[J]. 临床医学进展, 2022, 12(3): 1607-1617. https://doi.org/10.12677/ACM.2022.123231

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