壳聚糖–海藻酸钠–丹参酮IIA微球的制备及其工艺优化

Preparation and Process Optimization of Chitosan-Sodium Alginate-Tanshinone IIA Microspheres

摘要: 目的：优化壳聚糖–海藻酸钠(CS-SA)包裹丹参酮IIA (TIIA)的工艺条件，得到最佳工艺。方法：研究海藻酸钠含量、壳聚糖含量、Ca²⁺含量、Span-80等工艺条件对微球粒径分布的影响，在此基础上，研究SA、CS、Ca²⁺含量对载药量的影响，以工艺参数进行优化。结果：最佳工艺条件：SA含量为1.5%、Ca²⁺含量30%、CS含量0.4%，在该最佳工艺条件下，最大载药量达到13.2%。结论：为CS-SA包裹TIIA工业化生产应用提供了方向。

Abstract: Objective: The research aimed to optimize the process conditions of tanshinone IIA (TIIA) encapsulated by chitosan-sodium alginate (CS-SA) and obtain the best process. Method: The effects of sodium alginate content, chitosan content, Ca²⁺ content, Span-80 and other process conditions on the particle size distribution of microspheres were studied. On this basis, the effects of SA, CS and Ca²⁺ content on drug loading were studied. The process parameters were optimized. Result: The optimal process conditions: SA content was 1.5%, Ca²⁺ content was 30%, CS content was 0.4%. Under the optimal process conditions, the maximum drug loading amount reached 13.2%. Conclusion: It provides a direction for the industrial production and application of CS-SA wrapped TIIA.