2型糖尿病合并阻塞性睡眠呼吸暂停综合征的共病机制研究综述

A Review of Comorbidity Mechanisms of Type 2 Diabetes Mellitus with Obstructive Sleep Apnea Syndrome

摘要: 目前在2型糖尿病(type 2 diabetes mellitus, T2DM)患者中，阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome, OSAS)的患病率日益增加，两病的共病人群血糖、血脂、血压、BMI等多项体检指标控制差，且有更高心脑血管危险性，炎症与氧化应激(oxidative stress, OS)、肥胖与内脏脂肪沉积、神经损害、下丘脑–垂体–肾上腺轴活性改变和脂质代谢紊乱是目前多项研究中与两种疾病共病相关的机制。为了更好地管理共病患者，探究两种疾病共病机制有充分的必要性。本综述旨在归纳总结2型糖尿病合并阻塞性睡眠呼吸暂停综合征共病机制的相关文献，对共病相关可能机制的研究证据进行总结归纳。

Abstract: At present, in T2DM patients, the prevalence of OSAS is increasing day by day. The co-patients of the two diseases have poor control of blood glucose, blood lipids, blood pressure, BMI and other physical indicators, and higher risk of cardiovascular and cerebrovascular diseases. Inflammation and oxidative stress, obesity and visceral fat deposition, nerve damage, changes in activity of hypothalamic-pituitary-adrenal axis and lipid metabolism disorder are the mechanisms associated with the co-morbidity of the two diseases in many studies. In order to manage comorbidity better, it is necessary to explore the comorbidity mechanism of the two diseases. The purpose of this review is to summarize the literature on the mechanism of comorbidities of type 2 diabetes mellitus with obstructive sleep apnea syndrome, and to summarize the research evidence on the possible mechanisms of comorbidities.