miRNA调控阿尔茨海默症患者认知功能研究进展
Advances in miRNA Regulation of Cognitive Function in Alzheimer’s Disease Patients
摘要: 阿尔茨海默病(Alzheimer’s disease, AD)是最普遍的神经系统退行性疾病，由于其高发病率和残疾率，AD已经变成了一种严峻的社会和公共卫生问题。尽管如此，AD的病因仍然未知，虽然人们普遍认为它与遗传和环境因素有关，但没有任何药物可以有效逆转认知缺陷。国内外研究发现miRNA (microRNA)被认为是阿尔茨海默病的重要调节因子和治疗靶点，参与并且干预其表达可改善AD的认知功能，其中miR-19b-3p、miR-16-5p、miR-132、miR-15a等发挥着重要的作用。文章总结近年来的阿尔兹海默症病理机制研究结果，从国内外研究进展进行综述。期待为临床治疗AD提供有效的治疗策略。
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative illness, and its high incidence and impairment rates have made it a severe socio-economic and public health issue. The cause of AD remains unknown, however, and although it is widely believed to be linked to genetic and environmental factors, no drug has been shown to be effective in reversing cognitive impairment. MiRNA (microRNA) has been found to be important modulators and therapeutic targets of Alzheimer’s disease at home and abroad, and their expression can improve the cognitive function of AD, miR-19b-3p, miR-16-5p, miR-132, miR-15a and so on play an important role. This article summarizes the clinical research results of Alzheimer’s disease in recent years, and reviews the research progress at home and abroad. It is anticipated that it will provide a viable therapeutic method for the clinical treatment of Alzheimer’s disease.
文章引用：钱源, 张越林. miRNA调控阿尔茨海默症患者认知功能研究进展[J]. 临床医学进展, 2022, 12(3): 1730-1734. https://doi.org/10.12677/ACM.2022.123249

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