早产儿应用多种油脂肪乳的非特异性炎症、肝功、凝血功能指标分析

Analysis of Non-Specific Inflammation, Liver Function, and Coagulation Function Indexes of Premature Infants Using Various Oil and Fat Emulsions

摘要: 目的：比较早产儿应用多种油脂肪乳(SMOF)与中长链脂肪乳(MCT/LCT)的非特异性炎症、肝功、凝血功能指标，以指导临床应用。方法：回顾性纳入2020年1月1日至2021年9月30日收治的41例早产儿为研究对象，入院时日龄 ≤ 24 h，接受胃肠外营养时间 ≥ 10 d。根据应用的脂肪乳剂种类，分为SMOF组(n = 20)和MCT/LCT组(n = 21)，比较两组患儿间非特异性炎症指标、肝功、凝血功能指标变化。结果：非特异性炎症指标比较，SMOF组的WBC数值下降较MCT/LCT组明显，差异具有统计学意义；肝功能指标比较，SMOF组TBIL数值上升较MCT/LCT组幅度小，差异具有统计学意义；凝血功能指标比较，SMOF组与MCT/LCT组的PT数值存在差异，差异具有统计学意义。结论：SMOF应用于早产儿，具有抗炎、保护肝功能的优势，且对凝血功能影响不大，安全性更高，值得使用推广。

Abstract: Objective: To compare the non-specific inflammation, liver function and coagulation function indexes of SMOF and MCT/LCT in preterm infants to guide clinical application. Methods: The 41 premature infants admitted from January 1, 2020 to September 30, 2021 were retrospectively included as the research objects. The age at admission was ≤ 24 h and the duration of parenteral nutririon was ≥ 10 d. According to the types of fat emulsion received, the preterm infants were divided into two groups: SMOF group (n = 20) and MCT/LCT group (n = 21). Compare the indicator changes of non-specific inflammation indexes, liver function, and coagulation function between the two groups. Results: In the comparison of non-specific inflammation indexes, the WBC value of the SMOF group decreased significantly than that of the MCT/LCT group, and the difference was statistically significant; in the comparison of liver function indexes, the TBIL value of the SMOF group decreased significantly than that of the MCT/LCT group, and the difference was statistically significant. In the comparison of coagulation function indexes, the PT values of SMOF group and MCT/LCT group are different, and the difference is statistically significant. Conclusion: The use of SMOF in premature infants has the advantages of anti-inflammatory and protecting liver function, and has little effect on blood coagulation function, so it has higher safety. It is worthy of promotion.