铁过载在慢性乙型病毒性肝炎中作用的研究进展
Research Progress on the Role of Iron Overload in Chronic Viral Hepatitis B
DOI: 10.12677/ACM.2022.123262, PDF,   
作者: 丁 银, 石宇婧：重庆医科大学附属第二医院，重庆
关键词: 铁过载；机制；肝纤维化；乙型肝炎；Iron Overload； Mechanism； Liver Fibrosis； Hepatitis B
摘要: 慢性乙型病毒性肝炎(Chronic viral hepatitis B)是由于机体感染乙型肝炎病毒引起的，严重危害人类健康的世界性传染性疾病。在慢性乙型肝炎患者中，我们可以观察到铁过载，过量的铁形成非转铁蛋白结合铁(NTBI)，从而产生大量的活性氧(ROS)，导致肝细胞和组织损伤，进而引起肝纤维化。因此，深入了解铁过载在肝纤维化中的作用，从而制定对于CHB患者铁过载的诊断、治疗的有效措施，有助于在纤维化达到不可挽回的阶段前阻止或减缓纤维化进程。本综述主要叙述了铁过载在肝纤维化中的作用，还描述了铁过载在CHB患者疾病进展中的作用。
Abstract: Chronic viral hepatitis B (CHB) is a worldwide infectious disease caused by hepatitis B virus, which seriously harms human health. Iron overload can be observed in patients with chronic hepatitis B, where excess iron forms non-transferrin binding iron (NTBI), resulting in the production of large amounts of reactive oxygen species (ROS), resulting in liver cell and tissue damage, which in turn causes liver fibrosis. Therefore, an in-depth understanding of the role of iron overload in liver fibrosis and the formulation of effective measures for the diagnosis and treatment of iron overload in CHB patients can help prevent or slow down the fibrosis process before fibrosis reaches the irreversible stage. This review focuses on the role of iron overload in liver fibrosis and the role of iron overload in disease progression in CHB patients.
文章引用：丁银, 石宇婧. 铁过载在慢性乙型病毒性肝炎中作用的研究进展[J]. 临床医学进展, 2022, 12(3): 1820-1825. https://doi.org/10.12677/ACM.2022.123262

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