热休克蛋白70在癫痫中的研究进展

Research Progress of Heat Shock Protein 70 in Epilepsy

摘要: 癫痫(Epilepsy)是多种原因引起的脑病神经元异常同步异常放电所致的临床综合征，是最常见的慢性神经系统疾病之一。异常放电神经元位置不同及异常放电波及范围差异，导致患者发作形式多样。目前，癫痫治疗方法有药物治疗、手术切除致痫病灶、迷走神经电刺激等，现有治疗方法以控制癫痫发作频率为主，缺乏预防癫痫发生的神经保护疗法，无法降低耐药性癫痫的发生比例。热休克蛋白(Heat shock proteins, HSPs)是一类分子伴侣蛋白，具有稳定蛋白质结构和功能的作用。大量的研究发现，热休克蛋白70在炎症因子的表达、抑制细胞凋亡、抑制蛋白质聚集、肿瘤、免疫等方面发挥作用，与神经系统疾病的发病机制关系密切。本文就HSP70在癫痫疾病中的研究进展进行概述，以期为HSP70相关制剂在癫痫治疗中的使用提供理论依据。

Abstract: Epilepsy is a clinical syndrome caused by abnormal synchronous abnormal discharge of encephalopathic neurons caused by a variety of reasons, and it is one of the most common chronic nervous system diseases. The different location of abnormal discharge neurons and the different range of abnormal discharge affect lead to the various forms of patients’ attacks. Currently, the treatment methods for epilepsy include drug therapy, surgical resection of epileptic foci and electrical stimulation of vagus nerve, etc. The existing treatment methods mainly control the frequency of epileptic seizures, but lack neuroprotective therapy to prevent the occurrence of epilepsy, which cannot reduce the proportion of drug-resistant epilepsy. Heat shock proteins (HSPs) are a kind of chaperone proteins, which can stabilize the structure and function of proteins. A large number of studies have found that HSP70 plays a role in the expression of inflammatory factors, inhibition of cell apoptosis, inhibition of protein aggregation, tumor, immunity and other aspects, and is closely related to the pathogenesis of nervous system diseases. This article summarized the research progress of HSP70 in epilepsy, in order to provide theoretical basis for the use of HSP70 related preparations in the treatment of epilepsy.