Toll样受体在幽门螺杆菌感染胃癌中的研究进展
Research Advance of Toll-Like Receptors in Gastric Cancer Infected by Helicobacter pylori
DOI: 10.12677/ACM.2022.123274, PDF,    科研立项经费支持
作者: 张 荣, 张 杰, 李志敏, 王 黎*：大理大学临床医学院，云南 大理
关键词: Toll样受体；幽门螺杆菌；胃癌；Toll-Like Receptors； Helicobacter pylori； Gastric Cancer
摘要: 幽门螺杆菌与胃癌密切相关，Toll样受体作为机体抗幽门螺杆菌感染免疫的第一道防线，能够通过激活PAMP、DAMP来促进炎症的发生发展过程。基于对这些受体信号通路的识别和激活，炎症过程和基因多态性可能参与调节发生胃癌的风险，Toll样受体基因多态性可能在幽门螺杆菌感染易感性中起一定作用，并可能影响其结局。本文就目前Toll样受体与幽门螺杆菌感染的关系以及介导胃癌作用的机制相关研究进行总结，为胃癌的发生发展机制研究以及胃癌治疗靶点的选择提供方向。
Abstract: Helicobacter pylori is closely related to gastric cancer. Toll-like receptor, as the first line of defense against Helicobacter pylori infection, can promote the occurrence and development of inflammation by activating PAMP and DAMP. Based on the recognition and activation of these receptor signaling pathways, inflammatory process and gene polymorphism may be involved in regulating the risk of gastric cancer, and Toll-like receptor gene polymorphism may play a role in the susceptibility to Helicobacter pylori infection and may affect its outcome. This article summarizes the current research on the relationship between Toll-like receptors and Helicobacter pylori infection and the mechanism of mediating gastric cancer, in order to provide a direction for the study of the mechanism of occurrence and development of gastric cancer and the selection of therapeutic targets for gastric cancer.
文章引用：张荣, 张杰, 李志敏, 王黎. Toll样受体在幽门螺杆菌感染胃癌中的研究进展[J]. 临床医学进展, 2022, 12(3): 1903-1909. https://doi.org/10.12677/ACM.2022.123274

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