外泌体在炎症性疾病中的研究进展
Advances in the Study of Exosomes in Inflammatory Diseases
摘要: 外泌体是从胞内分泌到胞外的直径为30~150 nm的囊泡。此外，外泌体也可在血液、尿液、唾液、胸膜液、乳汁等体液中发现。同时，外泌体也参与细胞间分子传递，在细胞间信息传递中发挥重要作用。近年来，炎症性疾病的外泌体研究取得了重大突破，大量研究发现，外泌体与各种炎症性疾病的发生发展密切相关，因此外泌体有望成为炎症性疾病治疗的一个新的诊断方向和治疗靶点，本文综述了目前的研究进展，重点介绍了外泌体在各类炎症性疾病中的作用机制及其对炎症性疾病的影响，以期为后续研究提供相关思路和理论指导。
Abstract: Exosomes are vesicles 30~150 nm in diameter that are secreted from the intracellular to the extracellular. In addition, exosomes can also be found in body fluids such as blood, urine, saliva, pleural fluid and breast milk. Exosomes are also involved in intercellular molecular transmission and play an important role in intercellular messaging. In recent years, significant breakthroughs have been made in the study of exosomes in inflammatory diseases, and a large number of studies have found that exosomes are closely related to the development of various inflammatory diseases, thus exosomes are expected to become a new diagnostic direction and therapeutic target for the treatment of inflammatory diseases. This article reviews the current research progress, focuses on the mechanisms of exosomes in various inflammatory diseases and their effects on inflammatory diseases, with a view to providing relevant ideas and theoretical guidance for subsequent research.
文章引用：汤绍波, 李卓然, 李志敏, 徐佳琪, 王黎. 外泌体在炎症性疾病中的研究进展[J]. 临床医学进展, 2022, 12(3): 1910-1915. https://doi.org/10.12677/ACM.2022.123275

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