摘要: 目的：评估维生素D水平在IPAF患者中的水平。方法：回顾性分析比较2020年9月至2021年9月期间于青岛大学附属医院呼吸与危重症医学科初诊IPAF的患者共63例。记录入组患者的基本资料、实验室检查数据等，用1,25(OH)2D3的水平评估维生素D水平。应用SPSS25.0进行数据分析。结果：血清25-OH-D水平分别和D二聚体、IL-6、CD4细胞绝对计数、二氧化碳分压、空腹血糖、血钙水平之间无显著相关性(P > 0.05)。与BMI (r = 0.265, P < 0.05)、氧饱和度(r = 0.327, P < 0.01)、FEV1/FVC (r = −0.373, P < 0.01)、TLC (r = 0.357, P < 0.01)、肺动脉压(r = −0.367, P < 0.01)水平之间为弱相关性。与血沉(r = −0.587, P < 0.01)、氧分压(r = 0.580, P < 0.01)、六分钟步行距离(r = 0.507, P < 0.01)、FEV1 (r = 0.537, P < 0.01)、FVC (r = 0.580, P < 0.01)、mMRC评分(r = 0.588, P < 0.01)之间为中等程度相关性，与DLCO (r = 0.686, P < 0.01)为强相关性。结论：IPAF患者血清维生素D水平越低，患者六分钟步行距离、DLCO水平越低，提示血清维生素D水平与IPAF患者的肺功能损害、疾病严重程度相关。
Abstract:
Objective: To assess the level of vitamin D levels in patients with IPAF. Methods: A total of 63 newly diagnosed IPAF patients in the Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Qingdao University between September 2020 and September 2021 were retrospectively analyzed and compared. The basic data and laboratory data of the patients were recorded, assessed with the level of 1,25(OH)2D3. SPSS25.0 was applied for data analysis. Results: There was no significant correlation between serum 25-OH-D levels and D-dimer, IL-6, absolute CD4 cell count, partial pressure of carbon dioxide, lactate, fasting blood glucose, serum calcium, and creatinine levels, respectively (P > 0.05). There was a weak correlation with BMI (r = 0.265, P < 0.05), oxygen saturation (r = 0.327, P < 0.01), FEV1/FVC (r = −0.373, P < 0.01), TLC (r = 0.357, P < 0.01), and pulmonary arterial pressure (r = −0.367, P < 0.01). ESR (r = −0.587, P < 0.01), Oxygen partial pressure (r = 0.580, P < 0.01), 6-minute walking distance (r = 0.507, P < 0.01), FEV1 (r = 0.537, P < 0.01), FVC (r = 0.580, P < 0.01), mMRC score (r = 0.588, P < 0.01) were moderately correlated, and strongly with DLCO (r = 0.686, P < 0.01). Conclusion: The lower the serum vitamin D level, the lower the six-minute walk distance and DLCO level in patients with IPAF, suggesting that the serum vitamin D level is related to the pulmonary function impairment and disease severity in patients with IPAF.