RNA结合蛋白在肝癌中的研究进展
RNA Binding Protein in Hepatocellular Carcinoma: Recent Research Progress
DOI: 10.12677/ACM.2022.123302, PDF,   
作者: 谢国伟, 闫 军*, 樊海宁：青海大学研究生院，青海 西宁
关键词: 肝癌；RNA结合蛋白；RBPs；分子机制；HCC； RNA Binding Protein； RBPs； Molecular Mechanism
摘要: 肝癌是人类常见的恶性肿瘤，其发病率高，预后差，严重影响着人类的健康。RNA结合蛋白(RBPs)是一类与RNA结合的蛋白质，在基因的转录后调控中发挥了重要作用，通过多种机制介导肿瘤细胞的增殖、转移、侵袭和凋亡，在肝癌的发生发展中发挥了重要作用。多种RBPs在肝癌中异常表达，并与肿瘤的诊断、预后显著相关，有望成为早期肝癌诊断的分子标志物。本文主要就近些年RBPs在肝癌中的研究情况进行综述。
Abstract: Hepatocellular carcinoma (HCC), with a high incidence rate and poor prognosis, is a common malignant tumor in human beings, which seriously affects human health. RNA binding protein is a kind of protein binding to RNA. It plays an important role in the post transcriptional regulation of genes. It plays an important role in the occurrence and development of hepatocellular carcinoma through multiple mechanisms mediating the proliferation, metastasis, invasion and apoptosis of tumor cells. A variety of RBPs are abnormally expressed in hepatocellular carcinoma and are significantly related to the diagnosis and prognosis of hepatocellular carcinoma. It is expected to become a molecular marker for the diagnosis of early hepatocellular carcinoma. This paper addresses the recent research progress of RNA binding protein in HCC.
文章引用：谢国伟, 闫军, 樊海宁. RNA结合蛋白在肝癌中的研究进展[J]. 临床医学进展, 2022, 12(3): 2103-2109. https://doi.org/10.12677/ACM.2022.123302

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