3.0TMR扩散加权成像在早期强直性脊柱炎活动性骶髂关节炎疗效评估中的应用价值研究

Application Value of 3.0TMR Diffusion Weighted Imaging in the Evaluation of Curative Effect of Early Ankylosing Spondylitis and Active Sacroiliac Arthritis

摘要: 目的：探讨3.0TMR扩散加权成像(DWI)在早期强直性脊柱炎(AS)活动性骶髂关节炎疗效评估中的应用价值。方法：收集56例行英夫利西单抗治疗的早期AS患者，治疗前、后分别行骶髂关节DWI及常规MRI检查，测量感兴趣区(ROI)的ADC值、采用独立样本配对t检验比较治疗前后的Bath强直性脊柱炎疾病活动度指数(BASDAI)评分、CRP、ADC值的差异。结果：治疗前与治疗后的BASDAI评分、CRP、ADC值分别为(6.85 ± 1.57)、(44.57 ± 4.58) mg/L、(1.23 ± 0.21) × 10⁻³ mm²/s、和(3.76 ± 1.48)、(23.31 ± 3.85) mg/L、(0.85 ± 0.22) × 10⁻³ mm²/s。治疗后的BASDAI评分、CRP、ADC值均低于治疗前，差异均有统计学意义(P值均<0.05)。结论：DWI功能图像及定量参数能有效评估早期AS骶髂关节炎患者的治疗效果。

Abstract: Objective: The purpose of this study to investigate the value of 3.0TMR diffusion weighted imaging (DWI) in early ankylosing spondylitis (AS) of curative effect of active sacroiliac arthritis. Methods: A total of 56 patients with early AS treated with infliximab were collected. Sacroiliac joint DWI and routine MRI were performed before and after treatment. The ADC value of region of interest (ROI) was measured, and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), CRP and ADC values before and after treatment were compared by independent sample paired t-test. Results: The BASDAI score, CRP and ADC values before and after treatment were (6.85 ± 1.57), (44.57 ± 4.58) mg/L, (1.23 ± 0.21) × 10⁻³ mm²/s and (3.76 ± 1.48), (23.31 ± 3.85) mg/L, (0.85 ± 0.22) × 10⁻³ mm²/s. The scores of BASDAI, CRP and ADC after treatment were lower than those before treatment, and the differences were statistically significant (P < 0.05). Conclusion: DWI functional images and quantitative parameters can effectively evaluate the therapeutic effect of patients with early AS sacroiliac arthritis.