S型半胱氨酸蛋白酶抑制剂对胃肠道肿瘤诊断的研究进展
Research Progress of S-Type Cystatins in the Diagnosis of Gastrointestinal Tumors
DOI: 10.12677/ACM.2022.123306, PDF,   
作者: 王多姿：西安医学院，陕西 西安；何 瑜, 史丽萍：陕西省人民医院消化内二科，陕西 西安
关键词: S型半胱氨酸蛋白酶抑制剂；胃癌；结直肠癌；S-Type Cystatins； Gastric Cancer； Colorectal Cancer
摘要: S型半胱氨酸蛋白酶抑制剂(S-type Cystatins)是半胱氨酸蛋白酶抑制剂超家族中家族2的成员，包括半胱氨酸蛋白酶抑制剂SN、SA以及S，在胃肠道恶性肿瘤的生长、侵袭转移等病理过程中发挥重要作用，并且S-type Cystatins在肿瘤组织中的表达水平与肿瘤的生长、侵袭转移程度及预后相关，有望成为新型的胃肠道肿瘤诊断分子标志物。本文就半胱氨酸蛋白酶抑制剂的分类、在肿瘤发生发展中的作用以及S型半胱氨酸蛋白酶抑制剂在胃肠道肿瘤诊断中的价值作一综述。
Abstract: S-type Cystatin is a member of family 2 in the Cystatins Superfamily, including SN, SA and S, which play an important role in the growth, invasion and metastasis of gastrointestinal tumors. The expression level of S-type Cystatin in tumor tissue is related to the growth, invasion, metastasis and prognosis of tumor, which is expected to become a new molecular marker for the diagnosis of gastrointestinal tumors. This article reviews the classification, structure, role of cystatins in tumor development and the value of S-type Cystatins in diagnosis of gastrointestinal tumors.
文章引用：王多姿, 何瑜, 史丽萍. S型半胱氨酸蛋白酶抑制剂对胃肠道肿瘤诊断的研究进展[J]. 临床医学进展, 2022, 12(3): 2131-2136. https://doi.org/10.12677/ACM.2022.123306

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