血脂水平与甲状腺癌的相关性研究及进展
Research and Progress on the Correlation between Serum Lipid Level and Thyroid Cancer
DOI: 10.12677/ACM.2022.123330, PDF,   
作者: 郝 娅, 张生军:延安大学附属医院普通外科,陕西 延安
关键词: 甲状腺癌甘油三酯胆固醇载脂蛋白A1Thyroid Cancer Triglyceride Cholesterol Apolipoprotein A1
摘要: 甲状腺癌是常见的头颈部肿瘤。在过去的五十年里,甲状腺癌的发病率翻了一番,这不能单独用已确定的甲状腺癌危险因素来解释,例如甲状腺癌家族史、电离辐射暴露和以前的甲状腺疾病。肥胖是目前公认的代谢综合征的一部分,代谢综合征还包括高血压、血脂异常和葡萄糖耐受不良。除BMI和甲状腺癌风险外,关于代谢因素的数据很少。肥胖与脂质代谢紊乱有关,血脂与甲状腺癌的关系尚不清楚。本文主要针对血脂水平与甲状腺癌的相关性研究及进展进行综述。
Abstract: Thyroid cancer is a common head and neck tumor. Over the past 50 years, the incidence of thyroid cancer doubled. It cannot separate with established thyroid cancer risk factors alone to explain, such as family history of thyroid cancer, ionizing radiation exposure, and thyroid disease. Obesity is now recognized as part of the metabolic syndrome. Metabolic syndrome includes hypertension, dyslipidemia and glucose intolerance. There is little data on metabolic factors other than BMI and thyroid cancer risk. Obesity is associated with lipid metabolism disorder, and the relationship between lipid and thyroid cancer is not clear. This article mainly reviews the research and progress of the correlation between blood lipid level and thyroid cancer.
文章引用:郝娅, 张生军. 血脂水平与甲状腺癌的相关性研究及进展[J]. 临床医学进展, 2022, 12(3): 2298-2302. https://doi.org/10.12677/ACM.2022.123330

参考文献

[1] Kitahara, C.M. and Sosa, J.A. (2016) The Changing Incidence of Thyroid Cancer. Nature Reviews Endocrinology, 12, 646-653. [Google Scholar] [CrossRef] [PubMed]
[2] Kilfoy, B.A., et al. (2009) International Patterns and Trends in Thyroid Cancer Incidence, 1973-2002. Cancer Causes & Control, 20, 525-531. [Google Scholar] [CrossRef] [PubMed]
[3] 李哲轩, 张阳, 周彤, 等. 2020全球癌症统计报告解读[J]. 肿瘤综合治疗电子杂志, 2021, 7(2): 1-13.
[4] 李宾, 姜晓峰. 代谢综合征的研究进展[J]. 国际检验医学杂志, 2018, 39(24): 2996-3001.
[5] Carioca, A.A.F., Steluti, J., de Carvalho, A.M., et al. (2021) Plasma Metabolomics Are Associated with Metabolic Syndrome: A Targeted Approach. Nutrition, 83, Article ID: 111082.
[6] 中华人民共和国国家卫生健康委员会. 甲状腺癌诊疗规范(2018年版) [J]. 中华普通外科学文献(电子版), 2019, 13(1): 1-15.
[7] 佚名. 中国成人血脂异常防治指南(2016年修订版) [J]. 中华心血管病杂志, 2016.
[8] White, C.P. (1909) On the Occurrence of Crystals in Tumors. The Journal of Pathology and Bacteriology, 13, 3-10. [Google Scholar] [CrossRef
[9] Tulinius, H., Sigfússon, N., Sigvaldason, H., et al. (1997) Risk Factors for Malignant Diseases: A Cohort Study on a Population of 22,946 Icelanders. Cancer Epidemiology Biomarkers & Prevention, 6, 863-873.
[10] Ulmer, H., Borena, W., Rapp, K., et al. (2009) Serum Triglyceride Concentrations and Cancer Risk in a Large Cohort Study in Austria. British Journal of Cancer, 101, 1202-1206. [Google Scholar] [CrossRef] [PubMed]
[11] Radišauskas, R., Kuzmickienė, I., Milinavičienė, E., et al. (2016) Hypertension, Serum Lipids and Cancer Risk: A Review of Epidemiological Evidence. Medicina, 52, 89-98. [Google Scholar] [CrossRef] [PubMed]
[12] 张美娜, 万雪婷. 南昌市第三医院健康体检人群甲状腺结节与血脂水平, 胰岛素抵抗的相关性分析[J]. 江西医药, 2021, 56(2): 4.
[13] Zhang, J., Song, Y., Shi, Q., et al. (2021) Research Progress on FASN and MGLL in the Regulation of Abnormal Lipid Metabolism and the Relationship between Tumor Invasion and Metastasis. Frontiers of Medicine, 15, 649-656. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, C., Zhou, X., Pan, Y., et al. (2021) Pyruvate Carboxylase Promotes Thyroid Cancer Aggressiveness through Fatty Acid Synthesis. BMC Cancer, 21, Article No. 722. [Google Scholar] [CrossRef] [PubMed]
[15] Pedersen, K.M., Olak, Y., Bojesen, S.E., et al. (2020) Low High-Density Lipoprotein and Increased Risk of Several Cancers: 2 Population-Based Cohort Studies Including 116,728 Individuals. Journal of Hematology & Oncology, 13, Article No. 129. [Google Scholar] [CrossRef] [PubMed]
[16] Mondul, A.M., Weinstein, S.J., Virtamo, J. and Albanes, D. (2011) Serum Total and HDL Cholesterol and Risk of Prostate Cancer. Cancer Causes & Control, 22, Article No. 1545. [Google Scholar] [CrossRef] [PubMed]
[17] Oh, H.Y., Lee, E.J., Yoon, S., Chung, B.H., Cho, K.S. and Hong, S.J. (2007) Cholesterol Level of Lipid Raft Microdomains Regulates Apoptotic Cell Death in Prostate Cancer Cells through EGFR-Mediated Akt and ERK Signal Transduction. The Prostate, 67, 1061-1069. [Google Scholar] [CrossRef] [PubMed]
[18] Loosen, S.H., Kostev, K., Luedde, M., et al. (2021) Low Blood Levels of High-Density Lipoprotein (HDL) Cholesterol Are Positively Associated with Cancer. Journal of Cancer Research and Clinical Oncology, 4-11. [Google Scholar] [CrossRef] [PubMed]
[19] Revilla, G., Pons, M., Baila-Rueda, L., et al. (2019) Cholesterol and 27-Hydroxycholesterol Promote Thyroid Carcinoma Aggressiveness. Scientific Reports, 9, Article No. 10260. [Google Scholar] [CrossRef] [PubMed]
[20] Gebhard, C., Maafi, F., Stähli, B.E., et al. (2018) Apolipoprotein A-I Proteolysis in Aortic Valve Stenosis: Role of Cathepsin S. Basic Research in Cardiology, 113, Article No. 30. [Google Scholar] [CrossRef] [PubMed]
[21] Yao, X.L., Gordan, E.M., Figueroa, D.M., et al. (2016) Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease. American Journal of Respiratory Cell and Molecular Biology, 55, 159-169. [Google Scholar] [CrossRef
[22] 黄坤寨, 肖方森, 张福星, 等. 载脂蛋白A1通过Wnt/β-catenin信号通路调控EMT在甲状腺癌转移中的作用[J]. 华中科技大学学报(医学版), 2019, 48(1): 9-14.
[23] Ma, M., Wang, M., Zhang, Z., et al. (2021) Apolipoprotein A1 Is Negatively Associated with Male Papillary Thyroid Cancer Patients: A Cross-Sectional Study of Single Academic Center in China. BMC Endocrine Disorders, 21, Article No. 69. [Google Scholar] [CrossRef] [PubMed]
[24] Robbins, R.J. (2003) Statins Sentence Thyroid Cancer Cells to Death Rho. Journal of Clinical Endocrinology & Metabolism, 88, 3019-3020.
[25] Mario, V., Di, M.T., Guido, R., et al. (1999) Prenyltransferase Inhibitors Induce Apoptosis in Proliferating Thyroid Cells through a p53-Independent CrmA-Sensitive, and Caspase-3-Like Protease-Dependent Mechanism. Endocrinology, 140, 698-704. [Google Scholar] [CrossRef] [PubMed]
[26] Smith, P.F., Grossman, S.J., Gerson, R.J., et al. (1991) Studies on the Mechanism of Simvastatin-Induced Thyroid Hypertrophy and Follicular Cell Adenoma in the Rat. Toxicologic Pathology, 19, 197-205. [Google Scholar] [CrossRef] [PubMed]
[27] Mascitelli, L. and Goldstein, M.R. (2015) Statin Immunomodulation and Thyroid Cancer. Clinical Endocrinology, 82, 620. [Google Scholar] [CrossRef] [PubMed]
[28] Trivedi, L.U., Mbuntum, L.F., Halm, E.A., et al. (2021) Is Statin Use Associated with Risk of Thyroid Diseases? Results of a Retrospective Cohort Study. Annals of Pharmacotherapy, 55, 1110-1119. [Google Scholar] [CrossRef] [PubMed]
[29] Kushchayeva, Y., Jensen, K., Burman, K.D., et al. (2014) Repositioning Therapy for Thyroid Cancer: New Insights on Established Medications. Endocrine-Related Cancer, 21, R183-R194. [Google Scholar] [CrossRef