中枢神经系统脱髓鞘疾病与痫性发作
Demyelinating Diseases of the Central Nervous System and Seizures
DOI: 10.12677/ACM.2022.123335, PDF,   
作者: 周雪莲, 李秀娟*:重庆医科大学附属儿童医院神经内科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿科学重庆市重点实验室,重庆
关键词: 中枢神经系统脱髓鞘疾病痫性发作少突胶质细胞糖蛋白IgG抗体相关疾病Demyelinating Diseases of the Central Nervous System Seizures Anti-Myelin Oligodendrocyte Glycoprotein-IgG Associated Disorders
摘要: 中枢神经系统脱髓鞘疾病是一种以神经功能障碍为主要表现的自身免疫性疾病,常见病种包括多发性硬化、视神经脊髓炎谱系疾病、少突胶质细胞糖蛋白IgG抗体相关疾病。这类疾病以视神经炎、脊髓炎、共济失调等为主要临床表现,部分有痫性发作。近年来,越来越多的研究表明,中枢神经脱髓鞘疾病与痫性发作有关,但其痫性发作的机制尚不明确。本文旨在对常见中枢神经脱髓鞘疾病与相关痫性发作进行综述。
Abstract: Demyelinating diseases of the central nervous system are autoimmune diseases with neurological dysfunction as the main manifestation. Common diseases include multiple sclerosis, neuromyelitis optica spectrum disorders, anti-myelin oligodendrocyte glycoprotein-IgG associated disorders. The prominent clinical symptoms include optic neuritis, myelitis and ataxia, and seizures. In recent years, more and more studies have shown that demyelinating diseases of the central nervous system are related to seizures, but the mechanism is not clear. This paper aims to review demyelinating diseases of the central nervous system and related seizures.
文章引用:周雪莲, 李秀娟. 中枢神经系统脱髓鞘疾病与痫性发作[J]. 临床医学进展, 2022, 12(3): 2329-2333. https://doi.org/10.12677/ACM.2022.123335

参考文献

[1] Hoftberger, R. and Lassmann, H. (2017) Inflammatory Demyelinating Diseases of the Central Nervous System. In: Handbook of Clinical Neurology, Vol. 145, Elsevier, Amsterdam, 263-283. [Google Scholar] [CrossRef
[2] Ajmi, H., Jammeli, N., Hassayoun, S., et al. (2021) Acute Disseminated Encephalomyelitis: A Retrospective Study of 20 Children in a Pediatrics Department in Tunisia. Archives de Pédiatrie, 28, 638-646. [Google Scholar] [CrossRef] [PubMed]
[3] Yao, Y., Xu, Y., Ren, H., et al. (2019) Acute Epileptic Seizures in Myelin Oligodendrocyte Glycoprotein Encephalomyelitis and Neuromyelitis Optica Spectrum Disorder: A Comparative Cohort Study. Multiple Sclerosis and Related Disorders, 27, 281-288. [Google Scholar] [CrossRef] [PubMed]
[4] Fujimori, J., Takai, Y., Nakashima, I., et al. (2017) Bilateral Frontal Cortex Encephalitis and Paraparesis in a Patient with Anti-MOG Antibodies. Journal of Neurology, Neurosurgery & Psychiatry, 88, 534-536. [Google Scholar] [CrossRef] [PubMed]
[5] Wegener-Panzer, A., Cleaveland, R., Wendel, E., et al. (2020) Clinical and Imaging Features of Children with Autoimmune Encephalitis and MOG Antibodies. Neurology—Neuroimmunology Neuroinflammation, 7, e731. [Google Scholar] [CrossRef
[6] Baumann, M., Sahin, K., Lechner, C., et al. (2015) Clinical and Neuroradiological Differences of Paediatric Acute Disseminating Encephalomyelitis with and without Antibodies to the Myelin Oligodendrocyte Glycoprotein. Journal of Neurology, Neurosurgery & Psychiatry, 86, 265-272. [Google Scholar] [CrossRef] [PubMed]
[7] Ramanathan, S., Mohammad, S., Tantsis, E., et al. (2018) Clinical Course, Therapeutic Responses and Outcomes in Relapsing MOG Antibody-Associated Demyelination. Journal of Neurology, Neurosurgery & Psychiatry, 89, 127-137. [Google Scholar] [CrossRef] [PubMed]
[8] Ding, J., Li, X. and Tian, Z. (2021) Clinical Features of Coexisting Anti-NMDAR and MOG Antibody-Associated Encephalitis: A Systematic Review and Meta-Analysis. Frontiers in Neurology, 12, Article ID: 711376. [Google Scholar] [CrossRef] [PubMed]
[9] Fan, S., Xu, Y., Ren, H., et al. (2018) Comparison of Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Disease and AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder (NMOSD) When They Co-Exist with Anti-NMDA (N-methyl-D-aspartate) Receptor Encephalitis. Multiple Sclerosis and Related Disorders, 20, 144-152. [Google Scholar] [CrossRef] [PubMed]
[10] Calabrese, M., Grossi, P., Favaretto, A., et al. (2011) Cortical Pathology in Multiple Sclerosis Patients with Epilepsy: A 3 Year Longitudinal Study. Journal of Neurology, Neurosurgery & Psychiatry, 83, 49-54. [Google Scholar] [CrossRef] [PubMed]
[11] Hacohen, Y., Wong, Y.Y., Lechner, C., et al. (2018) Disease Course and Treatment Responses in Children with Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. JAMA Neurology, 75, 478. [Google Scholar] [CrossRef] [PubMed]
[12] Rossor, T., Benetou, C., Wright, S., et al. (2020) Early Predictors of Epilepsy and Subsequent Relapse in Children with Acute Disseminated Encephalomyelitis. Multiple Sclerosis Journal, 26, 333-342. [Google Scholar] [CrossRef] [PubMed]
[13] Ogawa, R., Nakashima, I., Takahashi, T., et al. (2017) MOG Antibody-Positive, Benign, Unilateral, Cerebral Cortical Encephalitis with Epilepsy. Neurology: Neuroimmunology & Neuroinflammation, 4, e322. [Google Scholar] [CrossRef
[14] Shu, H., Ding, M., Shang, P., et al. (2022) Myelin Oligodendrocyte Glycoprotein Antibody Associated Cerebral Cortical Encephalitis: Case Reports and Review of Literature. Frontiers in Human Neuroscience, 15, Article ID: 782490. [Google Scholar] [CrossRef] [PubMed]
[15] Mahamud, Z., Burman, J. and Zelano, J. (2018) Risk of Epilepsy after a Single Seizure in Multiple Sclerosis. European Journal of Neurology, 25, 854-860. [Google Scholar] [CrossRef] [PubMed]
[16] Zhong, X., Zhou, Y., Chang, Y., et al. (2019) Seizure and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis in a Retrospective Cohort of Chinese Patients. Frontiers in Neurology, 10, Article No. 415. [Google Scholar] [CrossRef] [PubMed]
[17] Etemadifar, M., Sabeti, F., Khorvash, R., et al. (2021) Seizure Incidence among Neuromyelitis Optica Spectrum Disorder Patients. Revue Neurologique, 177, 655-659. [Google Scholar] [CrossRef] [PubMed]
[18] Hamid, S.H.M., Whittam, D., Saviour, M., et al. (2018) Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease. JAMA Neurology, 75, 65. [Google Scholar] [CrossRef] [PubMed]
[19] Langenbruch, L., Krämer, J., Güler, S., et al. (2019) Seizures and Epilepsy in Multiple Sclerosis: Epidemiology and Prognosis in a Large Tertiary Referral Center. Journal of Neurology, 266, 1789-1795. [Google Scholar] [CrossRef] [PubMed]
[20] Thomas, F., Matteo, G., Silvia, S., et al. (2020) Seizures and Myelin Oligodendrocyte Glycoprotein (MOG) Antibodies: Two Paradigmatic Cases and a Review of the Literature. Multiple Sclerosis and Related Disorders, 41, Article ID: 102011. [Google Scholar] [CrossRef] [PubMed]
[21] Tao, R., Qin, C., Chen, M., et al. (2020) Unilateral Cerebral Cortical Encephalitis with Epilepsy: A Possible Special Phenotype of MOG Antibody-Associated Disorders. International Journal of Neuroscience, 130, 1161-1165. [Google Scholar] [CrossRef] [PubMed]
[22] 孙红, 谭建敏, 刘静临, 等. 儿童髓鞘少突胶质细胞糖蛋白抗体相关脱髓鞘病57例临床特征及预后分析[J]. 临床儿科杂志, 2020, 38(11): 824-830.
[23] Ramanathan, S., O’Grady, G.L., Malone, S., et al. (2018) Isolated Seizures during the First Episode of Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Demyelination in Children. Developmental Medicine & Child Neurology, 61, 610-614. [Google Scholar] [CrossRef] [PubMed]
[24] Taraschenko, O. and Zabad, R. (2019) Overlapping Demyelinating Syndrome and Anti-N-methyl-d-aspartate Receptor Encephalitis with Seizures. Epilepsy & Behavior Reports, 12, Article ID: 100338. [Google Scholar] [CrossRef] [PubMed]
[25] Jarius, S., Paul, F., Aktas, O., et al. (2018) MOG Encephalomyelitis: International Recommendations on Diagnosis and Antibody Testing. Journal of Neuroinflammation, 15, 134. [Google Scholar] [CrossRef] [PubMed]
[26] Hacohen, Y., Absoud, M., Deiva, K., et al. (2015) Myelin Oligodendrocyte Glycoprotein Antibodies Are Associated with a Non-MS Course in Children. Neurology: Neuroimmunology & Neuroinflammation, 2, e81. [Google Scholar] [CrossRef
[27] de Mol, C.L., Wong, Y., van Pelt, E.D., et al. (2020) The Clinical Spectrum and Incidence of Anti-MOG-Associated Acquired Demyelinating Syndromes in Children and Adults. Multiple Sclerosis Journal, 26, 806-814. [Google Scholar] [CrossRef] [PubMed]
[28] Mclaughlin, K.A., Chitnis, T., Newcombe, J., et al. (2009) Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis. Journal of Immunology, 183, 4067-4076. [Google Scholar] [CrossRef] [PubMed]
[29] Narayan, R.N., Wang, C., Sguigna, P., et al. (2019) A Typical Anti-MOG Syndrome with Aseptic Meningoencephalitis and Pseudotumor Cerebri-Like Presentations. Multiple Sclerosis and Related Disorders, 27, 30-33. [Google Scholar] [CrossRef] [PubMed]
[30] Jurynczyk, M., Messina, S., Woodhall, M.R., et al. (2017) Clinical Presentation and Prognosis in MOG-Antibody Disease: A UK Study. Brain, 140, 3128-3138. [Google Scholar] [CrossRef] [PubMed]
[31] Whittam, D.H., Karthikeayan, V., Gibbons, E., et al. (2020) Treatment of MOG Antibody Associated Disorders: Results of an International Survey. Journal of Neurology, 267, 3565-3577. [Google Scholar] [CrossRef] [PubMed]
[32] 杨赛, 廖红梅, 吴丽文, 等. 儿童MOG抗体病复发危险因素分析[J]. 临床儿科杂志, 2021, 39(12): 916-922.
[33] Reindl, M. and Waters, P. (2019) Myelin Oligodendrocyte Glycoprotein Antibodies in Neurological Disease. Nature Reviews. Neurology, 15, 89-102. [Google Scholar] [CrossRef] [PubMed]
[34] Narayan, R., Simpson, A., Fritsche, K., et al. (2018) MOG Antibody Disease: A Review of MOG Antibody Seropositive Neuromyelitis Optica Spectrum Disorder. Multiple Sclerosis and Related Disorders, 25, 66-72. [Google Scholar] [CrossRef] [PubMed]
[35] Thompson, A.J., Baranzini, S.E., Geurts, J., et al. (2018) Multiple Sclerosis. The Lancet, 391, 1622-1636. [Google Scholar] [CrossRef
[36] Fujihara, K., Misu, T., Nakashima, I., et al. (2012) Neuromyelitis Optica Should Be Classified as an Astrocytopathic Disease Rather than a Demyelinating Disease. Clinical & Experimental Neuroimmunology, 3, 58-73. [Google Scholar] [CrossRef