原发性先天性青光眼研究进展
Research Progress of Primary Congenital Glaucoma (PCG)
DOI: 10.12677/HJO.2022.111015, PDF,   
作者: 于 琼：安徽省蚌埠市第二人民医院眼科，安徽 蚌埠
关键词: 原发性先天性青光眼；发病原因；治疗；Primary Congenital Glaucoma； Causes； Treatment
摘要: 青光眼，作为一种致盲性眼病，具有发病率高涉及地区广的特点。很大程度上剥夺了患者的视觉健康及质量。临床观察发现，大部分青光眼患者具有起病急、病情进展迅速的特点，发病者往往因为未及时有效的降低眼压，严重损伤了视神经且难以恢复，部分患者最终走向失明的结局。近年来，原发性先天性青光眼作为损害婴幼儿视力的第一大原因，越来越受到临床医师广泛关注，治疗方法也日趋成熟，及时有效地干预大大挽救了婴幼儿视力，提高了患儿生活质量。本文就原发性先天性青光眼的研究现状进展做一综述。
Abstract: Glaucoma, as a blinding eye disease, has the characteristics of high incidence and wide coverage. It deprives the patient of visual health and quality to a large extent. Clinical observation found that the majority of glaucoma patients have the characteristics of acute onset and rapid progress of the disease. The optic nerve is seriously damaged and difficult to recover due to the failure of timely and effective reduction of IOP, and some patients eventually go blind. In recent years, primary congenital glaucoma, as the first cause of visual impairment in infants, has attracted more and more attention from clinicians, and treatment methods are becoming increasingly mature. Timely and effective intervention has greatly saved infants’ visual acuity and improved their quality of life. This article reviews the research progress of primary congenital glaucoma.
文章引用：于琼. 原发性先天性青光眼研究进展[J]. 眼科学, 2022, 11(1): 93-98. https://doi.org/10.12677/HJO.2022.111015

参考文献

[1] Saltzmann, R.M., Reinecke, S., Lin, X., Cavanagh, H.D. and Whitson, J. (2012) Long-Term Outcomes of Apseudo 360 Degree Trabeculotomy ab externo Technique for Congenital Glaucoma at Children’s Medical Center. Clinical Ophthalmology, 6, 689-698
[Google Scholar] [CrossRef] 
[2] Kim, Y.J., Jeoung, J.W., Kim, M.K., Park, K.H., Yuy, S. and Oh, J.Y. (2018) Clinical Features and Outcome of Corneal Opacity Associated with Congenital Glaucoma. BMC Ophthalmology, 18, Article No. 190.
[Google Scholar] [CrossRef] [PubMed]
[3] Gencik, A., Gencikova, A. and Gerinec, A. (1980) Genetic-Heterogeneity of Congenital Glaucoma. Clinical Genetics, 17, 241-248.
[Google Scholar] [CrossRef] [PubMed]
[4] Suh, W. and Kee, C. (2012) A Clinical and Molecular Genetics Study of Primary Congenital Glaucoma in South Korea. British Journal of Ophthalmology, 96, Article No. 1372.
[Google Scholar] [CrossRef] [PubMed]
[5] Sarfarazi, M., Stoilov, I. and Schenkman, J.B. (2003) Genetics and Biochemistry of Primary Congenital Glaucoma. Ophthalmology Clinics of North America, 16, 543-554.
[Google Scholar] [CrossRef] 
[6] Anderson, D.R. (1981) The Development of the Trabecular Meshwork and Its Abnormality in Primary Infantile Glaucoma. Transactions of the American Ophthalmological Society, 79, 458-485.
[7] Tawara, A. and Inomata, H. (1981) Developmental Immaturity of the Trabecular Meshwork in Congenital Glaucoma. American Journal of Ophthalmology, 92, 508-525.
[Google Scholar] [CrossRef] [PubMed]
[8] 凌晨. P-A基因在原发性先天性青光眼中的作用研究[D]: [硕士学位论文]. 成都: 电子科技大学, 2020.
[9] 宋娜. 先天性青光眼患者CYP1B1及LTBP2基因突变筛查的研究[D]: [硕士学位论文]. 青岛: 青岛大学, 2018.
[10] Fernandes, N.D. and Badri, T. (2018) Herpes, Simplex, Congenital. StatPearls, Treasure Island. http://europepmc.org/article/MED/29939674
[11] 冯丽丽, 王晓蕾, 王朱健, 曹文俊, 陈雪莉. 先天性青光眼患儿房水及血清疱疹病毒抗体检测分析[J]. 中国眼耳鼻喉科杂志, 2018, 18(5): 325-328.
[12] Chang, L., Ong, E.L., Bunce, C., Brookes, J., Papadopoulos, M. and Khaw, P.T. (2013) A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital. Journal of Glaucoma, 22, 601-607.
[Google Scholar] [CrossRef] 
[13] Ho, C.L. and Walton, D.S. (2004) Primary Congenital Glaucoma: 2004 Update. Journal of Pediatric Ophthalmology & Strabismus, 41, 271-288.
[Google Scholar] [CrossRef] [PubMed]
[14] Larsson, L.I. and Alm, A. (1998) Aqueous Humor Flow in Human Eyes Treated with Dorzolamide and Different Doses of Acetazolamide. Archives of Ophthalmology, 116, 19-24.
[Google Scholar] [CrossRef] [PubMed]
[15] Wayman, L.L., Larsson, L.I., Maus, T.L. and Brubaker, R.F. (1998) Additive Effect of Dorzolamide on Aqueous Humor Flow in Patients Receiving Long-Term Treatment with Timolol. Archives of Ophthalmology, 116, 1438-1440.
[Google Scholar] [CrossRef] [PubMed]
[16] Toris, C.B., Gleason, M.L., Camras, C.B. and Yablonski, M.E. (1995) Effects of Brimonidine on Aqueous Humor Dynamics in Human Eyes. Archives of Ophthalmology, 113, 1514-1517.
[Google Scholar] [CrossRef] [PubMed]
[17] Carlsen, J.O., Zabriskie, N.A., Kwon, Y.H., Barbe, M.E. and Scott, W.E. (1999) Apparent Central Nervous System Depression in Infants after the Use of Topical Brimonidine. American Journal of Ophthalmology, 128, 255-256.
[Google Scholar] [CrossRef] 
[18] Uva, M.G., Avitabile, T., Reibaldi, M., Bucolo, C., Drago, F., Quaranta, L., et al. (2014) Long-Term Efficacy of Latanoprost in Primary Congenital Glaucoma. Eye, 28, 53-57.
[Google Scholar] [CrossRef] [PubMed]
[19] Traynor, K. (2012) FDA Approves Glaucoma Treatment. American Journal of Health-System Pharmacy, 69, 446.
[Google Scholar] [CrossRef] [PubMed]
[20] Hoffmann, E.M., Aghayeva, F., Schuster, A.K., Pfeiffer, N., Karsten, M., Schweiger, S., et al. (2021) Results of Childhood Glaucoma Surgery over a Long-Term Period. Acta Ophthalmologica, 100, e448-e454.
[Google Scholar] [CrossRef] [PubMed]
[21] Mandal, A.K., Gothwal, V.K., Bagga, H., Nutheti, R. and Mansoori, T. (2003) Outcome of Surgery on Infants Younger than 1 Month with Congenital Glaucoma. Ophthalmology, 110, 1909-1915.
[Google Scholar] [CrossRef] 
[22] Wagdy, F.M. (2020) Ab Externo 240-Degree Trabeculotomy versus Trabeculotomy-Trabeculectomy in Primary Congenital Glaucoma. International Ophthalmology, 40, 2699-2706.
[Google Scholar] [CrossRef] [PubMed]
[23] Elwchidy, A.S., Haggras, S.M., Bayoum, I.N., Abdelghafar, A.E. and Badawi, A.E. (2020) Five-Year Results of Viscotrabeculotomy versus Conventional Trabeculotomy in Primary Congenitalglaucoma: A Randomized Controlled Study. European Journal of Ophthalmology, 31, 786-795.
[Google Scholar] [CrossRef] [PubMed]
[24] Nakane, T., Kousuke, N., Sonoko, H., Yuko, K., Sato, H., Kubota, T., et al. (2013) Subtelomere Deletion with Congenital Glaucoma, Severe Mental Etardation, and Growth Impairment. Pediatrics International, 55, 376-381.
[Google Scholar] [CrossRef] 
[25] Mendes, M.H., Betinjane, A.J. and Quiroga, V.A. (2013) Correlations between Different Tonometries and Ocular Biometric Parameters in Patients with Primary Congenital Glaucoma. Arquivos Brasileiros De Oftalmologia, 76, 354-356.
[Google Scholar] [CrossRef] 
[26] Alharkan, D.H. and Khan, A.O. (2013) Markedly Asymmetric Buphthalmos but without Anisometropia in a Girl with Primary Congenital Glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus, 17, 533-534.
[Google Scholar] [CrossRef] [PubMed]
[27] 宋宴鹏, 毕华婷, 于海燕, 王铁柱. 可疑先天性青光眼胎儿一例[J].中华围产医学杂志, 2020, 23(8): 549-551.

为你推荐