手足口病CA6和CA10的流行病学及临床特征研究进展
Research Progress of Hand, Foot and Mouth Disease CA6 and CA10
DOI: 10.12677/ACM.2022.123348, PDF,   
作者: 张 力, 许红梅*:重庆医科大学附属儿童医院感染科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆
关键词: 手足口病柯萨奇病毒A6柯萨奇病毒A10流行病学预防措施Hand Foot and Mouth Disease Coxsackie Virus A6 Coxsackie Virus A10 Epidemiology Preventive Measure
摘要: 手足口病是一种严重威胁婴幼儿健康的急性传染病,主要表现为发热及手、足、口部的皮疹,肠道病毒71 (EV-A71)和柯萨奇病毒A16 (CV-A16)为最常见的致病原。近年来,由于CV-A6和CV-A10逐渐增多并成为了主要的病原体,标志着手足口病肠道病毒的病原谱正发生着改变。目前针对手足口病的预防和监测主要集中在EV-71和CV-A16,因此,进一步明确CV-A6和CV-A10的病原学特征、流行病学及临床特点对于该疾病的预防、治疗具有显著意义。
Abstract: Hand, foot and mouth disease (HFMD) is an acute infectious disease that seriously threatens the health of infants and young children. The main manifestations are fever and skin rash on hands, feet and mouth. Enterovirus 71 (EV-A71) and Coxsackie virus A16 (CV-A16) are the most common pathogenic factors. In recent years, cV-A6 and CV-A10 have gradually increased and become the main pathogens, indicating that the pathogenic spectrum of enterovirus of HFMD is changing. At present, the prevention and monitoring of HFMD mainly focus on EV-71 and CV-A16. Therefore, it is of significant significance to further clarify the etiological, epidemiological and clinical characteristics of CV-A6 and CV-A10 for the prevention and treatment of this disease.
文章引用:张力, 许红梅. 手足口病CA6和CA10的流行病学及临床特征研究进展[J]. 临床医学进展, 2022, 12(3): 2410-2416. https://doi.org/10.12677/ACM.2022.123348

参考文献

[1] Zhao, J., Jiang, F., Zhong, L., et al. (2016) Age Patterns and Transmission Characteristics of Hand, Foot and Mouth Disease in China. BMC Infectious Diseases, 16, Article No. 691. [Google Scholar] [CrossRef] [PubMed]
[2] Xie, Y.H., Tan, Y., et al. (2015) Important Roles of Public Playgrounds in the Transmission of Hand, Foot, and Mouth Disease. Epidemiology & Infection, 143, 1432-1441. [Google Scholar] [CrossRef
[3] Li, X.W., Ni, X., Qian, S.Y., et al. (2018) Chinese Guidelines for the Diagnosis and Treatment of Hand, Foot and Mouth Disease (2018 Edition). World Journal of Pediatrics, 14, 437-447. [Google Scholar] [CrossRef] [PubMed]
[4] Ooi, M.H., et al. (2010) Clinical Features, Diagnosis, and Management of Enterovirus 71. The Lancet Neurology, 9, 1097-1105. [Google Scholar] [CrossRef
[5] Chang, Y.K., Chen, K.H. and Chen, K.T. (2018) Hand, Foot and Mouth Disease and Herpangina Caused by Enterovirus A71 Infections: A Review of Enterovirus A71 Molecular Epidemiology, Pathogenesis, and Current Vaccine Development. Revista do Instituto de Medicina Tropical de São Paulo, 8, 60-70. [Google Scholar] [CrossRef] [PubMed]
[6] Mtvha, B., Tan, A., Tan, T., et al. (2019) Clinical and Aetiological Study of Hand, Foot and Mouth Disease in Southern Vietnam, 2013-2015: Inpatients and Outpatients. International Journal of Infectious Diseases, 80, 1-9. [Google Scholar] [CrossRef] [PubMed]
[7] Chan, L.G., Parashar, U.D., Lye, M.S., et al. (2000) Deaths of Children during an Outbreak of Hand, Foot, and Mouth Disease in Sarawak, Malaysia: Clinical and Pathological Characteristics of the Disease. Clinical Infectious Diseases, 31, 678-683. [Google Scholar] [CrossRef] [PubMed]
[8] Puenpa, J., Chieochansin, T., Linsuwanon, P., et al. (2013) Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Thailand, 2012. Emerging Infectious Diseases, 19, 641-643. [Google Scholar] [CrossRef] [PubMed]
[9] Fujimoto, T., Chikahira, M., Yoshida, S., et al. (2002) Outbreak of Central Nervous System Disease Associated with Hand, Foot, and Mouth Disease in Japan during the Summer of 2000: Detection and Molecular Epidemiology of Enterovirus 71. Microbiology and Immunology, 46, 621-627. [Google Scholar] [CrossRef] [PubMed]
[10] Ganorkar, N.N., Patil, P.R., Tikute, S.S., et al. (2017) Genetic Characterization of Enterovirus Strains Identified in Hand, Foot and Mouth Disease (HFMD, Emergence of B1c, C1 Subgenotypes, E2 Sublineage of CVA16, EV71 and CVA6 Strains in India. Infection, Genetics and Evolution, 54, 192-199. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, Y.Y., Zhu, Z., Yang, W., et al. (2010) An Emerging Recombinant Human Enterovirus 71 Responsible for the 2008 Outbreak of Hand Foot and Mouth Disease in Fuyang City of China. Virology Journal, 7, 94. [Google Scholar] [CrossRef
[12] Liu, S.L., Pan, H., Liu, P., et al. (2015) Comparative Epidemiology and Virology of Fatal and Nonfatal Cases of Hand, Foot and Mouth Disease in Mainland China from 2008 to 2014. Reviews in Medical Virology, 25, 115-128. [Google Scholar] [CrossRef] [PubMed]
[13] Zhang, J. (2019) Trend of Epidemics and Variation of Pathogens of Hand, Foot and Mouth Disease in China: A Dynamic Series Analysis, 2008-2017. Chinese Journal of Endemiology, 40, 147-154.
[14] Lu, Q.B., Zhang, X.A., Wo, Y., et al. (2012) Circulation of Coxsackievirus A10 and A6 in Hand-Foot-Mouth Disease in China, 2009-2011. PLoS ONE, 7, e52073. [Google Scholar] [CrossRef] [PubMed]
[15] 张萌, 陈祥鹏, 谢正德. 我国近十年手足口病病原谱及分子流行病学研究进展[J]. 中华实验和临床病毒学杂志, 2020, 34(6): 660-664.
[16] Blomqvist, S., Klemola, P., Kaijalainen, S., et al. (2010) Co-Circulation of Coxsackieviruses A6 and A10 in Hand, Foot and Mouth Disease Outbreak in Finland. Journal of Clinical Virology, 48, 49-54. [Google Scholar] [CrossRef] [PubMed]
[17] Osterback, R., Vuorinen, T., Linna, M., et al. (2009) Coxsackievirus A6 and Hand, Foot, and Mouth Disease, Finland. Emerging Infectious Diseases, 15, 1485-1488. [Google Scholar] [CrossRef] [PubMed]
[18] Javier, L.D., et al. (2011) Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses. Pediatric Dermatology, 28, 1-5. [Google Scholar] [CrossRef] [PubMed]
[19] Wu, Y., et al. (2010) The Largest Outbreak of Hand; Foot and Mouth Disease in Singapore in 2008: The Role of Enterovirus 71 and Coxsackievirus A Strains. International Journal of Infectious Diseases, 14, e1076-e1081. [Google Scholar] [CrossRef] [PubMed]
[20] Tsuguto, F., Setsuko, I., Miki, E., et al. (2012) Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Japan, 2011. Emerging Infectious Diseases, 18, 337. [Google Scholar] [CrossRef] [PubMed]
[21] Mirand, A., Henquell, C., Archimbaud, C., et al. (2012) Outbreak of Hand, Foot and Mouth Disease/Herpangina Associated with Coxsackievirus A6 and A10 Infections in 2010, France: A Large Citywide, Prospective Observational Study. Clinical Microbiology and Infection, 18, E110-E118. [Google Scholar] [CrossRef] [PubMed]
[22] Gopalkrishna, V., Patil, P.R., Patil, G.P., et al. (2012) Circulation of Multiple Enterovirus Serotypes Causing Hand, Foot and Mouth Disease in India. Journal of Medical Microbiology, 61, 420-425. [Google Scholar] [CrossRef] [PubMed]
[23] Lo, S.H., Huang, Y.C., Huang, C.G., et al. (2011) Clinical and Epidemiologic Features of Coxsackievirus A6 Infection in Children in Northern Taiwan between 2004 and 2009. Journal of Microbiology, Immunology, and Infection, 44, 252-257. [Google Scholar] [CrossRef] [PubMed]
[24] Wei, S.H., Huang, Y.P., Liu, M.C., et al. (2010) An Outbreak of Coxsackievirus A6 Hand, Foot, and Mouth Disease Associated with Onychomadesis in Taiwan. BMC Infectious Diseases, 11, Article No. 346. [Google Scholar] [CrossRef] [PubMed]
[25] He, Y.Q., Chen, A.L., Xu, W.B., et al. (2013) Emergence, Circulation, and Spatiotemporal Phylogenetic Analysis of Coxsackievirus A6- and Coxsackievirus A10-Associated Hand, Foot, and Mouth Disease Infections from 2008 to 2012 in Shenzhen, China. Journal of Clinical Microbiology, 51, 3560-3566. [Google Scholar] [CrossRef
[26] Han, J.F., Xu, S., Zhang, Y., et al. (2014) Hand, Foot, and Mouth Disease Outbreak Caused by Coxsackievirus A6, China, 2013. Journal of Infection, 69, 303-305. [Google Scholar] [CrossRef] [PubMed]
[27] Tao, J., He, X.Y., Shi, Y., Zhu, G., Liu, S., Zhang, Z., et al. (2017) Epidemiology of 45,616 Suspectcases of Hand, Foot and Mouth Disease in Chongqing, China, 2011-2015. Scientific Reports, 7, Article No. 45630. [Google Scholar] [CrossRef] [PubMed]
[28] 于方圆, 朱汝南. 手足口病相关病原体柯萨奇病毒A6的研究进展[J]. 中国病毒病杂志, 2017, 7(6): 76-81.
[29] Li, Y., Xiong, T., Meng, Y., et al. (2020) Risk Factors for Severe Hand, Foot, and Mouth Disease Infected with Coxsackievirus A6: A Hospital-Based Case-Control Study. Journal of Medical Virology, 92. [Google Scholar] [CrossRef] [PubMed]
[30] Raqib, R., Alam, D.S., Sarker, P., et al. (2007) Low Birth Weight Is Associated with Altered Immune Function in Rural Bangladeshi Children: A Birth Cohort Study. The American Journal of Clinical Nutrition, 85, 845-852. [Google Scholar] [CrossRef] [PubMed]
[31] Peng, L., Luo, R. and Jiang, Z. (2017) Risk Factors for Neurogenic Pulmonary Edema in Patients with Severe Hand, Foot, and Mouth Disease: A Meta-Analysis. International Journal of Infectious Diseases, 65, 37-43. [Google Scholar] [CrossRef] [PubMed]
[32] Chen, S.M., Du, J.W., Jin, Y.M., et al. (2015) Risk Factors for Severe Hand Foot Mouth Disease in Children in Hainan, China, 2011-2012. Asia Pacific Journal of Public Health, 27, 715-722. [Google Scholar] [CrossRef] [PubMed]
[33] Zhang, D., Li, R., Zhang, W., et al. (2017) A Case-Control Study on Risk Factors for Severe Hand, Foot and Mouth Disease. Scientific Reports, 7, Article No. 40282. [Google Scholar] [CrossRef] [PubMed]
[34] Zhu, J. and Dingess, K.A. (2019) The Functional Power of the Human Milk Proteome. Nutrients, 11, 1834. [Google Scholar] [CrossRef] [PubMed]
[35] Wang, Y., Feng, Z., Yang, Y., et al. (2011) Hand, Foot, and Mouth Disease in China: Patterns of Spread and Transmissibility. Epidemiology, 22, 781-792. [Google Scholar] [CrossRef
[36] Ruan, F., Yang, T., Ma, H., et al. (2011) Risk Factors for Hand, Foot, and Mouth Disease and Herpangina and the Preventive Effect of Hand-Washing. Pediatrics, 127, e898-e904. [Google Scholar] [CrossRef] [PubMed]
[37] Zhang, D., Li, Z., Zhang, W., et al. (2016) Hand-Washing: The Main Strategy for Avoiding Hand, Foot and Mouth Disease. International Journal of Environmental Research and Public Health, 13, 610. [Google Scholar] [CrossRef] [PubMed]
[38] Fang, Y., Wang, S., Zhang, L., et al. (2014) Risk Factors of Severe Hand, Foot and Mouth Disease: A Meta-Analysis. Scandinavian Journal of Infectious Diseases, 46, 515-522. [Google Scholar] [CrossRef] [PubMed]
[39] Long, L., Gao, L.D., Hu, S.X., et al. (2016) Risk Factors for Death in Children with Severe Hand, Foot, and Mouth Disease in Hunan, China. Infectious Diseases, 48, 744-748. [Google Scholar] [CrossRef] [PubMed]
[40] Mao, Q.Y., Wang, Y., Bian, L., et al. (2016) EV71 Vaccine, a New Tool to Control Outbreaks of Hand, Foot and Mouth Disease (HFMD). Expert Review of Vaccines, 15, 599-606. [Google Scholar] [CrossRef] [PubMed]
[41] Zhu, F., Xu, W., Xia, J., et al. (2014) Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China. New England Journal of Medicine, 370, 818-828. [Google Scholar] [CrossRef
[42] Zhang, Z., Dong, Z., Wang, Q., et al. (2018) Characterization of an Inactivated Whole-Virus Bivalent Vaccine That Induces Balanced Protective Immunity against Coxsackievirus A6 and A10 in Mice. Vaccine, 36, 7095-7104. [Google Scholar] [CrossRef] [PubMed]
[43] Lim, H., In, H.J., Lee, J.A., et al. (2018) The Immunogenicity and Protection Effect of an Inactivated Coxsackievirus A6, A10, and A16 Vaccine against Hand, Foot, and Mouth Disease. Vaccine, 36, 3445-3452. [Google Scholar] [CrossRef] [PubMed]
[44] Li, Y., Zhang, J. and Zhang, X. (2014) Modeling and Preventive Measures of Hand, Foot and Mouth Disease (HFMD) in China. International Journal of Environmental Research and Public Health, 11, 3108-3117. [Google Scholar] [CrossRef] [PubMed]
[45] Brooks, D., et al. (2018) Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6 on the Rise. Cutis, 102, 353-356.
[46] Ventarola, D., Bordone, L. and Silverberg, N. (2015) Update on Hand-Foot-and-Mouth Disease. Clinics in Dermatology, 33, 340-346. [Google Scholar] [CrossRef] [PubMed]