CAR-T疗法在胃癌中的研究进展
Progress of CAR-T Therapy in Gastric Cancer
DOI: 10.12677/ACM.2022.124361, PDF,    科研立项经费支持
作者: 李 桃:西安医学院,陕西 西安;陕西省人民医院普外二科,陕西 西安;崔 童:西安医学院,陕西 西安;陕西省人民医院肿瘤内科,陕西 西安;王建华:陕西省人民医院普外二科,陕西 西安
关键词: 嵌合抗原受体T细胞胃癌免疫治疗Chimeric Antigen Receptor T Cell Gastric Cacer Immunotherapy
摘要: 继嵌合抗原受体T细胞(chimeric antigen receptor T cell, CAR-T)免疫疗法在血液系统肿瘤中取得显著成效之后,CAR-T疗法用于实体瘤亦逐渐成为研究热点。胃癌(GC)是最常见的消化道恶性肿瘤之一,是全球第三大癌症相关死亡原因。对于缺乏手术适应症及放疗、化疗效果不好的患者,迫切需要寻找新颖而高效的治疗方式。CAR-T疗法在胃癌的治疗中已取得一些成果,不过也存在一些需要克服的障碍。本文综述了CAR-T疗法在胃癌中的治疗现状及面临的挑战。
Abstract: Since chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved remarkable results in hematological tumors, CAR-T therapy has gradually become a hot topic in solid tumors. Gastric cancer is one of the most common types of cancer and the third leading cause of cancer-related death overall. It is urgent to find novel and efficient treatment methods for patients who lack surgical indications or those who with poor radiotherapy and chemotherapy outcomes. CAR-T therapy has made some achievements in the treatment of gastric cancer, but there are still some obstacles to overcome. This paper reviews the current status and challenges in CAR-T therapy for gastric cancer.
文章引用:李桃, 崔童, 王建华. CAR-T疗法在胃癌中的研究进展[J]. 临床医学进展, 2022, 12(4): 2500-2509. https://doi.org/10.12677/ACM.2022.124361

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