Sortilin蛋白在脂质代谢中的研究进展
Research Progress of Sortilin Protein in Lipid Metabolism
DOI: 10.12677/ACM.2022.124368, PDF,   
作者: 初星霖, 柯大智*：重庆医科大学附属第二医院全科医学科，重庆；刘 瑞：重庆医科大学附属第二医院肿瘤科，重庆
关键词: Sortilin；脂质代谢；胰岛素抵抗；Sortilin； Lipid Metabolism； Insulin Resistance
摘要: 血脂异常是导致各种心血管代谢疾病的重要危险因素，严重影响人类健康。Sortilin作为液泡分拣因子10结构域受体家族的一员，充当细胞的受体或共同受体，介导在细胞内靶向运输不同的蛋白质。它首次在人脑中发现，并广泛表达于神经元、肝细胞、脂肪细胞和巨噬细胞等。近年研究表明，sortilin与脂质代谢相关基因的表达、脂质的合成、转运、分解代谢等密切相关。Sortilin对脂质代谢的多重作用提示其有望作为心血管疾病等脂质代谢相关疾病的潜在治疗靶点。本文将对sortilin在脂质代谢中的作用作一综述。
Abstract: Dyslipidemia has been considered a key factor associated with a series of cardiovascular and metabolic diseases, which seriously affects human health. Sortilin, a member of the vacuolar protein sorting 10 protein (Vps10p) domain receptor family, acts as receptor or co-receptor, mediating the targeted transport of different proteins within cells. It was first discovered in the human brain and is widely expressed in neurons, hepatocytes, adipocytes, and macrophages. Recent studies have shown that sortilin is closely related to the expression of lipid metabolism-related genes, lipid synthesis, transport, and catabolism. The multiple effects of sortilin on lipid metabolism suggest that it may be a potential therapeutic target for lipid metabolism-related diseases such as cardiovascular disease. This article will review the role of sortilin in lipid metabolism.
文章引用：初星霖, 刘瑞, 柯大智. Sortilin蛋白在脂质代谢中的研究进展[J]. 临床医学进展, 2022, 12(4): 2552-2558. https://doi.org/10.12677/ACM.2022.124368

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