调节胃液酸碱度在预防重型颅脑损伤应激性溃疡出血中的作用

The Effect of Adjustment of Gastric Acidity and Alkalinity in Preventing Stress Ulcer Bleeding Caused by Severe Craniocerebral Injury

摘要: 目的：探讨胃内局部调节胃液酸碱度在预防重型颅脑损伤应激性溃疡出血中的作用。方法：将120例重型颅脑损伤患者采用随机数字表法随机分为试验组和对照组。每组60例，实验组测定胃液pH值；根据pH值结果给予干预措施，对照组常规使用质子泵抑制剂预防。结果：两组患者应激性溃疡出血发生率比较差异无统计学意义(P > 0.05)，试验组较对照组相关医疗费用明显降低，差异有统计学意义(P < 0.05)。结论：早期监测胃液pH值，根据pH值的变化及早采取预防措施，有早期预防治疗的作用，能显著降低医疗费用。

Abstract: Objective: To investigate the effect of local adjustment of gastric acidity and alkalinity in preventing stress ulcer bleeding caused by severe craniocerebral injury. Methods: 120 patients with severe craniocerebral injury were randomly divided into experimental group and control group. There were 60 cases in each group. The pH value of gastric juice was measured in the experimental group and interventions were given according to the pH results. The control group routinely received proton pump inhibitors. Results: There was no significant difference in the incidence of stress ulcer bleeding between the two groups (P > 0.05). Compared with the control group, the related medical expenses of the experimental group were significantly lower, and the difference was statistically significant (P < 0.05). Conclusion: Early monitoring of gastric pH value and taking preventive measures according to the change of pH value can have the effect of early prevention and significantly reduce medical costs.