成纤维细胞生长因子23与认知功能障碍的研究进展

Research Progress of Fibroblast Growth Factor 23 and Cognitive Impairment

摘要: 成纤维细胞生长因子23 (fibroblast growth factor 23, FGF23)是一种由骨细胞和成骨细胞合成的促磷酸激素，其主要发挥调节磷酸盐代谢、维生素D代谢、甲状旁腺激素生成、糖脂代谢等功能。认知功能是人脑接受外界信息，经过加工处理，转换为内在的心理活动，从而获取知识或应用知识的过程。它包括记忆、语言、视空间、执行、计算和理解判断等方面。认知功能障碍是上述几项认知功能中的一项或多项受损，出现记忆障碍、失语、失用、失认、视空间障碍、执行功能障碍、计算力障碍，严重者甚至痴呆，严重影响个体的日常或社会能力。FGF23与认知功能障碍的发生关系密切，深入研究FGF23与认知功能的关系对其预后具有重要意义。

Abstract: Fibroblast growth factor 23 (FGF23) is a phosphate promoting hormone synthesized by osteoblasts and osteoblasts. It mainly plays the functions of regulating phosphate metabolism, vitamin D metabolism, parathyroid hormone production, glucose and lipid metabolism. Cognitive function is a process in which the human brain receives external information, processes it and transforms it into internal psychological activities, so as to obtain knowledge or apply knowledge. It includes memory, language, visual space, execution, calculation, understanding and judgment. Cognitive impairment is the impairment of one or more of the above cognitive functions, including memory impairment, aphasia, apraxia, agnosia, visuospatial disorder, executive dysfunction, computational impairment, and even dementia, which seriously affects the individual’s daily or social ability. FGF23 is closely related to the occurrence of cognitive impairment. In-depth study of the relationship between FGF23 and cognitive function is of great significance for its prognosis.