Semaphorin 3A及相关分子对足细胞损伤的机制的研究进展
Research Progress on the Mechanism of Semaphorin 3A and Related Molecules on Podocytes Injury
DOI: 10.12677/ACM.2022.124415, PDF,   
作者: 于 霞：青海大学，青海 西宁 ；罗朋立：青海大学附属医院，青海 西宁
关键词: 信号素3A；肾病；尿足细胞；细胞信号；蛋白尿；细胞形态；Semaphorin 3A； Nephropathy； Urinary Podocyte； Podocyte Signaling； Proteinuria； Cell Morphology
摘要: SEMA3A的表达定位于远端小管和集合管的足细胞，SEMA3A是足细胞分泌的一种导向蛋白，在肾脏发育过程中，严密的SEMA3A调节对于维持肾小球滤过屏障的结构和功能异常重要。信号素3A (SEMA3A)被认为在足细胞上的裂隙横膈膜(缝隙横膈膜)维持中起着重要的作用。SEMA3A调节足细胞的形状，过多的SEMA3A信号会导致加重肾脏疾病。机制上，过量的SEMA3A在体内诱导肾素、MMP-9 (基质金属蛋白酶-9)和avb3整合素等的失调，SEMA3A通过下调相关受体破坏足细胞结构和功能，因此，SEMA3A是成年肾脏肾小球滤过屏障中足细胞的结构和功能的细胞外负调节器。本篇针对SEMA3A对足细胞形态及功能损伤机制进行综述。
Abstract: The expression of SEMA3A is localized in the podocytes of distal tubules and collecting ducts. SEMA3A is a guiding protein secreted by podocytes. In the process of renal development, strict SEMA3A regulation is important to maintain the abnormal structure and function of glomerular filtration barrier. Signal element 3A (SEMA3A) is considered to play an important role in the maintenance of slit diaphragm on podocytes. SEMA3A regulates the shape of podocytes. Too many SEMA3A signals can aggravate kidney disease. In terms of mechanism, excessive SEMA3A induces the imbalance of renin, MMP-9 and avb3 integrin in vivo, and SEMA3A automatically destroys the shape of podocytes. SEMA3A is an extracellular negative regulator of the structure and function of podocytes in the glomerular filtration barrier of adult kidney. This article reviews the mechanism of SEMA3A on podocyte morphology and function injury.
文章引用：于霞, 罗朋立. Semaphorin 3A及相关分子对足细胞损伤的机制的研究进展[J]. 临床医学进展, 2022, 12(4): 2887-2892. https://doi.org/10.12677/ACM.2022.124415

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