Bronsted酸催化串联反应一锅制备3-氨基-1-茚酮
Bronsted Acid-Catalyzed One-Pot Synthesis of 3-Aminoindan-1-Ones through a Domino Reaction
DOI: 10.12677/JOCR.2022.102004, PDF,    科研立项经费支持
作者: 翟伍超, 刘家璇, 闫佳玉, 杜美烨, 吕 新*, 康红兰*:浙江师范大学化学与生命科学学院,先进催化材料教育部重点实验室,浙江 金华
关键词: 3-氨基-1-茚酮酸催化串联反应邻炔基苯甲醛一锅合成3-Aminoindan-1-One Acid-Catalyzed Domino Reaction O-Ethynylbenzaldehyde One-Pot Synthesis
摘要: 本文主要研究了在有机Bronsted酸催化条件下,由邻乙炔基苯甲醛与环状脂肪仲胺经烯胺化/环化/水解串联反应一锅合成3-氨基-1-茚酮类化合物。该方法具有原料易得、底物适用范围广(各种取代的邻乙炔苯甲醛和环状仲胺均可顺利参与)、产率高(81%~97%)、时间较短(5~9 h)、可放大量制备(20 mmol规模)、一锅合成方式操作便捷等优势。
Abstract: The paper demonstrates the one-pot synthesis of 3-aminoindan-1-ones through the domino enamidation/cyclization/hydrolysis reactions between o-ethynylbenzaldehydes and cyclic aliphatic amines under organic Bronsted acid catalysis. This method possesses many merits, such as the readily available starting materials, broad substrate scope (various substituted o-ethynylbenzaldehydes and cyclic aliphatic amines participated in the reaction successfully), high yields (81%~97%), short reaction time (5~9 h), scalability (20 mmol scale), and convenient one-pot synthetic procedures.
文章引用:翟伍超, 刘家璇, 闫佳玉, 杜美烨, 吕新, 康红兰. Bronsted酸催化串联反应一锅制备3-氨基-1-茚酮[J]. 有机化学研究, 2022, 10(2): 39-49. https://doi.org/10.12677/JOCR.2022.102004

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