MPV、PDW及FIB与糖尿病微血管病变的研究进展

Research Progress of MPV, PDW and FIB in Diabetic Microangiopathy

摘要: 糖尿病(diabetes mellitus, DM)患者的平均血小板体积(mean platelet volume, MPV)、血小板体积分布宽度(platelet volume distribution width, PDW)及纤维蛋白原(fibrinogen, FIB)与正常人相比会发生变化，近年来，多项研究显示这些变化与糖尿病微血管病变的发生发展有关，可能是糖尿病微血管病变的危险因素。大多指南中明确指出了糖尿病微血管病变发生的主要危险因素，包括DM病程较长、血糖控制不达标、高血压、血脂紊乱、吸烟以及胰岛素抵抗等，这些危险因素在DM的治疗中都会被注意到，而患者的MPV、PDW及FIB却很少被关注，也不会给予相应的干预措施。若临床医生能意识到MPV、PDW及FIB与糖尿病微血管病变的关系，或许能有效地降低这一危险因素的作用。现就MPV、PDW及FIB与糖尿病微血管病变相关性的研究现状作一综述。

Abstract: The mean platelet volume (MPV), platelet volume distribution width (PDW) and fibrinogen (FIB) in patients with diabetes mellitus (DM) are changed compared with normal persons. In recent years, many studies have shown that these changes are related to the occurrence and development of diabetic microangiopathy. It may be a risk factor for diabetic microangiopathy. Most of the guidelines clearly point out the main risk factors of diabetic microangiopathy, including long course of DM, non-standard blood glucose control, hypertension, dyslipidemia, smoking and insulin resistance. These risk factors will be noticed in the treatment of DM, while MPV, PDW and FIB of patients are rarely concerned, nor will they be given corresponding intervention measures. If clinicians can be aware of the relationship between MPV, PDW and FIB and diabetic microangiopathy, it may be effective in reducing this risk factor. This article reviews the current research status of MPV, PDW and FIB in relation to diabetic microangiopathy.