YY1蛋白在血液肿瘤中的研究进展
Research Progress of YY1 Protein in Hematologic Malignancies
DOI: 10.12677/ACM.2022.124439, PDF,    科研立项经费支持
作者: 曹庆艳：大理大学临床医学院，云南 大理；李永萍*：大理大学第一附属医院，云南 大理
关键词: YY1蛋白；白血病；淋巴瘤；多发性骨髓瘤；YY1 Protein； Leukemia； Lymphoma； Multiple Myeloma
摘要: YY1蛋白是一种具有锌指结构的多功能DNA结合蛋白，现发现其与血液肿瘤的发生发展密切相关。YY1蛋白与肿瘤细胞的目的基因或蛋白因子结合，在肿瘤的增殖、转录调控、代谢重编程、耐药等一系列的生物学过程中发挥激活或者抑制的双重作用。近年来，血液系统恶性肿瘤成为最常见的恶性肿瘤之一，因此本文总结YY1蛋白在血液肿瘤中的生物学功能，阐述YY1蛋白在血液肿瘤中的相关关系，就YY1蛋白在血液肿瘤中的研究进展作一综述。
Abstract: The YY1 protein is a multifunctional DNA-binding protein with a zinc-finger structure, the present study found that it’s closely related to the occurrence and development of hematological malignancies. YY1 protein binds to the target genes or protein factors of tumor cells, and plays a dual role of activation or inhibition in a series of biological processes, such as tumor proliferation, transcriptional regulation, metabolic reprogramming, and drug resistance. In recent years, hematological malignancies have become one of the most common malignancies, so this paper summarizes the biological function of YY1 protein in hematological malignancies, expounds the correlation of YY1 protein in hematological malignancies, and summarizes the research progress of YY1 protein in hematological malignancies.
文章引用：曹庆艳, 李永萍. YY1蛋白在血液肿瘤中的研究进展[J]. 临床医学进展, 2022, 12(4): 3047-3052. https://doi.org/10.12677/ACM.2022.124439

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