重组人生长激素治疗烧伤的研究进展

Research Progress in the Treatment of Burn with Recombinant Human Growth Hormone

摘要: 严重烧伤患者的数量日益增高，针对严重烧伤患者的治疗和预后非常重要，严重烧伤后常可导致患者的免疫系统受到破坏，全身多器官功能衰竭，以及严重应激反应、炎症反应、负氮平衡，可引起创面的感染和发热。烧伤患者伤后分解代谢增强，蛋白质分解加快，导致全身肌肉、脂肪等组织消耗增加。重组人生长激素(rhGH)可调节增加创面胶原蛋白沉积，加快创面愈合速度，增加氮、磷、钾储备，抑制蛋白质分解，促进蛋白质合成，故而可以纠正烧伤病人负氮平衡状态和低蛋白血症。还可抑制炎性反应从而抑制肠源性感染。

Abstract: The number of patients with severe burns is increasing. The treatment and prognosis of severe burns are very important. Severe burns can often lead to the destruction of the patient’s immune system, systemic multiple organ failure, and severe stress, inflammation, and negative nitrogen balance which can cause infection and fever on the wound. After burn, catabolism is enhanced and protein decomposition is accelerated, resulting in increased consumption of muscle, fat and other tissues of the whole body. Recombinant human growth hormone (rhGH) can regulate and increase collagen deposition on wound surface, speed up wound healing, increase nitrogen, phosphorus and potassium reserves, inhibit protein decomposition, promote protein synthesis, thus correcting negative nitrogen balance and hypoproteinemia in burn patients. It can also inhibit the inflammatory response and thereby inhibit intestinal infections.