实体肿瘤循环肿瘤细胞及其EMT分型临床研究进展

Advances in Clinical Research on Solid Tumor Circulating Tumor Cells and Their EMT Typing

摘要: 进入人体外周血的肿瘤细胞称为循环肿瘤细胞，循环肿瘤细胞CTC可引起新的转移病灶。既往相关检测方法缺乏灵敏度及时效性，循环肿瘤细胞(CTC)检测技术作为近年兴起的液态活检技术，具有实时、方便、准确、微创的特点，对肿瘤诊断、临床分期、方案制定、疗效及预后评价均具有重要意义；同时，外周血中CTC检测，有助于更准确评估患者病情及分期，为肿瘤诊断提供证据，判断患者预后，评估治疗反应的有效性，在患者出现耐药时及时反馈信息，有助于及时改变治疗策略，做到肿瘤的精准医疗；可真实反映肿瘤负荷和特征，动态反映肿瘤基因组学信息和基因表达谱变化，因此CTC不仅目前批准用于肿瘤筛查和诊断，也在肿瘤治疗和预后评估中具有重要作用。

Abstract: Tumor cells entering human peripheral blood are called circulating tumor cells, and circulating tumor cell CTC can cause new metastatic lesions. Previous detection methods lack sensitivity and timeliness. Circulating tumor cell (CTC) detection technology, as a liquid biopsy technology emerging in recent years, is real-time, convenient, accurate and minimally invasive, which is of great significance for tumor diagnosis, clinical staging, protocol formulation, efficacy and prognosis evaluation. At the same time, the detection of CTC in peripheral blood can help to more accurately evaluate the patient's condition and stage, provide evidence for tumor diagnosis, judge the patient's prognosis, evaluate the effectiveness of treatment response, and provide timely feedback in the case of drug resistance in patients, which is conducive to timely change of treatment strategy and achieve accurate cancer medicine. CTC can truly reflect tumor load and characteristics, and dynamically reflect changes in tumor genomic information and gene expression profile. Therefore, CTC is not only currently approved for tumor screening and diagnosis, but also plays an important role in tumor treatment and prognosis evaluation.