胶原蛋白材料对创面愈合的研究进展

Research Progress of Collagen Material on Wound Healing

摘要: 由于感染的参与和严重程度，创面愈合一直是外科医生所关注的问题。因此，创面的愈合总是需要付出额外的努力来管理并随后从伤口部位去除瘢痕。创面处理的基本原则是保持创面清洁、无污染，减轻创面疼痛，减少创面渗出与水肿，预防创面损伤加重，防止创面感染以及促进创面早期愈合。多年以来，外科医师一直在寻找符合上述治疗原则的材料或药物。近年来，生物材料在慢性创面治疗中的作用已得到充分证实。其中一种生物材料是胶原蛋白，它被认为是大多数用于创面愈合配方的关键成分。在这里，我们主要介绍基于胶原蛋白的生物材料用于创面愈合的最新进展，以期为创面愈合的临床研究提供可靠的理论依据和治疗理念。

Abstract: Because of the involvement and severity of infection, wound healing has always been a concern of surgeons. As a result, wound healing always requires extra effort to manage and then remove the scar from the wound site. The basic principle of wound treatment is to keep the wound clean and pollution-free, relieve the wound pain, reduce the wound exudation and edema, prevent the ag-gravation of wound injury, prevent wound infection and promote the early healing of wound. For years, surgeons have been searching for materials or drugs that fit these principles. In recent years, the role of biomaterials in the treatment of chronic wounds has been fully confirmed. One such biomaterial is collagen, which is considered a key ingredient in most wound healing formulations. Here, we mainly introduce the latest progress of collagen-based biomaterials for wound healing, in order to provide reliable theoretical basis and therapeutic concept for clinical research on wound healing.