重组人表皮生长因子在医学领域的应用
Application of Recombinant Human Epidermal Growth Factor in Medical Field
DOI: 10.12677/ACM.2022.124477, PDF,   
作者: 张静娴：青海大学，青海 西宁；马文宇：青海大学附属医院，青海 西宁
关键词: 重组人表皮生长因子；医学应用；Recombinant Human Epidermal Growth Factor； Medical Application
摘要: 重组人表皮生长因子(recombinant human Epidermal Growth Factor, rhEGF)是一种低分子多肽，它具有广泛的生物活性，它与特定的高亲和力细胞膜受体结合并调节细胞生长和其他细胞功能，例如多肽和其他多效性物质。在过去的几十年里，它被用于治疗烧伤、溃疡、各种创伤和角膜损伤。近年来逐渐引起了重视，在改善瘢痕及色素沉着等方面有了新的应用。它还促进正常表皮细胞的新陈代谢，从而产生美白和抗皱、抗衰老的效果。本综述的目的是论述目前rhEGF (recombinant human Epidermal Growth Factor)在医学领域中的临床应用及其未来的展望。
Abstract: Recombinant human epidermal growth factor (rhEGF) is a low molecular polypeptide. It has a wide range of biological activities. It binds to specific high affinity cell membrane receptors and regulates cell growth and other cell functions, such as polypeptides and other pleiotropic substances. In the past decades, it has been used to treat burns, ulcers, various wounds and corneal injuries. In recent years, it has gradually attracted attention, and has new applications in improving scar and pigmentation. It also promotes the metabolism of normal epidermal cells, resulting in whitening, anti wrinkle and anti-aging effects. The purpose of this review is to discuss the clinical application and future prospect of rhEGF in the field of medicine.
文章引用：张静娴, 马文宇. 重组人表皮生长因子在医学领域的应用[J]. 临床医学进展, 2022, 12(4): 3311-3315. https://doi.org/10.12677/ACM.2022.124477

参考文献

[1] Laato, M., Kahari, V.M., Niinikoshi, J., et al. (1987) Epidermal Growth Factor Increases Collagen Production in Gran-ulation Tissue by Stimulation of Fibroblast Proliferation and Not by Activation of Procollagen Genes. Biochemical Journal, 247, 385-388. [Google Scholar] [CrossRef] [PubMed]
[2] 付小兵, 孙晓庆, 孙同柱, 等. 表皮细胞生长因子通过诱导皮肤干细胞分化加速受创表皮再生的研究[J]. 中国修复重建外科杂志, 2002, 16(1): 31-35.
[3] Nguyen, T. and Razzaque Ahmed, A. (2016) Autoimmune Progesterone Dermatitis: Update and Insights. Autoimmunity Reviews, 15, 191-197. [Google Scholar] [CrossRef] [PubMed]
[4] 张秀丽, 张理涛. rhEGF凝胶对面部激素依赖性皮炎皮肤功能改善的临床研究[J]. 天津医药, 2016, 44(5): 629-631.
[5] 李静华, 张志明, 滕志青, 等. 超脉冲二氧化碳点阵激光面部换肤治疗的临床观察[J]. 中国药物经济学, 2014, 6(7): 123-124.
[6] Kim, M.S., Song, H.J., Lee, C.K., et al. (2014) Comparative Study of Various Growth Factors and Cy-tokines on Type I Collagen and Hyaluronan Production in Human Dermal Fibroblasts. Journal of Cosmetic Dermatology, 13, 44-51. [Google Scholar] [CrossRef] [PubMed]
[7] 崔振华, 周学辉, 赵虎林, 等. 中度烧伤患者深II度烧伤创面血清EPO水平表达的临床意义[J]. 现代生物医学进展, 2015, 15(31): 6112-6115.
[8] 韩悦, 任杰, 伍锦华, 等. 重组人表皮生长因子联合磺胺嘧啶锌凝胶治疗深II度烧伤创面的疗效观察[J]. 广西医科大学学报, 2017, 34(9): 1354-1357.
[9] 蒋屏东, 孙慧. 重组人表皮生长因子在面部瘢痕修复治疗中的应用[J]. 现代生物医学进展, 2017, 33(23): 6502-6504.
[10] 祝霞, 孙丽玲. 强脉冲光联合重组人表皮生长因子凝胶治疗面部激素依赖性皮炎的疗效观察[J]. 中国现代医学杂志, 2017, 27(2): 91-93.
[11] 陈明华, 余红春, 雷丽婵, 等. 重组人表皮生长因子凝胶与康复新液治疗III级放射性皮炎的疗效观察[J]. 实用临床医药杂志, 2013, 17(1): 95-97.
[12] 赵霞, 王英壮. 玻璃酸钠联合重组人表皮生长因子滴眼液治疗白内障术后干眼症的临床效果[J]. 宁夏医科大学学报, 2018, 40(5): 575-578.
[13] 田莉, 吴永红. 玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究[J]. 中国全科医学, 2017, 20(7): 164-166.
[14] 杨菁, 金文芳, 等. 重组人表皮生长因子对受损人子宫内膜间质细胞的修复作用研究[J]. 中国实用妇科与产科杂志, 2021, 37(9): 959-963.
[15] Mirdailami, O., Soleimani, M., Dinarvand, R., et al. (2015) Controlled Release of rhEGF and rhbFGF from Electrospun Scaffolds for Skin Regeneration. Journal of Biomedical Materials Research Part A, 103, 3374-3385. [Google Scholar] [CrossRef] [PubMed]
[16] Kim, J.M., Ji, J.H., Kim, Y.S., et al. (2020) rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects. Cancers, 12, 3120-3137. [Google Scholar] [CrossRef] [PubMed]
[17] Gainza, G., Pastor, M., Aguirre, J.J., et al. (2014) A Novel Strategy for the Treatment of Chronic Wounds Based on the Topical Administration of rhEGF-Loaded Lipid Nanopartlcles: In vitro Bioactivity and in vivo Effectiveness in Healing-Impaired db/db Mice. Journal of Controlled Release, 185, 51-61. [Google Scholar] [CrossRef] [PubMed]
[18] Maeng, J.H., So, J.W., Kim, J., et al. (2014) rhEGF-Containing Thermosensitive Mucoadhesive Polymeric Sol-Gel for Endoscopic Treatment of Gastric Ulcer Bleeding. Journal of Biomaterials Applications, 28, 1113-1121. [Google Scholar] [CrossRef] [PubMed]
[19] 朱胜章, 陆建波, 王京晔, 等. EGF诱导结肠腺癌HCT-116细胞神经内分泌分化实验[J]. 昆明医科大学学报, 2017, 38(7): 45-49.
[20] Kiyatkin, A., van Alderwerelt van Rosenburgh, I.K., Klein, D.E., et al. (2020) Kinetics of Receptor Tyrosine Kinase Activation Define ERK Signaling Dynamics. Science Signaling, 13, 5267-5293. [Google Scholar] [CrossRef] [PubMed]

为你推荐