微流控器件制作与应用的研究进展
Research Progress of Fabrication and Applications in Microfluidic Devices
DOI: 10.12677/AAC.2022.122007, PDF,   
作者: 施浩杰*, 黄嘉欣:上海理工大学光电信息与计算机工程学院,上海
关键词: 微流控制造技术生物医学应用Microfluidic Fabrication Techniques Biomedical Applications
摘要: 微流体是一个相对崭新的领域,它基于物理学、化学、生物学、流体动力学、微电子学和材料科学等学科融合发展而成。许多材料可以加工成微型芯片,其中包含微尺度范围内的通道和腔室。可以选择多种方法来制造具有所需尺寸和几何形状的平台。单独使用或是通过与其他设备结合使用,微流控芯片可用于纳米颗粒制备、药物封装、细胞分析和细胞培养等。本文从制造技术的角度介绍了微流控技术,同时介绍了这些设备的生物医学应用。
Abstract: Microfluidics is a relatively new field based on the integration of physics, chemistry, biology, fluid dynamics, microelectronics and materials science. Many materials can be processed into microchips which contain channels and chambers on a microscale scale. There are a number of options to fabricate platforms with the desired size and geometry. Used alone or in combination with other devices, microfluidic chips can be used for nanoparticle preparation, drug packaging, cell analysis and cell culture. This paper describes microfluidic technology in terms of manufacturing techniques, as well as the biomedical applications of these devices.
文章引用:施浩杰, 黄嘉欣. 微流控器件制作与应用的研究进展[J]. 分析化学进展, 2022, 12(2): 47-52. https://doi.org/10.12677/AAC.2022.122007

参考文献

[1] Whitesides, G.M. (2006) The Origins and the Future of Microfluidics. Nature, 442, 368-373.
[Google Scholar] [CrossRef] [PubMed]
[2] Shrimal, P., Jadeja, G. and Patel, S. (2020) A Review on Novel Methodologies for Drug Nanoparticle Preparation: Microfluidic Approach. Chemical Engineering Research and Design, 153, 728-756.
[Google Scholar] [CrossRef
[3] Hamdallah, S.I., Zoqlam, R., Erfle, P., Blyth, M., Alkilany, A.M., Dietzel, A., et al. (2020) Microfluidics for Pharmaceutical Nanoparticle Fabrication: The Truth and the Myth. International Journal of Pharmaceutics, 584, Article ID: 119408.
[Google Scholar] [CrossRef] [PubMed]
[4] Song, Y., Hormes, J. and Kumar, C.S. (2008) Microfluidic Synthesis of Nanomaterials. Small, 4, 698-711.
[Google Scholar] [CrossRef] [PubMed]
[5] Agarwal, P., Wang, H., Sun, M., Xu, J., Zhao, S., Liu, Z., et al. (2017) Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery. ACS Nano, 11, 6691-702.
[Google Scholar] [CrossRef] [PubMed]
[6] Liu, Y. and Jiang, X. (2017) Why Microfluidics? Merits and Trends in Chemical Synthesis. Lab on a Chip, 17, 3960-3978.
[Google Scholar] [CrossRef
[7] Ma, J., Lee, S.M., Yi, C. and Li, C.W. (2017) Controllable Synthesis of Functional Nanoparticles by Microfluidic Platforms for Biomedical Applications—A Review. Lab on a Chip, 17, 209-226.
[Google Scholar] [CrossRef
[8] Liao, S., He, Y., Chu, Y., Liao, H. and Wang, Y. (2019) Solvent-Resistant and Fully Recyclable Perfluoropolyether-Based Elastomer for Microfluidic Chip Fabrication. Journal of Materials Chemistry A, 7, 16249-16256.
[Google Scholar] [CrossRef
[9] Hwang, J., Cho, Y.H., Park, M.S. and Kim, B.H. (2019) Microchannel Fabrication on Glass Materials for Microfluidic Devices. International Journal of Precision Engineering and Manufacturing, 20, 479-495.
[Google Scholar] [CrossRef
[10] Nielsen, J.B., Hanson, R.L., Almughamsi, H.M., Pang, C., Fish, T.R. and Woolley, A.T. (2020) Microfluidics: Innovations in Materials and Their Fabrication and Functionalization. Analytical Chemistry, 92, 150-168.
[Google Scholar] [CrossRef] [PubMed]
[11] Waldbaur, A., Rapp, H., Länge, K. and Rapp, B.E. (2011) Let There Be Chip—Towards Rapid Prototyping of Microfluidic Devices: One-Step Manufacturing Processes. Analytical Methods, 3, 2681-2716.
[Google Scholar] [CrossRef
[12] Guckenberger, D.J., De Groot, T.E., Wan, A.M., Beebe, D.J. and Young, E.W. (2015) Micromilling: A Method for Ultra-Rapid Prototyping of Plastic Microfluidic Devices. Lab on a Chip, 15, 2364-2378.
[Google Scholar] [CrossRef
[13] Iliescu, C., Taylor, H., Avram, M., Miao, J. and Franssila, S. (2012) A Practical Guide for the Fabrication of Microfluidic Devices Using Glass and Silicon. Biomicrofluidics, 6, Article ID: 016505.
[Google Scholar] [CrossRef] [PubMed]
[14] Bruijns, B., Van Asten, A., Tiggelaar, R. and Gardeniers, H. (2016) Microfluidic Devices for Forensic DNA Analysis: A Review. Biosensors, 6, Article No. 41.
[Google Scholar] [CrossRef] [PubMed]
[15] Baker, C.A., Bulloch, R. and Roper, M.G. (2011) Comparison of Separation Performance of Laser-Ablated and Wet-etched Microfluidic Devices. Analytical and Bioanalytical Chemistry, 399, 1473-1479.
[Google Scholar] [CrossRef] [PubMed]
[16] Faustino, V., Catarino, S.O., Lima, R. and Minas, G. (2016) Biomedical Microfluidic Devices by Using Low-Cost Fabrication Techniques: A Review. Journal of Biomechanics, 49, 2280-2292.
[Google Scholar] [CrossRef] [PubMed]
[17] Gale, B., Jafek, A., Lambert, C., Goenner, B., Moghimifam, H., Nze, U., et al. (2018) A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects. Inventions, 3, Article No. 60.
[Google Scholar] [CrossRef
[18] Attia, U.M., Marson, S. and Alcock, J.R. (2009) Micro-injection Moulding of Polymer Microfluidic Devices. Microfluidics and Nanofluidics, 7, Article No. 1.
[Google Scholar] [CrossRef
[19] Kotz, F., Risch, P., Helmer, D. and Rapp, B.E. (2019) High-Performance Materials for 3D Printing in Chemical Synthesis Applications. Advanced Materials, 31, Article ID: e1805982.
[Google Scholar] [CrossRef] [PubMed]
[20] Kotz, F., Risch, P., Helmer, D. and Rapp, B.E. (2018) Highly Fluorinated Methacrylates for Optical 3D Printing of Microfluidic Devices. Micromachines, 9, Article No. 115.
[Google Scholar] [CrossRef] [PubMed]
[21] Wang, S., Tasoglu, S., Chen, P.Z., Chen, M., Akbas, R., Wach, S., et al. (2014) Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care. Scientific Reports, 4, Article No. 3796.
[Google Scholar] [CrossRef] [PubMed]
[22] Pranzo, D., Larizza, P., Filippini, D. and Percoco, G. (2018) Extrusion-Based 3D Printing of Microfluidic Devices for Chemical and Biomedical Applications: A Topical Review. Micromachines, 9, Article No. 374.
[Google Scholar] [CrossRef] [PubMed]
[23] Colic, M., Tomic, S., Rudolf, R., Markovic, E. and Scepan, I. (2016) Differences in Cytocompatibility, Dynamics of the Oxide Layers’ Formation, and Nickel Release between Superelastic and Thermo-Activated Nickel-Titanium Archwires. Journal of Materials Science: Materials in Medicine, 27, Article No. 128.
[Google Scholar] [CrossRef] [PubMed]
[24] Rivet, C., Lee, H., Hirsch, A., Hamilton, S. and Lu, H. (2011) Microfluidics for Medical Diagnostics and Biosensors. Chemical Engineering Science, 66, 1490-1507.
[Google Scholar] [CrossRef
[25] Zhang, D., Bi, H., Liu, B. and Qiao, L. (2018) Detection of Pathogenic Microorganisms by Microfluidics Based Analytical Methods. Analytical Chemistry, 90, 5512-5520.
[Google Scholar] [CrossRef] [PubMed]
[26] Fan, H.C., Blumenfeld, Y.J., El-Sayed, Y.Y., Chueh, J. and Quake, S.R. (2009) Microfluidic Digital PCR Enables Rapid Prenatal Diagnosis of Fetal Aneuploidy. American Journal of Obstetrics and Gynecology, 200, 543.e1-7.
[Google Scholar] [CrossRef] [PubMed]
[27] Le Roux, D., Root, B.E., Hickey, J.A., Scott, O.N., Tsuei, A., Li, J., et al. (2014) An Integrated Sample-in-answer-out Microfluidic Chip for Rapid Human Identification by STR Analysis. Lab on a Chip, 14, 4415-4425.
[Google Scholar] [CrossRef
[28] Williams, M.J., Lee, N.K., Mylott, J.A., Mazzola, N., Ahmed, A. and Abhyankar, V.V. (2019) A Low-Cost, Rapidly Integrated Debubbler (RID) Module for Microfluidic Cell Culture Applications. Micromachines, 10, Article No. 360.
[Google Scholar] [CrossRef] [PubMed]
[29] Oh, K.W. (2020) Microfluidic Devices for Biomedical Applications: Biomedical Microfluidic Devices 2019. Micromachines, 11, Article No. 370.
[Google Scholar] [CrossRef] [PubMed]
[30] Lee, H., Chae, S., Kim, J.Y., Han, W., Kim, J., Choi, Y., et al. (2019) Cell-Printed 3D Liver-on-a-Chip Possessing a Liver Microenvironment and Biliary System. Biofabrication, 11, Article ID: 025001.
[Google Scholar] [CrossRef] [PubMed]
[31] Hassan, S., Sebastian, S., Maharjan, S., Lesha, A., Carpenter, A.M., Liu, X., et al. (2020) Liver-on-a-Chip Models of Fatty Liver Disease. Hepatology, 71, 733-740.
[Google Scholar] [CrossRef] [PubMed]
[32] Baydoun, M., Treizeibre, A., Follet, J., Vanneste, S.B., Creusy, C., Dercourt, L., et al. (2020) An Interphase Microfluidic Culture System for the Study of ex Vivo Intestinal Tissue. Micromachines, 11, Article No. 150.
[Google Scholar] [CrossRef] [PubMed]
[33] Yin, L., Zhang, H., Yang, S.-M. and Zhang, W. (2019) A Three-Layer Microfluidic Kidney Chip for Drug Nephrotoxicity Test. International Journal of Bioscience, Biochemistry and Bioinformatics, 9, 237-247.
[Google Scholar] [CrossRef
[34] Agnello, S., Gasperini, L., Reis, R.L., Mano, J.F., Pitarresi, G., Palumbo, F.S., et al. (2016) Microfluidic Production of Hyaluronic Acid Derivative Microfibers to Control Drug Release. Materials Letters, 182, 309-313.
[Google Scholar] [CrossRef
[35] Zheng, L., Cai, G., Wang, S., Liao, M., Li, Y. and Lin, J. (2019) A Microfluidic Colorimetric Biosensor for Rapid Detection of Escherichia coli O157:H7 Using Gold Nanoparticle Aggregation and Smart Phone Imaging. Biosens Bioelectron, 124-125, 143-149.
[Google Scholar] [CrossRef] [PubMed]
[36] Galan, E.A., Zhao, H., Wang, X., Dai, Q., Huck, W.T.S. and Ma, S. (2020) Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine. Matter, 3, 1893-1922.
[Google Scholar] [CrossRef
[37] Rackus, D.G., Riedel-Kruse, I.H. and Pamme, N. (2019) “Learning on a Chip”: Microfluidics for Formal and Informal Science Education. Biomicrofluidics, 13, Article ID: 041501.
[Google Scholar] [CrossRef] [PubMed]