中枢性性早熟女童嗅球体积的磁共振成像研究
Magnetic Resonance Imaging Study of Olfactory Bulb Volume in Girls with Central Precocious Puberty
DOI: 10.12677/ACM.2022.125543, PDF,    科研立项经费支持
作者: 陈 垒*：蚌埠医学院研究生院，安徽 蚌埠；张欣贤：徐州市儿童医院，江苏 徐州；夏丹丹：徐州市中心医院，江苏 徐州；李德春#：蚌埠医学院研究生院，安徽 蚌埠；徐州市中心医院，江苏 徐州
关键词: 磁共振成像；嗅球；嗅球体积；中枢性性早熟；Magnetic Resonance Imaging； Olfactory Bulb； Olfactory Bulb Volume； Central Precocious Puberty
摘要: 目的：采用磁共振成像探究中枢性性早熟(central precocious puberty, CPP)女童与健康女童左右侧及总嗅球体积大小之间有无差异。方法：选取2020年1月~2021年12月在徐州市中心医院及徐州市儿童医院临床诊断为CPP女童30例的MRI嗅球图像资料、收集相关临床资料，并选取同期健康女童40例的MRI嗅球图像资料。图像的采集均使用GE DISCOVERY MR750 3.0T磁共振，在冠状位T2加权FSE序列对嗅球进行扫描；得到的嗅球图像应用手工勾勒每层嗅球面积相加后乘以层厚得到总嗅球体积，并采用体表面积对嗅球体积进行校正。结果：CPP女童左侧嗅球体积为(27.95 ± 3.42) mm3、右侧嗅球体积为(27.61 ± 3.57) mm3、总嗅球体积为(55.56 ± 6.83) mm3；健康女童左侧嗅球体积为(24.27 ± 4.83) mm3、右侧嗅球体积为(23.70 ± 4.53) mm3、总嗅球体积为(47.97 ± 8.98) mm3，CPP女童与健康女童左侧、右侧及总嗅球体积的差异具有统计学意义(p < 0.05)。结论：CPP女童嗅球体积大于健康女童嗅球体积。
Abstract: Objective: To investigate whether there is any difference between the left and right side and total olfactory bulb volume size of girls with central precocious puberty (CPP) and healthy girls using magnetic resonance imaging. Methods: The MRI olfactory bulb image data of 30 girls clinically diagnosed with CPP in Xuzhou Central Hospital and Xuzhou Children’s Hospital from January 2020 to December 2021 were selected, and the MRI olfactory bulb images of 40 healthy girls in the same period were collected. The images were acquired using GE DISCOVERY MR750 3.0T MRI, and the olfactory bulb was scanned in the coronal T2-weighted FSE sequence along with the conventional pituitary scan. The obtained olfactory bulb images were summed by applying manual outlining of the area of each layer of the olfactory bulb and multiplied by the layer thickness to obtain the total olfactory bulb volume. Body surface area was used to correct the olfactory bulb volume. Results: The left olfactory bulb volume was (27.95 ± 3.42) mm3, the right olfactory bulb volume was (27.61 ± 3.57) mm3 and the total olfactory bulb volume was (55.56 ± 6.83) mm3 in CPP girls; The left olfactory bulb volume was (24.27 ± 4.83) mm3, the right olfactory bulb volume was (23.70 ± 4.53) mm3 and the total olfactory bulb volume was (47.97 ± 8.98) mm3 in healthy girls. The difference between the left side, right side and total olfactory bulb volume of CPP girls and healthy girls was statistically significant (p < 0.05). Conclusion: The olfactory bulb volume in girls with CPP is larger than that in healthy girls.
文章引用：陈垒, 张欣贤, 夏丹丹, 李德春. 中枢性性早熟女童嗅球体积的磁共振成像研究[J]. 临床医学进展, 2022, 12(5): 3762-3769. https://doi.org/10.12677/ACM.2022.125543

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