成纤维细胞生长因子19/15的表达调节与生物活性
Expression Regulation and Bioactivity of Fibroblast Growth Factor 19/15
摘要: FGF19(啮齿动物中FGF15)是内分泌FGF家族的成员之一,属于肠道激素,参与调节胆汁酸、葡萄糖和脂质代谢等,维持全身稳态。FGF19/15对多种慢性疾病具有治疗潜力,包括肥胖症、糖尿病和恶性癌症等。本文总结FGF19/15的表达调节及药理活性的研究进展,初步评估其临床应用潜力。
Abstract: FGF19 (FGF15 in rodents), a member of the endocrine FGF family, is an intestinal hormone involved in the regulation of bile acid, glucose and lipid metabolism to maintain systemic homeostasis. FGF19/15 has the potential to treat a variety of chronic diseases, including obesity, diabetes and malignant cancers. This paper reviews the biological activities of FGF19/15, and preliminarily evaluates the clinical application.
文章引用:白玉洁, 戴岳. 成纤维细胞生长因子19/15的表达调节与生物活性[J]. 药物资讯, 2022, 11(3): 161-167. https://doi.org/10.12677/PI.2022.113020

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