基于真实世界的喜炎平治疗轮状病毒性肠炎的疾病特征及用药特征分析

Treatment of Rotavirus Enteritis by Xiyanping Based on Real-World Clinical Disease Characteristics and Drug Use Characteristics

摘要: 目的：了解真实世界中，喜炎平治疗轮状病毒性肠炎的临床特征及用药特征。方法：采集真实世界使用喜炎平治疗的轮状病毒性肠炎1814名患者的基础信息、诊断资料、医嘱资料，经规范化处理后，运用频数统计、关联分析等方法分析数据中的患者年龄、性别；给药途径、剂量、疗程；合并疾病和合并用药等信息。结果：喜炎平治疗轮状病毒性肠炎以3岁以下的儿童为主，病情以一般为主；常合并疾病是轮状病毒肠炎和心脏疾病等；常用的给药途径是静脉滴注，静脉注射单日使用剂量最高未超过500 mg；常合并药物是磷酸肌酸。结论：喜炎平治疗轮状病毒性肠炎的临床用药较为规范。小儿病毒性肠炎感染容易并发心脏疾病、代谢疾病和上呼吸道感染等疾病，常合并磷酸肌酸、维生素类、西咪替丁、干扰素类、氨溴索等药物，以保护小儿心肌、增强抗病毒功效、治疗脱水、肺炎等并发症。

Abstract: Objective: In the real world, to acquaintance the clinical and medication characteristics of Xiyanping in the medical plan of rotavirus enteritis. Methods: The basic data, diagnostic data and medical advice of 1814 patients with rotavirus enteritis treated with Xiyanping in the real world were collected. Frequency statistics, correlation analysis were applied to analysis age, gender, route of administration, dosage, therapy session, complications and medication. Results: The treatment of rotavirus enteritis by Xiyanping was mainly in children under 3 years old, and the disease was generally; Rotavirus enteritis and heart disease were the two co-diseases. Intravenous drip is a common method of administration, and the daily dose of intravenous injection is not more than 500 mg. The single combined drugs were phosphocreatine. Conclusion: The clinical application of Xiyanping is relatively standar. It is often to be accompanied with heart disease, metabolic disease and upper respiratory tract infection. It is often combined with creatine phosphate, vitamins, cimetidine, interferon, ambroxol and other drugs to protect children’s myocardium, enhance antiviral effect, and treat complications such as dehydration and pneumonia.