中药复方制剂DM对阿尔茨海默病的临床短期效果观察研究
Study on the Short Term Therapeutic Effect of Chinese Medicine Compound Preparation DM-1 on Alzheimer’s Disease
DOI: 10.12677/PI.2022.113023, PDF,    科研立项经费支持
作者: 买吾拉尼江•依孜布拉：新疆医科大学中心实验室，新疆 乌鲁木齐;浙江大学脑科学脑医学学院，浙江 杭州；帕丽旦•吾术尔：新疆医科大学附属中医医院神志病科，新疆 乌鲁木齐；多力坤•马木特：新疆乌鲁木齐沙乐美生物科技有限公司，新疆 乌鲁木齐
关键词: 阿尔茨海默病；简易智能量表；神经精神量表；匹茨堡睡眠指数量表；Alzheimer’s Disease； Mini-Mental State Examination； Neuropsychiatric Inventory； Pittsburgh Sleep Quality Index
摘要: 目的：观察DM对阿尔茨海默病(AD)患者的短期治疗效果。方法：选取2016年6月~2017年6月期间在多力坤医生处就诊的30例AD病人，用中药复方制剂DM进行治疗。4周后观察AD患者简易智能量表(Mini-Mental State Examination, MMSE)、神经精神量表(Neuropsychiatric Inventory, NPI)分数及睡眠紊乱明显的AD患者匹茨堡睡眠指数量表(Pittsburgh Sleep Quality Index, PSQI)分数变化情况，并评估中药复方制剂DM对AD患者的疗效。结果：通过治疗四周后NPI和PSQI分数明显降低，MMSE分数明显增高，治疗前后差异均有统计学意义(P < 0.001)，并总有效率为86.7%。结论：DM药治疗对AD患者认知能力，精神状态以及睡眠质量的改善有显著的疗效。
Abstract: Objective: To observe the short-term therapeutic effect of DM-1 (DM-1 is a kind of traditional Chinese herb extractive, named DM-1 for the present) on Alzheimer’s disease. Methods: from June 2016 to June 2017, 30 cases of AD patients who were actively seeking for Dr. Dolkun were treated with DM-1. After 4 weeks, the changes in the score of Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI) of AD patients, and score of Pittsburgh Sleep Quality Index (PSQI) of AD patients with obvious sleep disorders were observed, and the effect of DM-1 drugs on AD pa-tients was evaluated. Results: The scores of NPI and PSQI decreased significantly, the MMSE score increased significantly after four weeks of treatment, the difference between before and after treatment was statistically significant (P < 0.001), the total effective rate was 86.7%. Conclusion: The preliminary results of this study suggest that DM-1 can significantly improve the learning and memory ability, mental state and sleep quality of patients with Alzheimer's disease in short-term.
文章引用：买吾拉尼江•依孜布拉, 帕丽旦•吾术尔, 多力坤•马木特. 中药复方制剂DM对阿尔茨海默病的临床短期效果观察研究[J]. 药物资讯, 2022, 11(3): 189-194. https://doi.org/10.12677/PI.2022.113023

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