NLR、MLR、FAR与AIS患者静脉溶栓治疗预后关系的研究进展
Research Progress on the Relationship between NLR, MLR, FAR and Prognosis of AIS Patients Treated with Intravenous Thrombolytic Therapy
摘要: NLR (中性粒细胞与淋巴细胞比值)、MLR (单核细胞与淋巴细胞比值)以及FAR (纤维蛋白原与白蛋白比值)作为新兴的炎症指标，与多种心脑血管疾病的发生、发展及其预后有关，已越来越多地应用于脑卒中患者发病及预后研究。但目前国内鲜有关于上述指标与AIS (急性缺血性脑卒中)患者静脉溶栓治疗预后关系相关研究，本文对NLR、MLR、FAR与AIS患者溶栓治疗预后相关性研究进行总结，以期为溶栓治疗患者不良预后早期干预提供参考。
Abstract: NLR (the ratio of neutrophils and lymphocytes), MLR (monocyte and lymphocyte ratio) and FAR (fi-brinogen and albumin ratio) as indicators of inflammation of the emerging, are associated with many kinds of occurrence, development and prognosis of disease of heart head blood-vessel, and have been increasingly used in the study of pathogenesis and prognosis of patients with cerebral apoplexy. However, there are few domestic studies on the correlation between the above indicators and the prognosis of intravenous thrombolytic therapy in patients with AIS (acute ischemic stroke). In this paper, the studies on the correlation between the prognosis of thrombolytic therapy in pa-tients with NLR, MLR, FAR and AIS were summarized, so as to provide reference for the early inter-vention of poor prognosis in patients with thrombolytic therapy.
文章引用：詹清艳, 霍燕, 薛艺东. NLR、MLR、FAR与AIS患者静脉溶栓治疗预后关系的研究进展[J]. 临床医学进展, 2022, 12(5): 3871-3879. https://doi.org/10.12677/ACM.2022.125560

参考文献

[1] Jayaraj, R.L., Azimullah, S., Beiram, R., et al. (2019) Neuroinflammation: Friend and Foe for Ischemic Stroke. Journal of Neuroinflammation, 16, 142. [Google Scholar] [CrossRef] [PubMed]
[2] Wang, Y., Jing, J., Meng, X., et al. (2019) The Third China National Stroke Registry (CNSR-III) for Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack: Design, Rationale and Baseline Patient Characteristics. Stroke and Vascular Neurology, 4, 158-164. [Google Scholar] [CrossRef] [PubMed]
[3] Jin, R., Liu, L., Zhang, S., et al. (2013) Role of Inflammation and Its Mediators in Acute Ischemic Stroke. Journal of Cardiovascular Translational Research, 6, 834-851. [Google Scholar] [CrossRef] [PubMed]
[4] 马翠红, 靳佳敏, 张俊莲, 等. 血常规中炎症指标在脑梗死预后中的预测价值[J]. 中风与神经疾病杂志, 2020, 37(8): 720-724.
[5] 徐恩君, 陈秋莉, 周龙荣, 等. 纤维蛋白原/白蛋白比值与脑梗死严重程度相关性分析[J]. 临床军医杂志, 2020, 48(12): 1444-1445, 1447.
[6] Schlemm, E., Ingwersen, T., Königsberg, A., et al. (2021) Preserved Structural Connectivity Mediates the Clinical Effect of Thrombo-lysis in Patients with Anterior-Circulation Stroke. Nature Communications, 12, 2590. [Google Scholar] [CrossRef] [PubMed]
[7] Ma, G., Pan, Z., Kong, L., et al. (2021) Neuroinflammation in Hemorrhagic Transformation after Tissue Plasminogen Activator Thrombolysis: Potential Mechanisms, Targets, Thera-peutic Drugs and Biomarkers. International Immunopharmacology, 90, Article ID: 107216. [Google Scholar] [CrossRef] [PubMed]
[8] Amantea, D., Nappi, G., Bernardi, G., et al. (2009) Post-Ischemic Brain Damage: Pathophysiology and Role of Inflammatory Mediators. FEBS Journal, 276, 13-26. [Google Scholar] [CrossRef] [PubMed]
[9] Kriz, J. (2006) Inflammation in Ischemic Brain Injury: Timing Is Important. Critical Reviews™ in Neurobiology, 18, 145-157. [Google Scholar] [CrossRef] 
[10] Engler-Chiurazzi, E.B., Monaghan, K.L., Wan, E., et al. (2020) Role of B Cells and the Aging Brain in Stroke Recovery and Treatment. Geroscience, 42, 1199-1216. [Google Scholar] [CrossRef] [PubMed]
[11] Seifert, H.A., Vandenbark, A.A. and Offner, H. (2018) Regula-tory B Cells in Experimental Stroke. Immunology, 154, 169-177. [Google Scholar] [CrossRef] [PubMed]
[12] Javidi, E. and Magnus, T. (2019) Autoimmunity after Ischemic Stroke and Brain Injury. Frontiers in Immunology, 10, Article No. 686. [Google Scholar] [CrossRef] [PubMed]
[13] Yilmaz, G., Arumugam, T.V., Stokes, K.Y., et al. (2006) Role of T Lymphocytes and Interferon-Gamma in Ischemic Stroke. Circulation, 113, 2105-2112. [Google Scholar] [CrossRef] 
[14] Liesz, A., Hu, X., Kleinschnitz, C., et al. (2015) Functional Role of Regulatory Lymphocytes in Stroke: Facts and Controversies. Stroke, 46, 1422-1430. [Google Scholar] [CrossRef] 
[15] Magge, R., Lau, B.C., Soares, B.P., et al. (2013) Clinical Risk Factors and CT Imaging Features of Carotid Atherosclerotic Plaques as Predictors of New Incident Carotid Ischem-ic Stroke: A Retrospective Cohort Study. AJNR American Journal of Neuroradiology, 34, 402-409. [Google Scholar] [CrossRef] 
[16] Gokaldas, R., Singh, M., Lal, S., et al. (2015) Carotid Stenosis: From Di-agnosis to Management, Where Do We Stand? Current Atherosclerosis Reports, 17, 480. [Google Scholar] [CrossRef] [PubMed]
[17] Freilinger, T., Dimitriadis, K., Nikolaou, K., et al. (2011) Stroke While Squeezing a Pimple: Traumatic Rupture of a Vulnerable Carotid Artery Plaque. Neurology, 76, 305-306. [Google Scholar] [CrossRef] 
[18] Li, X., Li, J., Wu, G. (2021) Relationship of Neutro-phil-to-Lymphocyte Ratio with Carotid Plaque Vulnerability and Occurrence of Vulnerable Carotid Plaque in Patients with Acute Ischemic Stroke. BioMed Research International, 2021, Article ID: 6894623. [Google Scholar] [CrossRef] [PubMed]
[19] Corriere, T., Di Marca, S., Cataudella, E., et al. (2018) Neutro-phil-to-Lymphocyte Ratio Is a Strong Predictor of Atherosclerotic Carotid Plaques in Older Adults. Nutrition, Metabo-lism & Cardiovascular Diseases, 28, 23-27. [Google Scholar] [CrossRef] [PubMed]
[20] Suh, B., Shin, D.W., Kwon, H.M., et al. (2017) Elevated Neu-trophil to Lymphocyte Ratio and Ischemic Stroke Risk in Generally Healthy Adults. PLoS ONE, 12, e0183706. [Google Scholar] [CrossRef] [PubMed]
[21] Huang, L.Y., Sun, F.R., Yin, J.J., et al. (2021) Associations of the Neutrophil to Lymphocyte Ratio with Intracranial Artery Stenosis and Ischemic Stroke. BMC Neurology, 21, 56. [Google Scholar] [CrossRef] [PubMed]
[22] Sun, G., Yang, Y., Chen, Z., et al. (2020) Neutrophil to Lym-phocyte Ratio Predicts Outcome of Stroke by Cervicocranial Arterial Dissection. Frontiers in Medicine (Lausanne), 7, Article ID: 598055. [Google Scholar] [CrossRef] [PubMed]
[23] Nam, K.W., Kim, T.J, Lee, J.S., et al. (2018) High Neutro-phil-to-Lymphocyte Ratio Predicts Stroke-Associated Pneumonia. Stroke, 49, 1886-1892. [Google Scholar] [CrossRef] 
[24] Zhang, R., Wu, X., Hu, W., et al. (2019) Neutro-phil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Ischemic Stroke: A Meta-Analysis. Brain and Be-havior, 9, e01382. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, C., Zhang, Q., Ji, M., et al. (2021) Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A Systematic Review and Meta-Analysis. BMC Neurology, 21, Article No. 191. [Google Scholar] [CrossRef] [PubMed]
[26] Han, D., Liu, H. and Gao, Y. (2020) The Role of Peripheral Monocytes and Macrophages in Ischemic Stroke. Neurological Sciences, 41, 3589-3607. [Google Scholar] [CrossRef] [PubMed]
[27] Che, X., Ye, W., Pang, L., et al. (2001) Monocyte Chemoat-tractant Protein-1 Expressed in Neurons and Astrocytes during Focal Ischemia in Mice. Brain Research, 902, 171-177. [Google Scholar] [CrossRef] 
[28] Chu, H.X., Arumugam, T.V., Gelderblom, M., et al. (2014) Role of CCR2 in Inflammatory Conditions of the Central Nervous System. Journal of Cerebral Blood Flow & Metabo-lism, 34, 1425-1429. [Google Scholar] [CrossRef] [PubMed]
[29] Dimitrijevic, O.B., Stamatovic, S.M., Keep, R.F., et al. (2007) Ab-sence of the Chemokine Receptor CCR2 Protects against Cerebral Ischemia/Reperfusion Injury in Mice. Stroke, 38, 1345-1353. [Google Scholar] [CrossRef] 
[30] Schilling, M., Strecker, J.K., Ringelstein, E.B., et al. (2009) The Role of CC Chemokine Receptor 2 on Microglia Activation and Blood-Borne Cell Recruitment after Transient Focal Cerebral Ischemia in Mice. Brain Research, 1289, 79-84. [Google Scholar] [CrossRef] [PubMed]
[31] Schuette-Nuetgen, K., Strecker, J.K., Minnerup, J., et al. (2012) MCP-1/CCR-2-Double-Deficiency Severely Impairs the Migration of Hematogenous Inflammatory Cells Following Transient Cerebral Ischemia in Mice. Experimental Neurology, 233, 849-858. [Google Scholar] [CrossRef] [PubMed]
[32] Gliem, M., Mausberg, A.K., Lee, J.I., et al. (2012) Macro-phages Prevent Hemorrhagic Infarct Transformation in Murine Stroke Models. Annals of Neurology, 71, 743-752. [Google Scholar] [CrossRef] [PubMed]
[33] Ajmo, C.T., Vernon, D.O., Collier, L., et al. (2008) The Spleen Contributes to Stroke-Induced Neurodegeneration. Journal of Neuroscience Research, 86, 2227-2234. [Google Scholar] [CrossRef] [PubMed]
[34] Ma, Y., Li, Y., Jiang, L., et al. (2016) Macrophage Depletion Reduced Brain Injury Following Middle Cerebral Artery Occlusion in Mice. Journal of Neuroinflammation, 13, 38. [Google Scholar] [CrossRef] [PubMed]
[35] Ostrowski, R.P., Schulte, R.W., Nie, Y., et al. (2012) Acute Splenic Irradiation Reduces Brain Injury in the Rat Focal Ischemic Stroke Model. Translational Stroke Research, 3, 473-481. [Google Scholar] [CrossRef] [PubMed]
[36] Fang, W., Zhai, X., Han, D., et al. (2018) CCR2-Dependent Monocytes/Macrophages Exacerbate Acute Brain Injury but Promote Functional Recovery after Is-chemic Stroke in Mice. Theranostics, 8, 3530-3543. [Google Scholar] [CrossRef] [PubMed]
[37] Pedragosa, J., Miró-Mur, F., Otxoa-de-Amezaga, A., et al. (2020) CCR2 Deficiency in Monocytes Impairs Angiogenesis and Functional Recovery after Ischemic Stroke in Mice. Journal of Cer-ebral Blood Flow & Metabolism, 40, S98-S116. [Google Scholar] [CrossRef] 
[38] Chu, H.X., Broughton, B.R., Kim, H.A., et al. (2015) Evidence That Ly6C(hi) Monocytes Are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization. Stroke, 46, 1929-1937. [Google Scholar] [CrossRef] 
[39] Wattananit, S., Tornero, D., Graubardt, N., et al. (2016) Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice. Journal of Neuroscience, 36, 4182-4195. [Google Scholar] [CrossRef] 
[40] Perego, C., Fumagalli, S., Zanier, E.R., et al. (2016) Macrophages Are Essential for Maintaining a M2 Protective Response Early after Ischemic Brain Injury. Neurobiology of Disease, 96, 284-293. [Google Scholar] [CrossRef] [PubMed]
[41] Werner, Y., Mass, E., Ashok Kumar, P., et al. (2020) Cxcr4 Dis-tinguishes HSC-Derived Monocytes from Microglia and Reveals Monocyte Immune Responses to Experimental Stroke. Nature Neuroscience, 23, 351-362. [Google Scholar] [CrossRef] [PubMed]
[42] Wang, R., Liu, Y., Ye, Q., et al. (2020) RNA Sequencing Reveals Novel Macrophage Transcriptome Favoring Neurovascular Plasticity after Ischemic Stroke. Journal of Cerebral Blood Flow & Metabolism, 40, 720-738. [Google Scholar] [CrossRef] 
[43] Cao, L. and He, C. (2013) Polarization of Macrophages and Mi-croglia in Inflammatory Demyelination. Neuroscience Bulletin, 29, 189-198. [Google Scholar] [CrossRef] [PubMed]
[44] Zuo, B., Zhu, S., Meng, X., et al. (2019) Monocyte/Lymphocyte Ratio Is Associated with Carotid Stenosis in Ischemic Stroke: A Retrospective Analysis. Brain and Behavior, 9, e01429. [Google Scholar] [CrossRef] [PubMed]
[45] Liu, H., Zhan, F. and Wang, Y. (2020) Evaluation of Mono-cyte-to-High-Density Lipoprotein Cholesterol Ratio and Monocyte-to-Lymphocyte Ratio in Ischemic Stroke. Journal of International Medical Research, 48, 1-12. [Google Scholar] [CrossRef] [PubMed]
[46] Ren, H., Liu, X., Wang, L., et al. (2017) Lympho-cyte-to-Monocyte Ratio: A Novel Predictor of the Prognosis of Acute Ischemic Stroke. Journal of Stroke and Cerebro-vascular Diseases, 26, 2595-2602. [Google Scholar] [CrossRef] [PubMed]
[47] Song, Q., Pan, R., Jin, Y., et al. (2020) Lympho-cyte-to-Monocyte Ratio and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. Neurological Sciences, 41, 2511-2520. [Google Scholar] [CrossRef] [PubMed]
[48] Cheng, H.R., Song, J.Y., Zhang, Y.N., et al. (2020) High Mon-ocyte-to-Lymphocyte Ratio Is Associated with Stroke-Associated Pneumonia. Frontiers in Neurology, 11, Article ID: 575809. [Google Scholar] [CrossRef] [PubMed]
[49] Cao, F., Wan, Y., Lei, C., et al. (2021) Monocyte-to-Lymphocyte Ratio as a Predictor of Stroke-Associated Pneumonia: A Retrospective Study-Based Investigation. Brain and Behavior, 11, e02141. [Google Scholar] [CrossRef] [PubMed]
[50] Chong, L., Han, L., Liu, R., et al. (2021) Association of Lym-phocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke. Medical Science Moni-tor, 27, e930076. [Google Scholar] [CrossRef] 
[51] Yeo, L.L., Paliwal, P., Teoh, H.L., et al. (2013) Early and Continuous Neurologic Improvements after Intravenous Thrombolysis Are Strong Predictors of Favorable Long-Term Outcomes in Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 22, e590-596. [Google Scholar] [CrossRef] [PubMed]
[52] Mori, M., Naganuma, M., Okada, Y., et al. (2012) Early Neurological Deterioration within 24 Hours after Intravenous rt-PA Therapy for Stroke Patients: The Stroke Acute Management with Urgent Risk Factor Assessment and Improvement rt-PA Registry. Cerebrovascular Diseases, 34, 140-146. [Google Scholar] [CrossRef] [PubMed]
[53] Gong, P., Liu, Y., Gong, Y., et al. (2021) The Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Lymphocyte to Monocyte Ratio with Post-Thrombolysis Early Neurological Outcomes in Patients with Acute Ischemic Stroke. Journal of Neuroinflammation, 18, 51. [Google Scholar] [CrossRef] [PubMed]
[54] Ren, H., Han, L., Liu, H., et al. (2017) Decreased Lym-phocyte-to-Monocyte Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Treated with Thrombolysis. Medical Sci-ence Monitor, 23, 5826-5833. [Google Scholar] [CrossRef] 
[55] Maners, J., Gill, D., Pankratz, N., et al. (2020) A Mendelian Random-ization of γ’ and Total Fibrinogen Levels in Relation to Venous Thromboembolism and Ischemic Stroke. Blood, 136, 3062-3069. [Google Scholar] [CrossRef] [PubMed]
[56] Akassoglou, K. and Strickland, S. (2002) Nervous System Pathol-ogy: The Fibrin Perspective. Biological Chemistry, 383, 37-45. [Google Scholar] [CrossRef] 
[57] Rudnicka, A.R., Mt-Isa, S. and Meade, T.W. (2006) Associations of Plasma Fibrinogen and Factor VII Clotting Activity with Coronary Heart Disease and Stroke: Prospective Cohort Study from the Screening Phase of the Thrombosis Prevention Trial. Journal of Thrombosis and Haemostasis, 4, 2405-2410. [Google Scholar] [CrossRef] [PubMed]
[58] Del Zoppo, G.J., Levy, D.E., Wasiewski, W.W., et al. (2009) Hyperfibrinogenemia and Functional Outcome from Acute Ischemic Stroke. Stroke, 40, 1687-1691. [Google Scholar] [CrossRef] 
[59] Di Napoli, M. and Singh, P. (2009) Is Plasma Fibrinogen Useful in Evaluating Ischemic Stroke Patients? Why, How, and When. Stroke, 40, 1549-1552. [Google Scholar] [CrossRef] 
[60] Wardlaw, J.M., Murray, V., Berge, E., et al. (2009) Thrombolysis for Acute Ischaemic Stroke. The Cochrane Database of Systematic Reviews, No. 4, CD000213. [Google Scholar] [CrossRef] 
[61] Han, H.S., Qiao, Y., Karabiyikoglu, M., et al. (2002) In-fluence of Mild Hypothermia on Inducible Nitric Oxide Synthase Expression and Reactive Nitrogen Production in Ex-perimental Stroke and Inflammation. Journal of Neuroscience, 22, 3921-3928. [Google Scholar] [CrossRef] 
[62] Iadecola, C., Zhang, F., Casey, R., et al. (1997) De-layed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene. Journal of Neuroscience, 17, 9157-9164. [Google Scholar] [CrossRef] 
[63] Ill-Raga, G., Palomer, E., Ramos-Fernández, E., et al. (2015) Fibrinogen Nitrotyrosination after Ischemic Stroke Impairs Thrombolysis and Promotes Neuronal Death. Bio-chimica et Biophysica Acta, 1852, 421-428. [Google Scholar] [CrossRef] [PubMed]
[64] Peluffo, G. and Radi, R. (2007) Biochemistry of Protein Tyro-sine Nitration in Cardiovascular Pathology. Cardiovascular Research, 75, 291-302. [Google Scholar] [CrossRef] [PubMed]
[65] Moon, G.J., Shin, D.H., Im, D.S., et al. (2011) Identification of Oxidized Serum Albumin in the Cerebrospinal Fluid of Ischaemic Stroke Patients. European Journal of Neurology, 18, 1151-1158.
[66] Dziedzic, T., Slowik, A. and Szczudlik, A. (2004) Serum Albumin Level as a Predictor of Ischemic Stroke Outcome. Stroke, 35, e156-158. [Google Scholar] [CrossRef] 
[67] Pawelczyk, M., Kaczorowska, B. and Baj, Z. (2020) Fibrinogen Concentrations in Ischaemic Stroke Patients with Metabolic Disorders. Neurologia i Neurochirurgia Polska, 54, 259-264. [Google Scholar] [CrossRef] 
[68] Kofoed, S.C., Wittrup, H.H., Sillesen, H., et al. (2003) Fibrinogen Predicts Ischaemic Stroke and Advanced Atherosclerosis But Not Echolucent, Rupture-Prone Carotid Plaques: The Copenhagen City Heart Study. European Heart Journal, 24, 567-576. [Google Scholar] [CrossRef] 
[69] Koenig, W. (2003) Fibrin(ogen) in Cardiovascular Disease: An Update. Thrombosis and Haemostasis, 89, 601-609. [Google Scholar] [CrossRef] 
[70] Di Napoli, M., Papa, F. and Bocola, V. (2001) Prognostic Influence of Increased C-Reactive Protein and Fibrinogen Levels in Ischemic Stroke. Stroke, 32, 133-138. [Google Scholar] [CrossRef] 
[71] Liang, O.V., Kochetov, A.G., Shamalov, N.A., et al. (2012) Fibrin-ogen Concentration in the Evaluation of Safety and Efficiency of Thrombolytic Therapy in Patients with Ischemic Stroke. Terapevticheskii Arkhiv, 84, 42-47.
[72] Luan, X., Cheng, H., Chen, Y., et al. (2020) High Levels of Plasma Fibrinogen and Prothrombin Time Are Related to Post-Stroke Emotional Impairment. Brain Research, 1748, Article ID: 147017. [Google Scholar] [CrossRef] [PubMed]
[73] Pedersen, A., Stanne, T.M., Redfors, P., et al. (2018) Fibrino-gen Concentrations Predict Long-Term Cognitive Outcome in Young Ischemic Stroke Patients. Research and Practice in Thrombosis and Haemostasis, 2, 339-346. [Google Scholar] [CrossRef] [PubMed]
[74] Shi, J., Shi, R., Qin, W., et al. (2020) Dynamic Changes in Fibrinogen and Prognosis of Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. Neurotoxicity Research, 38, 775-784. [Google Scholar] [CrossRef] [PubMed]
[75] Li, J., Imano, H., Yamagishi, K., et al. (2021) Serum Albumin and Risks of Stroke and Its Subtypes—The Circulatory Risk in Communities Study (CIRCS). Circulation Journal, 85, 385-392. [Google Scholar] [CrossRef] 
[76] Yang, X., Wang, L., Zheng, L., et al. (2020) Serum Albu-min as a Potential Predictor of Pneumonia after an Acute Ischemic Stroke. Current Neurovascular Research, 17, 385-393. [Google Scholar] [CrossRef] [PubMed]
[77] Yang, C., Zhang, J., Liu, C., et al. (2020) Comparison of the Risk Factors of Hemorrhagic Transformation between Large Artery Atherosclerosis Stroke and Cardioembolism after Intravenous Thrombolysis. Clinical Neurology and Neurosurgery, 196, Article ID: 106032. [Google Scholar] [CrossRef] [PubMed]
[78] Che, R., Huang, X., Zhao, W., et al. (2017) Low Serum Al-bumin Level as a Predictor of Hemorrhage Transformation after Intravenous Thrombolysis in Ischemic Stroke Patients. Scientific Reports, 7, Article No. 7776. [Google Scholar] [CrossRef] [PubMed]
[79] Zhou, H., Wang, A., Meng, X., et al. (2021) Low Serum Albu-min Levels Predict Poor Outcome in Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack. Stroke and Vascular Neurology, 6, 458-466. [Google Scholar] [CrossRef] [PubMed]
[80] Zhang, Q., Lei, Y.X., Wang, Q., et al. (2016) Serum Albumin Level Is Associated with the Recurrence of Acute Ischemic Stroke. American Journal of Emergency Medicine, 34, 1812-1816. [Google Scholar] [CrossRef] [PubMed]

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