代谢综合征与进展期结直肠腺瘤的相关性
Associations between Metabolic Syndrome and Advanced Colorectal Adenoma
DOI: 10.12677/ACM.2022.125575, PDF,   
作者: 石富文, 张雪群:浙江大学医学院附属第一医院消化内科,浙江 杭州
关键词: 代谢综合征代谢改变进展期腺瘤高危腺瘤Metabolic Syndrome Metabolic Changes Advanced Adenomas High-Risk Adenomas
摘要: 结直肠癌(colorectal cancer, CRC)是全球第三大常见癌症,也是癌症死亡的第二大常见原因,其中约70%~90%由“传统腺瘤–癌”途径发展而来。进展期结直肠腺瘤(Advanced colorectal adenomas)被认为是具有高度恶性转化可能性的结直肠癌癌前病变。近年来大量研究证明了代谢综合征(metabolic syndrome, MS)与CRC的正相关性,然而代谢综合征及其组分与进展期结直肠腺瘤的关系研究仍较少,本文将对此进行综述。
Abstract: Colorectal cancer (colorectal cancer, CRC) is the third most common cancer worldwide and the sec-ond most common cause of cancer death. The traditional adenoma-carcinoma pathway leads to 70%~90% of colorectal cancers. Advanced colorectal adenomas are generally regarded as adeno-mas with a high tendency of malignant transformation. Recent years, numerous studies have con-firmed a positive association between metabolic syndrome and CRC. However, there are still few studies investigated the associations between metabolic syndrome and its components and ad-vanced colorectal adenoma. This article will review this issue.
文章引用:石富文, 张雪群. 代谢综合征与进展期结直肠腺瘤的相关性[J]. 临床医学进展, 2022, 12(5): 3964-3971. https://doi.org/10.12677/ACM.2022.125575

参考文献

[1] Gupta, S., Lieberman, D., Anderson, J.C., et al. (2020) Recommendations for Follow-Up after Colonoscopy and Poly-pectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. The American Journal of Gastroenterology, 115, 415-434. [Google Scholar] [CrossRef] [PubMed]
[2] Alberti, K.G., Zimmet, P. and Shaw, J. (2006) Metabolic Syndrome—A New World-Wide Definition. A Consensus Statement from the Interna-tional Diabetes Federation. Diabetic Medicine, 23, 469-480. [Google Scholar] [CrossRef] [PubMed]
[3] Lu, J., Wang, L., Li, M., et al. (2017) Metabolic Syndrome among Adults in China: The 2010 China Noncommunicable Disease Surveillance. The Journal of Clinical Endocrinology and Metabolism, 102, 507-515.
[4] Hong, W., Dong, L., Stock, S., et al. (2018) Prevalence and Characteristics of Co-lonic Adenoma in Mainland China. Cancer Management and Research, 10, 2743-2755. [Google Scholar] [CrossRef
[5] Chen, H.D., Li, N., Ren, J.S., et al. (2019) Participation and Yield of a Population-Based Colorectal Cancer Screening Programme in China. Gut, 68, 1450-1457. [Google Scholar] [CrossRef] [PubMed]
[6] Esposito, K., Chiodini, P., Colao, A., Lenzi, A. and Giugliano, D. (2012) Metabolic Syndrome and Risk of Cancer: A Systematic Review and Meta-Analysis. Diabetes Care, 35, 2402-2411. [Google Scholar] [CrossRef] [PubMed]
[7] Chen, H.Y., Zheng, X.B., Zong, X.Y., et al. (2021) Metabolic Syndrome, Metabolic Comorbid Conditions and Risk of Early-Onset Colorectal Cancer. Gut, 70, 1147-1154. [Google Scholar] [CrossRef] [PubMed]
[8] Tal, S., Melzer, E., Chsherbakov, T. and Malnick, S. (2014) Metabolic Syndrome Is Associated with Increased Prevalence of Advanced Colorectal Polyps. The Journal of Nutrition, Health & Aging, 18, 22-25. [Google Scholar] [CrossRef] [PubMed]
[9] Rampal, S., Yang, M.H., Sung, J., et al. (2014) Association be-tween Markers of Glucose Metabolism and Risk of Colorectal Adenoma. Gastroenterology, 147, 78-87.E3. [Google Scholar] [CrossRef] [PubMed]
[10] Kim, J.H., Lim, Y.J., Kim, Y.H., et al. (2007) Is Metabolic Syn-drome a Risk Factor for Colorectal Adenoma? Cancer Epidemiology, Biomarkers & Prevention, 16, 1543-1546. [Google Scholar] [CrossRef
[11] Kim, B.C., Shin, A., Hong, C.W., et al. (2012) Association of Colorectal Adenoma with Components of Metabolic Syndrome. Cancer Causes & Control, 23, 727-735. [Google Scholar] [CrossRef] [PubMed]
[12] Lee, S.E., Jo, H.B., Kwack, W.G., et al. (2016) Characteristics of and Risk Factors for Colorectal Neoplasms in Young Adults in a Screening Population. World Journal of Gastroenter-ology, 22, 2981-2992. [Google Scholar] [CrossRef] [PubMed]
[13] Chiu, H.M., Lee, Y.C., Tu, C.H., et al. (2015) Effects of Metabolic Syndrome and Findings from Baseline Colonoscopies on Occurrence of Colorectal Neoplasms. Clinical Gastroenterolo-gy and Hepatology, 13, 1134-1142.E8. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, M.C., Jung, S.W., Kim, C.S., et al. (2012) Metabolic Syn-drome Is Associated with Increased Risk of Recurrent Colorectal Adenomas in Korean Men. International Journal of Obesity, 36, 1007-1011. [Google Scholar] [CrossRef] [PubMed]
[15] Yao, F., et al. (2021) Prevalence and Influencing Factors of Metabolic Syndrome among Adults in China from 2015 to 2017. Nutrients, 13, No. 12.
[16] Alberti, K.G., Eckel, R.H., Grundy, S.M., et al. (2009) Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federa-tion Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Associa-tion; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obe-sity. Circulation, 120, 1640-1645. [Google Scholar] [CrossRef
[17] Bardou, M., Barkun, A.N. and Martel, M. (2013) Obesity and Colorectal Cancer. Gut, 62, 933-947. [Google Scholar] [CrossRef] [PubMed]
[18] Olefsky, J.M. and Glass, C.K. (2010) Macrophages, Inflamma-tion, and Insulin Resistance. Annual Review of Physiology, 72, 219-246. [Google Scholar] [CrossRef] [PubMed]
[19] Zafar, U., Khaliq, S., Ahmad, H.U., et al. (2018) Metabolic Syndrome: An Update on Diagnostic Criteria, Pathogenesis, and Genetic Links. Hormones, 17, 299-313. [Google Scholar] [CrossRef] [PubMed]
[20] Chung, Y.W., Han, D.S., Park, Y.K., et al. (2006) Association of Obesity, Serum Glucose and Lipids with the Risk of Advanced Colorectal Adenoma and Cancer: A Case-Control Study in Korea. Digestive and Liver Disease, 38, 668-672. [Google Scholar] [CrossRef] [PubMed]
[21] Dore, M.P., Longo, N.P., Manca, A. and Pes, G.M. (2020) The Impact of Body Weight on Dysplasia of Colonic Adenomas: A Case-Control Study. Scandinavian Journal of Gastroen-terology, 55, 460-465. [Google Scholar] [CrossRef] [PubMed]
[22] Waldmann, E., Heinze, G., Ferlitsch, A., et al. (2016) Risk Factors Cannot Explain the Higher Prevalence Rates of Precancerous Colorectal Lesions in Men. British Journal of Can-cer, 115, 1421-1429. [Google Scholar] [CrossRef] [PubMed]
[23] Jung, Y.S., Park, J.H., Park, D.I., et al. (2016) Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence. Digestive Diseases and Sciences, 61, 2694-2703. [Google Scholar] [CrossRef] [PubMed]
[24] Stegeman, I., de Wijkerslooth, T.R., Stoop, E.M., et al. (2013) Colorectal Cancer Risk Factors in the Detection of Advanced Adenoma and Colorectal Cancer. Cancer Epidemiology, 37, 278-283. [Google Scholar] [CrossRef] [PubMed]
[25] Nakai, K., Watari, J., Tozawa, K., et al. (2018) Sex Differences in Associations among Metabolic Syndrome, Obesity, Related Biomarkers, and Colorectal Adenomatous Polyp Risk in a Japanese Population. Journal of Clinical Biochemistry and Nutrition, 63, 154-163.
[26] Kasprzak, A. (2021) Insu-lin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer. International Journal of Mo-lecular Sciences, 22, Article No. 6434. [Google Scholar] [CrossRef] [PubMed]
[27] Yoon, Y.S., Keum, N., Zhang, X., et al. (2015) Hyperinsulinemia, Insulin Resistance and Colorectal Adenomas: A Meta-Analysis. Metabolism, 64, 1324-1333. [Google Scholar] [CrossRef] [PubMed]
[28] Cornier, M.A., Dabelea, D., Hernandez, T.L., et al. (2008) The Metabolic Syndrome. Endocrine Reviews, 29, 777-822. [Google Scholar] [CrossRef] [PubMed]
[29] Grunt, T.W. (2018) Interacting Cancer Machineries: Cell Signaling, Li-pid Metabolism, and Epigenetics. Trends in Endocrinology & Metabolism, 29, 86-98. [Google Scholar] [CrossRef] [PubMed]
[30] Kim, M., Vogtmann, E., Ahlquist, D.A., et al. (2020) Fecal Metab-olomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis. mBio, 11, e03186-19. [Google Scholar] [CrossRef
[31] Cubiella, J., Clos-Garcia, M., Alonso, C., et al. (2018) Targeted UPLC-MS Metabolic Analysis of Human Faeces Reveals Novel Low-Invasive Candidate Markers for Colorectal Cancer. Cancers, 10, Article No. 300. [Google Scholar] [CrossRef] [PubMed]
[32] Coppola, J.A., Shrubsole, M.J., Cai, Q., et al. (2015) Plasma Lipid Levels and Colorectal Adenoma Risk. Cancer Causes & Control, 26, 635-643. [Google Scholar] [CrossRef] [PubMed]
[33] Yang, M.H., Rampal, S., Sung, J., et al. (2013) The Association of Serum Lipids with Colorectal Adenomas. American Journal of Gastroenterology, 108, 833-841. [Google Scholar] [CrossRef] [PubMed]
[34] Esteve, E., Ricart, W. and Fernández-Real, J.M. (2005) Dyslipidemia and Inflammation: An Evolutionary Conserved Mechanism. Clinical Nutrition, 24, 16-31. [Google Scholar] [CrossRef] [PubMed]
[35] Kim, S., Keku, T.O., Martin, C., et al. (2008) Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas. Cancer Research, 68, 323-328. [Google Scholar] [CrossRef
[36] van Exel, E., Gussekloo, J., de Craen, A.J.M., et al. (2002) Low Production Capacity of Interleukin-10 Associates with the Metabolic Syndrome and Type 2 Diabetes : The Leiden 85-Plus Study. Diabetes, 51, 1088-1092. [Google Scholar] [CrossRef] [PubMed]
[37] Avramoglu, R.K., Basciano, H. and Adeli, K. (2006) Lipid and Lipoprotein Dysregulation in Insulin Resistant States. Clinica Chimica Acta, 368, 1-19. [Google Scholar] [CrossRef] [PubMed]
[38] Kontush, A., de Faria, E.C., Chantepie, S. and Chapman, J. (2005) A Normotriglyceridemic, Low HDL-Cholesterol Phenotype Is Characterised by Elevated Oxidative Stress and HDL Par-ticles with Attenuated Antioxidative Activity. Atherosclerosis, 182, 277-285. [Google Scholar] [CrossRef] [PubMed]
[39] Napoli, C., de Nigris, F. and Palinski, W. (2001) Multi-ple Role of Reactive Oxygen Species in the Arterial Wall. Journal of Cellular Biochemistry, 82, 674-682. [Google Scholar] [CrossRef] [PubMed]
[40] Esposito, K., Chiodini, P., Capuano, A., et al. (2013) Colorectal Cancer As-sociation with Metabolic Syndrome and Its Components: A Systematic Review with Meta-Analysis. Endocrine, 44, 634-647. [Google Scholar] [CrossRef] [PubMed]
[41] Wu, H., Zhang, J. and Zhou, B. (2021) Metabolic Syndrome and Colorectal Adenoma Risk: A Systematic Review and Meta-Analysis. Clinics and Research in Hepatology and Gastro-enterology, 45, Article ID: 101749. [Google Scholar] [CrossRef] [PubMed]
[42] Fliss-Isakov, N., Zelber-Sagi, S., Webb, M., et al. (2017) Dis-tinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps. Obesity, 25, S72-S80. [Google Scholar] [CrossRef] [PubMed]
[43] Park, J., Han, J.S., Jo, H.J., et al. (2021) Resting Heart Rate Is Associated with Colorectal Advanced Adenoma. PLoS ONE, 16, e0254505. [Google Scholar] [CrossRef] [PubMed]
[44] Ager, E.I., Neo, J. and Christophi, C. (2008) The Ren-in-Angiotensin System and Malignancy. Carcinogenesis, 29, 1675-1684. [Google Scholar] [CrossRef] [PubMed]
[45] Kochi, T., Shimizu, M., Ohno, T., et al. (2013) Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats. International Journal of Molecular Sci-ences, 14, 14700-14711. [Google Scholar] [CrossRef] [PubMed]
[46] Sandhu, M.S., Dunger, D.B. and Giovannucci, E.L. (2002) Insulin, Insulin-Like Growth Factor-I (IGF-I), IGF Binding Proteins, Their Biologic Interactions, and Colorectal Cancer. JNCI: Journal of the National Cancer Institute, 94, 972-980. [Google Scholar] [CrossRef] [PubMed]
[47] Liu, C.S., Hsu, H.S., Li, C.I., et al. (2010) Central Obesity and Ather-ogenic Dyslipidemia in Metabolic Syndrome Are Associated with Increased Risk for Colorectal Adenoma in a Chinese Population. BMC Gastroenterology, 10, Article No. 51. [Google Scholar] [CrossRef
[48] Reaven, G.M. (1988) Banting Lecture 1988. Role of Insulin Resistance in Human Disease. Diabetes, 37, 1595-1607. [Google Scholar] [CrossRef] [PubMed]
[49] DeFronzo, R.A. and Ferrannini, E. (1991) Insulin Resistance. A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovas-cular Disease. Diabetes Care, 14, 173-194. [Google Scholar] [CrossRef] [PubMed]
[50] Haffner, S.M., Valdez, R.A., Hazuda, H.P., et al. (1992) Prospective Analysis of the Insulin-Resistance Syndrome (Syndrome X). Diabetes, 41, 715-722. [Google Scholar] [CrossRef] [PubMed]