静脉溶栓治疗急性脑梗死与术后血压管理和预后的相关性研究进展
Intravenous Thrombolysis Treatment of Acute Cerebral Infarction and Postoperative Blood Pressure Management and Prognosis of the Correlation Research Progress
DOI: 10.12677/ACM.2022.125606, PDF,   
作者: 王 越*, 薛艺东#:延安大学附属医院,陕西 延安
关键词: 急性脑梗死溶栓血压预后Acute Cerebral Infarction Thrombolysis Blood Pressure The Prognosis
摘要: 急性缺血性脑卒中是神经内科最常见的疾病之一,静脉溶栓是目前国内外指南推荐的改善急性脑梗死(AIS)结局最有效的药物治疗手段。关于AIS患者溶栓急性期血压的降压方式,目前指南并没有明确的指向性,只指出了允许的最高血压。通过分析国内外多篇关于溶栓急性期是否需要强化降压治疗的文献,神经内科医生可以对患者的出血风险及预后进行初步评估,具有一定的指导意义。
Abstract: Acute ischemic stroke is one of the most common diseases in the department of neurology. Intra-venous thrombolysis is the most effective drug therapy recommended by domestic and foreign guidelines to improve the outcome of AIS. As for the way to reduce blood pressure in the acute stage of thrombolysis in patients with AIS, the current guidelines do not have clear directivity, but only indicate the maximum allowable blood pressure. By analyzing many domestic and foreign litera-tures on the need for intensive antihypertensive therapy in the acute stage of thrombolysis, neu-rologists can preliminarily evaluate the bleeding risk and prognosis of patients, which has certain guiding significance.
文章引用:王越, 薛艺东. 静脉溶栓治疗急性脑梗死与术后血压管理和预后的相关性研究进展[J]. 临床医学进展, 2022, 12(5): 4181-4186. https://doi.org/10.12677/ACM.2022.125606

参考文献

[1] Pan, Y.M. and Shi, G.W. (2021) Silver Jubilee of Stroke Thrombolysis with Alteplase: Evolution of the Therapeutic Window. Frontiers in Neurology, 12, Article ID: 593887. [Google Scholar] [CrossRef] [PubMed]
[2] Zhou, Z.E., Delcourt, C., Xia, C., et al. (2021) Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial. Neurology, 96, e1512-e1526. [Google Scholar] [CrossRef
[3] Psychogios, K., Palaiodimou, L., Katsanos, A.H., et al. (2021) Real-World Comparative Safety and Efficacy of Tenecteplase versus Alteplase in Acute Ischemic Stroke Patients with Large Vessel Occlusion. Therapeutic Advances in Neurological Disorders, 14. [Google Scholar] [CrossRef] [PubMed]
[4] Acherqui, M., Khattab, H., Habtany, Y., et al. (2020) Assessment of Eligibility for Thrombolysis in Acute Ischaemic Stroke Patients in Morocco. The Pan African Medical Journal, 36, Article No. 351. [Google Scholar] [CrossRef] [PubMed]
[5] Chew, S.H., Looi, I., Neoh, K.K., et al. (2021) Clinical Outcomes of Acute Stroke Thrombolysis in Neurologist and Non-Neurologist Centres—A Comparative Study in Malay-sia. Medical Journal of Malaysia, 76, 12-16.
[6] Sun, L.L., Song, L.L., Yang, J., et al. (2021) Smoking Influences Outcome in Patients Who Had Thrombolysed Ischaemic Stroke: The ENCHANTED Study. Stroke and Vascular Neu-rology, 6, 395-401. [Google Scholar] [CrossRef] [PubMed]
[7] Sun, Z.J., Feng, J.Y., He, M.L., et al. (2020) Higher Uric Acid Is Associated with Better Discharge Recovery and Short-Term Outcome in Stroke Patients Treated with Thrombolysis. Neurological Sciences, 42, 3225-3231. [Google Scholar] [CrossRef] [PubMed]
[8] Kim, B.-G., Kim, G.Y. and Cha, J.-K. (2021) Pre-Diabetes Is a Predictor of Short-Term Poor Outcomes after Acute Ischemic Stroke Using IV Thrombolysis. BMC Neurology, 21, Arti-cle No. 72. [Google Scholar] [CrossRef] [PubMed]
[9] 吴连爽, 唐茜, 王本玄, 尹昌浩. 缺血性脑卒中静脉溶栓出血转化风险预测的研究进展[J]. 中国实用神经疾病杂志, 2020, 23(19): 1744-1748.
[10] Flint, A.C., Faigeles, B.S., Cullen, S.P., Kamel, H., Rao, V.A., Gupta, R., et al. (2013) THRIVE Score Predicts Ischemic Stroke Outcomes and Thrombolytic Hemorrhage Risk in VISTA. Stroke, 44, 3365-3369. [Google Scholar] [CrossRef
[11] Wu, Y.Y., Chen, H., Liu, X.Y., et al. (2020) A New Nomogram for Individualized Prediction of the Probability of Hemorrhagic Transformation after Intravenous Thrombo-lysis for Ischemic Stroke Patients. BMC Neurology, 20, Article No. 426. [Google Scholar] [CrossRef] [PubMed]
[12] 彭斌, 吴波. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682.
[13] Mowla, A., Memon, A., Razavi, S.-M., et al. (2021) Safety of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Taking Warfarinwith Subtherapeutic INR. Journal of Stroke and Cerebrovascular Diseases, 30, Article ID: 105678. [Google Scholar] [CrossRef] [PubMed]
[14] Yang, W.-Y., Li, Y.-F., Wang, Z.-R., et al. (2021) Combined Therapy of Intensive Statin plus Intravenous rt-PA in Acute Ischemic Stroke: The INSPIRE Randomized Clinical Trial. Journal of Neurology, 268, 2560-2569. [Google Scholar] [CrossRef] [PubMed]
[15] Qin, J.C. and Zhang, Z.J. (2020) Prognostic Significance of Early Systolic Blood Pressure Variability after Endovascular Thrombectomy and Intravenous Thrombolysis in Acute Is-chemic Stroke: A Systematic Review and Meta-Analysis. Brain and Behavior, 10, e01898. [Google Scholar] [CrossRef] [PubMed]
[16] Tomii, Y., Toyoda, K., Nakashima, T., et al. (2011) Effects of Hyperacute Blood Pressure and Heart Rate on Stroke Outcomes after Intravenous Tissue Plasminogen Activator. Journal of Hyper-tension, 29, 1980-1987. [Google Scholar] [CrossRef
[17] Endo, K., Kario, K., Koga, M., et al. (2013) Impact of Early Blood Pressure Variability on Stroke Outcomes after Thrombolysis: The SAMURAI rt-PA Registry. Stroke, 44, 816-818. [Google Scholar] [CrossRef
[18] Berge, E., Cohen, G., Lindley, R.I., et al. (2015) Effects of Blood Pressure and Blood Pressure-Lowering Treatment during the First 24 Hours among Patients in the Third Inter-national Stroke Trial of Thrombolytic Treatment for Acute Ischemic Stroke. Stroke, 46, 3362-3369. [Google Scholar] [CrossRef
[19] Huang, Y.N., Sharma, V.K., Robinson, T., et al. (2015) Rationale, Design, and Progress of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (Enchanted) Trial: An International Multicenter 2× 2 Quasi-Factorial Randomized Controlled Trial of Low- vs. Standard-Dose rt-PA and Early Intensive vs. Guideline-Recommended Blood Pressure Lowering in Patients with Acute Ischaemic Stroke Eli-gible for Thrombolysis Treatment. International Journal of Stroke, 10, 778-788. [Google Scholar] [CrossRef] [PubMed]
[20] Li, C., Wang, Y., Chen, Y., et al. (2015) Optimal Blood Pressure Levels in Patients Undergoing Intravenous Thrombolysis for AIS. Minerva Medica, 106, 255-258.
[21] Gill, D., Cox, T., Aravind, A., et al. (2016) A Fall in Systolic Blood Pressure 24 Hours after Thrombolysis for Acute Ischemic Stroke Is Associated with Early Neurological Recovery. Journal of Stroke and Cerebrovascular Diseases, 25, 1539-1543. [Google Scholar] [CrossRef] [PubMed]
[22] Zhou, Z.E., Xia, C., Carcel, C., et al. (2021) Inten-sive versus Guideline-Recommended Blood Pressure Reduction in Acute Lacunar Stroke with Intravenous Thrombolysis Therapy: The ENCHANTED Trial. European Journal of Neurology, 28, 783-793. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, X., Song, L.L., Yang, J., et al. (2019) Interaction of Blood Pressure Lowering and Alteplase Dose in Acute Ischemic Stroke: Results of the Enhanced Control of Hypertension and Throm-bolysis Stroke Study. Cerebrovascular Diseases, 48, 207-216. [Google Scholar] [CrossRef] [PubMed]
[24] Darger, B., Gonzales, N., Banuelos, R.C., et al. (2015) Outcomes of Patients Requiring Blood Pressure Control before Thrombolysis with tPA for Acute Ischemic Stroke. The Western Journal of Emergency Medicine, 16, 1002-1006. [Google Scholar] [CrossRef] [PubMed]