3D打印微孔聚醚醚酮/纳米羟基磷灰石生物材料颅脑修复
3D Printed Microporous PEEK/Nano-Hydroxyapatite Biomaterials for Brain Repair
DOI: 10.12677/ACM.2022.125630, PDF,    科研立项经费支持
作者: 陈 程, 王世达, 李欣松, 程丽佳*, 刘师巧, 王 婷：成都大学基础医学院，四川 成都
关键词: 3D打印；聚醚醚酮；纳米羟基磷灰石；颅脑修复；3D Printing； PEEK； Nano-Hydroxyapatite； Cerebral Repair
摘要: 目的：为了探索3D打印微孔聚醚醚酮/纳米羟基磷灰石生物材料颅脑修复的功能。方法：基于3D金属打印技术结合聚醚醚酮材料制备构建具有微孔结构聚醚醚酮，通过悬浮涂层和熔融结合技术在微孔聚醚醚酮表面制备出具有生物活性的纳米羟基磷灰石(nano-hydroxyapatite)生物陶瓷涂层，并植入7例患者颅骨缺损处，根据术后影像学来分析颅骨的修复情况。结果：制造出骨骼内部的微仿生结构，孔隙支持细胞穿过和代谢物流通，并为种植细胞提供优良的微环境，以利于其的黏附、增殖及分化。结论：3D打印微孔聚醚醚酮/纳米羟基磷灰石生物材料能做到更好的颅脑修复。
Abstract: Objective: To explore the function of 3D printed microporous polyetheretherketone (PEEK)/nano- hydroxyapatite (nHA) biomaterials for brain repair. Methods: PEEK with microporous structure was prepared based on 3D metal printing technology and PEEK material. nHA bioceramics coating with biological activity was prepared on the surface of microporous polyether ether by suspension coat-ing and melting bonding technology, and implanted it into the 7 patients skull defect, according to the postoperative imaging to analyze the skull repair. Results: The microbiomimetic structure in-side the bone is produced. The pores support the passage of cells and the circulation of metabolites, and provide an excellent micro environment for the adhesion, proliferation and differentiation of the implanted cells. Conclusion: 3D printed microporous PEEK/nHA biomaterials can achieve better cranial repair.
文章引用：陈程, 王世达, 李欣松, 程丽佳, 刘师巧, 王婷. 3D打印微孔聚醚醚酮/纳米羟基磷灰石生物材料颅脑修复[J]. 临床医学进展, 2022, 12(5): 4349-4354. https://doi.org/10.12677/ACM.2022.125630

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