CO₂点阵激光联合他克莫司治疗白癜风的疗效与安全性Meta分析

Meta-Analysis on the Efficacy and Safety of CO₂ Fractional Laser Combined with Tacrolimus in the Treatment of Vitiligo

摘要: 目的：系统评价CO₂点阵激光联合他克莫司治疗白癜风的疗效和安全性。方法：在Cochrane Library、PubMed、Embase、CNKI、VIP、Wanfang data、CBM检索，得到CO₂点阵激光联合他克莫司治疗白癜风相关文献，按制定标准筛选后，用Revman5.3软件分析。结果：共9篇随机对照试验，含694例白癜风患者，以有效率为疗效指标。Meta分析结果为RR = 1.30，95% CI (1.21, 1.40)，Z = 7.17，P < 0.00001，表示CO₂点阵激光联合他克莫司治疗白癜风的有效率高于单用他克莫司；不良反应发生率无明显差异。结论：CO₂点阵激光联合他克莫司与单用他克莫司相比治疗白癜风效果更好，且安全性佳，无显著不良反应。

Abstract: Objective: To systematically evaluate the efficacy and safety of CO₂ fractional laser combined with tacrolimus in the treatment of vitiligo. Methods: Literature related to the treatment of vitiligo with CO₂ fractional laser combined with tacrolimus were retrieved from Cochrane Library, PubMed, Em-base, CNKI, VIP, Wanfang data and CBM. After screening according to the established standards, Revman5.3 software was used for analysis. Results: There were 9 randomized controlled trials in-volving 694 patients with vitiligo. The effective rate was taken as the curative effect index. The re-sults of meta-analysis were RR = 1.30, 95% CI (1.21, 1.40), Z = 7.17, P < 0.00001, indicating that CO₂ fractional laser combined with tacrolimus was more effective than tacrolimus alone in the treat-ment of vitiligo. There was no significant difference in the incidence of adverse reactions. Conclu-sion: CO₂ fractional laser combined with tacrolimus has better efficacy and safety than tacrolimus alone in the treatment of vitiligo, with no significant adverse reactions.