Claudin18.2及MMP9在胃癌中的研究进展
Research Progress of Claudin18.2 and MMP9 in Gastric Cancer
DOI: 10.12677/ACM.2022.125681, PDF,    科研立项经费支持
作者: 王雪纯, 王丰梅*, 郑小影：青海大学附属医院病理科，青海 西宁
关键词: Claudin18.2蛋白；MMP9蛋白；表达；胃癌；Claudin18.2 Protein； MMP9 Protein； Expression； Gastric Cancer
摘要: Claudin18.2蛋白在多种肿瘤中均可表达，当胃粘膜上皮组织发生恶性转换时，细胞极性的紊乱将导致细胞表面的claudin18.2蛋白表位暴露，使其成为胃癌治疗的潜在靶点。MMP9能够破坏、降解细胞外机制中的组成成分，进而破坏细胞基底膜的完整性，在肿瘤中的浸润、转移中起重要作用。本综述通过阅读大量文献，简要阐述了claudin18.2蛋白和MMP9蛋白，并描述了claudin18.2及MMP9蛋白在胃癌中的表达情况及其与胃癌靶向药物治疗的关系。
Abstract: Claudin18.2 protein can be expressed in a variety of tumors, and when the gastric mucosal epitheli-al tissue undergoes malignant transition, the disorder of cell polarity will lead to the exposure of the claudin18.2 protein epitope on the cell surface, making it a potential target for gastric cancer treatment. MMP9 can destroy and degrade the components of the extracellular mechanism, thereby destroying the integrity of the cell basement membrane, and plays an important role in the inva-sion and metastasis of tumors. By reading a large number of literature, this review briefly expounds the claudin18.2 protein and MMP9 protein, and describes the expression of claudin18.2 and MMP9 protein in gastric cancer and its relationship with targeted drug therapy for gastric cancer.
文章引用：王雪纯, 王丰梅, 郑小影. Claudin18.2及MMP9在胃癌中的研究进展[J]. 临床医学进展, 2022, 12(5): 4705-4710. https://doi.org/10.12677/ACM.2022.125681

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