Pin1和P16在肺鳞癌中的表达及临床意义

Expression and Clinical Significance of Pin1 and P16 in Lung Squamous Carcinoma

摘要: P16作为细胞周期的一种调节性蛋白，能够直接参与细胞的周期与调控，阻止细胞周期的转换，起到了负性调节细胞的增殖与分裂的作用。Pin1是人类高度保守的特异性磷酸化肽基脯氨酰顺及异构酶，它作用于脯氨酸所形成的肽键，并且仅使磷酸化pSer/Thr-Pro发生异构化，这一磷酸化后调控机制能诱导磷酸蛋白的构像变化，使其发挥功能。Pin1在包括非小细胞肺癌在内的许多不同肿瘤中过表达，可能被用作肿瘤标志物或作为肿瘤治疗的靶点、Pin1抑制剂在胰腺癌、肺癌的治疗中可以起到化疗增效或免疫增效的作用，Pin1促进肿瘤进展的相关机制与P16抑制细胞增殖成为肿瘤防治的重要研究领域。本文主要就Pin1与P16结构与功能进行简单介绍，探讨其与肺鳞癌患者各种临床病理特征的可能关系，以期为肺鳞癌的发生发展和治疗方法提供有利的依据，为癌症患者带来了新的希望。

Abstract: As a regulatory protein of the cell cycle, P16 can directly participate in the cell cycle and regulation, prevent the cell cycle conversion, and play a role in negatively regulating cell proliferation and divi-sion. Pin1 is a highly conserved human phosphorylated peptidyl prolyl cis and isomerase, which acts on the peptide bonds formed by proline and only isomerizes phosphorylated pSer/Thr- Pro. This post-phosphorylation regulatory mechanism can induce conformational changes in phospho-proteins to function. Pin1 overexpression in many different tumors, including non-small cell lung cancer, may be used as tumor markers or as a target for tumor therapy. Pin1 inhibitors in the treatment of pancreatic cancer, lung cancer, can play the role of chemotherapy efficiency or immune efficiency. Pin1 promotes tumor progression mechanism and P16 inhibits cell proliferation, which become an important research area of tumor prevention and treatment. This paper mainly makes a brief introduction to the structure and function of Pin1 and P16, and discusses its possible rela-tionship with various clinicopathological features of lung squamous cell carcinoma patients, so as to provide a favorable basis for the development and treatment of lung squamous cell carcinoma, and bring new hope for cancer patients.