脑小血管病影像学总负荷与血浆生物标志物的相关性研究
Correlation between Imaging Total Load and Plasma Biomarkers in Patients with Small Vascular Disease
摘要: 脑小血管病(Cerebral small vessel disease, CSVD)是目前研究领域的热门话题，CSVD的发病机制尚不清楚，尚有众多危险因素未被研究所证实，近年来，CSVD的检出率和发病率有所提高，检测特定的CSVD生物标志物已成为临床诊治中的一个重要课题。本文从碱性磷酸酶(Alkaline phosphatase, ALP)、胱抑素C (Cystatin C, CysC)、肌酐(Creatinine, Cr)等3个方面，将对ALP、CysC、Cr与CSVD影像学总负荷的相关性做一综述，寻找相对灵敏的早期诊断指标，从而达到更好的防控效果。
Abstract: Cerebral small vessel disease (CVSD) is a hot topic in the current research field. The pathogenesis of CSVD is still unclear, and many risk factors have not been confirmed by research. In recent years, the detection rate and incidence rate of CSVD have increased, and the detection of specific CSVD biomarkers has become an important topic in clinical diagnosis and treatment. This paper reviews the correlation between ALP, Cr, CysC and the total imaging load of CSVD from three aspects: alka-line phosphatase (ALP), cystatin C (CysC) and creatinine (Cr), to find relatively sensitive early diag-nostic indexes, so as to achieve better prevention and control effect.
文章引用：靳桢, 冶学兰. 脑小血管病影像学总负荷与血浆生物标志物的相关性研究[J]. 临床医学进展, 2022, 12(6): 5294-5298. https://doi.org/10.12677/ACM.2022.126767

参考文献

[1] 唐若楠, 邢晓娜, 陈晓虹. 脑小血管病影像学标志物总负荷评估及其应用[J]. 中华神经科杂志, 2019, 52(2): 136-142.
[2] Leeuw, F.E., Groot, J.C., Achten, E., et al. (2001) Prevalence of Cerebral White Matter Lesions in El-derly People: A Population Based Magnetic Resonance Imaging Study. The Sotterdam Scan Study. Journal of Neurology, Neurosurgery and Psychiatry, 70, 9-14. [Google Scholar] [CrossRef] [PubMed]
[3] 张长青. 脑小血管病的危险因素、影像特征及预后研究[D]: [博士学位论文]. 北京: 首都医科大学, 2015.
[4] 侯小顺, 朱东亚. 脑小血管病及其相关的认知功能障碍研究进展[J]. 南京医科大学学报(自然科学版), 2020, 40(6): 920-926.
[5] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑小血管病诊治共识[J]. 中华神经科杂志, 2015, 48(10): 838-844.
[6] 王伊龙. 周细胞与脑小血管病[J]. 中华脑血管病杂志(电子版), 2021, 15(4): 274.
[7] Wardlaw, J.M., Smith, E.E., Biessels, G.J., et al. (2013) Neuroimaging Standards for Research into Small Vessel Disease and Its Contribution to Ageing and Neurodegeneration. The Lancet Neurology, 12, 822-838. [Google Scholar] [CrossRef] 
[8] Staals, J., Makin, S.D., Doubal, F.N., et al. (2014) Stroke Subtype, Vascular Risk Factors, and Total MRI Brain Small-Vessel Disease Burden. Neurology, 83, 1228-1234. [Google Scholar] [CrossRef] 
[9] Uiterwijk, R., van Oostenbrugge, R.J., Huijts, M., et al. (2016) Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension. Frontiers in Aging Neuroscience, 8, Article No. 301. [Google Scholar] [CrossRef] [PubMed]
[10] Schoppet, M. and Shanahan, C.M. (2008) Role for Alkaline Phos-phatase as an Inducer of Vascular Calcification in Renal Failure. Kidney International, 73, 989-991. [Google Scholar] [CrossRef] [PubMed]
[11] Wannamethee, S.G., Shaper, A.G. and Perry, I.J. (1997) Serum Creati-nine Concentration and Risk of Cardiovascular Disease: A Possible Marker for Increased Risk of Stroke. Stroke, 28, 557-563. [Google Scholar] [CrossRef] 
[12] Salgado, J.V., Souza, F.L., Salgado, B.J. (2013) How to Understand the Association between Cystatin C Levels and Cardiovascular Disease: Imbalance, Counterbalance, or Con-sequence? Journal of Cardiology, 62, 331-335. [Google Scholar] [CrossRef] [PubMed]
[13] Bengtsson, E., To, F., Grubb, A., et al. (2005) Absence of the Pro-tease Inhibitor Cystatin C in Inflammatory Cells Results in Larger Plaque Area in Plaque Regression of apoE-Deficient Mice. Atherosclerosis, 180, 45-53. [Google Scholar] [CrossRef] [PubMed]
[14] Ni, L., Lu, J., Hou, L.B., et al. (2007) Cystatin C, As-sociated with Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese. Stroke, 38, 3287-3288. [Google Scholar] [CrossRef] 
[15] Huang, G., Liu, H., Zhou, Y., et al. (2018) Association between Cystatin C and SVD in Chinese Population. Neurological Sciences, 39, 2197-2202. [Google Scholar] [CrossRef] [PubMed]
[16] 吴向军, 王庆元, 刘海涛, 等. 胱抑素C对兔血管成形术后再狭窄中血管外膜的影响[J]. 中华老年医学杂志, 2015, 34(4): 441-445.

为你推荐