回顾性分析氨茶碱注射液对脓毒性休克患者毛细血管渗漏的影响
The Effect of Aminophylline Injection on Capillary Leakage in Patients with Septic Shock Was Retrospectively Analyzed
摘要: 目的：分析常规剂量氨茶碱注射液对脓毒性休克患者毛细血管渗漏的影响。方法：采用回顾性分析，选取我院2018年08月~2021年07月收治的脓毒性休克患者共83例，按照治疗过程中是否使用氨茶碱注射液分为A组(n = 41)及B组(n = 42)。A组接受常规治疗(液体复苏、抗感染、稳定血流动力学、呼吸功能支持等措施)，B组在常规治疗的基础上静脉泵注氨茶碱注射液500 mg∙qd，比较两组患者治疗前及治疗48 h后的毛细血管渗漏指数(CLI)变化。结果：经治疗48小时后，B组CLI较A组下降更明显(P < 0.05)，死亡率低于A组。结论：氨茶碱注射液可减轻脓毒性休克患者毛细血管的渗漏，降低死亡率。
Abstract: Objective: To analyze the effect of aminophylline on capillary leakage influence in patients with septic shock. Methods: A total of 83 patients with septic shock admitted to our hospital from August 2018 to July 2021 were retrospectively analyzed and divided into group A (n = 41) and group B (n = 42) according to whether aminophylline injection was used in the treatment process. Group A re-ceived routine treatment (fluid resuscitation, anti-infection, hemodynamics stabilization, respira-tory function support, etc.), and group B received intravenous infusion of aminophylline injection 500 mg∙qd on the basis of routine treatment. The changes of capillary leakage index (CLI) between the two groups were compared before treatment and 48 h after treatment. Results: After 48 hours of treatment, the capillary leakage index (CLI) in group B decreased more significantly than that in group A (P < 0.05). Conclusion: Aminophylline injection can reduce capillary leakage in patients with septic shock.
文章引用：黎海燕, 李波, 刘俊, 李泰兴, 陈敏, 刘跃昆. 回顾性分析氨茶碱注射液对脓毒性休克患者毛细血管渗漏的影响[J]. 临床医学进展, 2022, 12(6): 5370-5374. https://doi.org/10.12677/ACM.2022.126778

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