核壳结构Cu2-xSe@PDA纳米粒子的合成及肿瘤光热治疗应用研究
Synthesis of Core-Shell Nanostructured Cu2-xSe@PDA Nanoparticles and Application for Photothermal Therapy of Tumor
摘要: 利用原位自聚合的方法合成了核壳结构的Cu2-xSe@PDA的单分散性的纳米粒子。由于聚多巴胺壳层的存在，使得纳米粒子具有非常优异的生物相容性。此外，该纳米粒子还可以吸收近红外光并将其转换为热能用于肿瘤的光热治疗。体外细胞实验结果表明，在808 nm近红外光照射5 min，纳米粒子对MCF-7肿瘤细胞的杀死率达到了95%以上，显示出其在肿瘤光热治疗领域应用的巨大潜力。
Abstract: The core-shell structured Cu2-xSe@PDA nanoparticles have been synthesized by in situ self-poly- merization approach, which displayed the monodispersity in an aqueous solution. The obtained nanoparticles have excellent biocompatibility due to the shell of polydopamine. Additionally, Cu2-xSe@PDA nanoparitcles can convert near-infrared light into heat for photothermal therapy of tumors. The in vitro experimental result indicated that the nanoparticles can kill >95 % of MCF-7 cells under 808 nm near-infrared light irradiation with 5 min, showing their great potential in phototherapy of cancer.
文章引用：殷吴杰, 庄家仪, 秦茜茹, 杨佳文, 景丹妮, 陈娇, 汪洋. 核壳结构Cu2-xSe@PDA纳米粒子的合成及肿瘤光热治疗应用研究[J]. 纳米技术, 2022, 12(3): 89-96. https://doi.org/10.12677/NAT.2022.123011

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