|
[1]
|
Aleti, S., Pal, R., Dutta, P., et al. (2020) Prevalence and Predictors of Osteopenia and Osteoporosis in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study from a Tertiary Care Institute in North India. International Journal of Dia-betes in Developing Countries, 40, 262-268. [Google Scholar] [CrossRef]
|
|
[2]
|
Murray, C.E. and Coleman, C.M. (2019) Impact of Diabetes Mellitus on Bone Health. International Journal of Molecular Sciences, 20, 4873. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Rangel, E.B., Rodrigues, C.O. and de Sa, J.R. (2019) Micro and Macrovascular Complications in Ciabetes Mellitus: Pre-Clinical and Clinical Studies. Journal of Diabetes Research, 2019, Article ID: 2161085. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Zheng, Y., Ley, S.H. and Hu, F.B. (2018) Global Aetiology and Epi-demiology of Type 2 Diabetes Mellitus and Its Complications. Nature Reviews Endocrinology, 14, 88-98. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Burge, R., Dawson-Hughes, B., Solomon, D.H., Wong, J.B., King, A. and Tosteson, A. (2007) Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005-2025. Journal of Bone and Mineral Research, 22, 465-475. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Aziziyeh, R., Amin, M., Habib, M., Garcia Perlaza, J., Szafranski, K., McTavish, R.K., et al. (2019) The Burden of Osteoporosis in Four Latin American Countries: Brazil, Mexico, Colombia, and Argentina. Journal of Medical Economics, 22, 638-644. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Mohd-Tahir, N.A. and Li, S.C. (2017) Economic Burden of Osteoporosis-Related Hip Fracture in Asia: A Systematic Review. Osteoporosis International, 28, 2035-2044. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Giambastiani, B.M.S. (2007) Evoluzione Idrologica ed Idrogeo-logica della Pineta di San Vitale (Ravenna). Ph.D. Thesis, Bologna University, Bologna.
|
|
[9]
|
Botolin, S., Faugere, M.C., Malluche, H., Orth, M., Meyer, R. and McCabe, L.R. (2005) Increased Bone Adiposity and Peroxisomal Prolifera-tor-Activated Receptor-Gamma2 Expression in Type I Diabetic Mice. Endocrinology, 146, 3622-3631. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
吴海清. 2型糖尿病与骨质疏松症的关系[J]. 天津医科大学学报, 2011, 17(2): 286-289.
|
|
[11]
|
时进义. 糖尿病胰岛功能与骨密度相关分析[J]. 慢性病学杂志, 2010, 12(7): 599-600.
|
|
[12]
|
张洁, 沈默宇, 成金罗. 2型糖尿病患者骨密度的相关因素[J]. 中国老年学杂志, 2012, 32(15): 3186-3188.
|
|
[13]
|
赵豫梅, 刘婷, 李洁, 等. 绝经后2型糖尿病并发骨质疏松患者骨转换标志物的变化及相关因素[J]. 中华骨质疏松和骨矿盐疾病杂志, 2016, 9(1): 27-31.
|
|
[14]
|
温玉波. 2型糖尿病并发骨质疏松症的多因素分析[J]. 临床合理用药杂志, 2016, 9(22): 143-144.
|
|
[15]
|
Asano, M., Fukui, M., Hosoda, H., Shiraishi, E., Harusato, I., Kadono, M., Tanaka, M., Hasegawa, G., Yoshikawa, T. and Nakamura, N. (2008) Bone Stiffness in Men with Type 2 Diabetes Mellitus. Metabolism, 57, 1691-1695. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
付绍婷, 王晓慧. 雄激素和雄激素受体对骨代谢的调控及机制研究进展[J]. 中国细胞生物学学报, 2018, 40(6): 1041-1048.
|
|
[17]
|
La Cava, A., Alviggi, C. and Matarese, G. (2004) Unraveling the Multiple Roles of Leptin in Inflammation and Autoimmunity. Journal of Molecular Medicine, 82, 4-11. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Kanabrocki, E.L., Hermida, R.C., Wright, M., Young, R.M., Bremner, F.W., Third, J.L., Ryan, M.D., Ayala, D.E., Johnson, M., Nemchausky, B.A., Shirazi, P., Scheving, L.E. and Olwin, J.H. (2001) Circadian Variation of Serum Leptin in Healthy and Diabetic Men. Chronobiology International, 18, 273-283. [Google Scholar] [CrossRef]
|
|
[19]
|
肖新怀, 陈澍, 苏丽芳. 老年2型糖尿病患者瘦素与骨量关系的研究[J]. 实用医学杂志, 2005, 21(1): 41-42.
|
|
[20]
|
Bandeira, E., Neves, A.P., Costa, C., et al. (2012) Association be-tween Vascular Calcification and Osteoporosis in Men with Type 2 Diabetes. Journal of Clinical Densitometry, 15, 55-60. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Ma, R., Wang, L., Zhao, B., Liu, C., Liu, H., Zhu, R., Chen, B., Li, L., Zhao, D., Mo, F., Li, Y, Niu, J., Jiang, G., Fu, M., Bromme, D., Gao, S. and Zhang, D. (2017) Diabetes Per-turbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats. Cellular Physiology and Biochemistry, 41, 55-66. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Almeida, M., Han, L., Martin-Millan, M., Plotkin, L.I., Stewart, S.A., Roberson, P.K., Kousteni, S., O’Brien, C.A., Bellido, T., Parfitt, A.M., Weinstein, R.S., Jilka, R.L. and Manolagas, S.C. (2007) Skeletal Involution by Age-Associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids. Journal of Biological Chemistry, 282, 27285-27297. [Google Scholar] [CrossRef]
|
|
[23]
|
Romagnoli, C., Marcucci, G., Favilli, F., et al. (2013) Role of GSH/GSSG Redox Couple in Osteogenic Activity and Osteoclastogenic Markers of Human Osteoblast-Like SaOS-2 Cells. FEBS Journal, 280, 867-879. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
孔婧. 抗氧化治疗老年糖尿病性骨质疏松的效果研究[J]. 现代诊断与治疗, 2015, 26(20): 4730-4731.
|
|
[25]
|
王凯, 宋敏, 文皓楠, 等. 从OPG/RANK/RANKL信号转导系统探讨老年性骨质疏松的发病机制[J]. 中国骨质疏松杂志, 2020, 26(6): 910-914.
|
|
[26]
|
Sato, K., Suematsu, A., Okamoto, K., Ya-maguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., Cua, D.J. and Takayanagi, H. (2006) Th17 Functions as Anosteoclastogenic Helper T Cell Subset That Links T Cell Activation and Bone Destruction. Journal of Experimental Medicine, 203, 2673-2682. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
江玮, 林硕, 曾龙驿. 初诊断2型糖尿病患者外周血中性粒细胞/淋巴细胞比值变化的临床研究[J]. 中华肥胖与代谢病电子杂志, 2016, 2(3): 156-160.
|
|
[28]
|
Montagnani, A., Gonnelli, S., Alessandri, M. and Nuti, R. (2011) Osteoporosis and Risk of Fracture in Patients with Diabetes: An Update. Aging Clinical and Experimental Research, 23, 84-90. [Google Scholar] [CrossRef]
|
|
[29]
|
Ni, Y., Li, H., Zhang, Y., Zhang, H., Pan, Y., Ma, J. and Wang, L. (2014) Association of IL-6 G-174C Polymorphism with Bone Mineral Density. Journal of Bone and Mineral Metabolism, 32, 167-173. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Narimiya, T., Kanzaki, H., Yamaguchi, Y., et al. (2019) Nrf2 Ac-tivation in Osteoblasts Suppresses Osteoclastogenesis via Inhibiting IL-6 Expression. Bone Reports, 11, Article ID: 100228. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Mirza, S., Hossain, M., Mathews, C., Martinez, P., Pino, P., Gay, J.L., Rentfro, A., McCormick, J.B. and Fisher-Hoch, S.P. (2012) Type 2-Diabetes Is Associated with Elevated Levels of TNF-Alpha, IL-6 and Adiponectin and Low Levels of Leptin in a Population of Mexican Americans: A Cross-Sectional Study. Cytokine, 57, 136-142. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
高明, 王涤非, 林奕辰, 等. 糖尿病肾病患者骨密度及骨代谢标志物的临床研究[J]. 中国骨质疏松杂志, 2014, 20(2): 166-170.
|
|
[33]
|
Eshraghian, A. (2017) Bone Metabolism in Non-Alcoholic Fatty Liver Disease: Vitamin D Status and Bone Mineral Density. Minerva Endocrinology, 42, 164-172. [Google Scholar] [CrossRef]
|
|
[34]
|
Shah, B., Rockman, C.B., Guo, Y., Chesner, J., Schwartzbard, A.Z., Weintraub, H.S., Adelman, M.A., Riles, T.S. and Berger, J.S. (2014) Diabetes and Vascular Dis-ease in Different Arterial Territories. Diabetes Care, 37, 1636-1642. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Zhong, N., et al. (2018) Microangiopathy Is Associated with Bone Loss in Female Type 2 Diabetes Mellitus Patients. Diabetes and Vascular Disease Research, 15, 433-441. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Cui, R., Sun, S.Q., Zhong, N., Xu, M.X., Cai, H.D., Zhang, G., Qu, S. and Sheng, H. (2020) The Relationship between Atherosclerosis and Bone Mineral Density in Patients with Type 2 Diabetes Depends on Vascular Calcifications and Sex. Osteoporosis International, 31, 1135-1143. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Negre-Salvayre, A., Salvayre, R., Augé, N., Pamplona, R. and Portero-Otín, M. (2009) Hyperglycemia and Glycation in Diabetic Complications. Antioxidants & Redox Signaling, 11, 3071-3109. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Khan, N., Bakshi, K.S., Jaggi, A.S. and Singh, N. (2009) Ameliorative Potential of Spironolactone in Diabetes Induced Hyperalgesia in Mice. Yakugaku Zasshi, 129, 593-599. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Alikhani, M., Alikhani, Z., Boyd, C., MacLellan, C.M., Raptis, M., Liu, R., Pischon, N., Trackman, P.C., Gerstenfeld, L. and Graves, D.T. (2007) Advanced Glycation End Products Stim-ulate Osteoblast Apoptosis via the MAP Kinase and Cytosolic Apoptotic Pathways. Bone, 40, 345-353. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
程群, 朱汉民. 骨质疏松和动脉钙化的研究进展[J]. 中国骨质疏松杂志, 2003, 9(4): 364-367.
|
|
[41]
|
Sugiyama, T., Okuno, T., Fukuhara, M., Oku, H., Ikeda, T., Obayashi, H., Ohta, M., Fukui, M., Hasegawa, G. and Nakamura, N. (2007) Angiotensin II Receptor Blocker Inhibits Abnormal Accumula-tion of Advanced Glycation End Products and Retinal Damage in a Rat Model of Type 2 Diabetes. Experimental Eye Re-search, 85, 406-412. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Yamada, H., Yamada, E., Higuchi, A. and Matsumura, M. (2005) Retinal Neovascularisation without Ischaemia in the Spontaneously Diabetic Torii Rat. Diabetologia, 48, 1663-1668. [Google Scholar] [CrossRef] [PubMed]
|
|
[43]
|
Mohr, M., Helge, E.W., Petersen, L.F., et al. (2015) Effects of Soccer vs Swim Training on Bone Formation in Sedentary Middle-Aged Women. European Journal of Applied Physiol-ogy, 115, 2671-2679. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Jang, W.G., Kim, E.J., Bae, I.H., et al. (2011) Metformin Induces Osteoblast Differentiation via Orphan Nuclear Receptor SHP-Mediated Transactivation of Runx2. Bone, 48, 885-893. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
庞晓娜, 胡予. 二甲双胍与骨质疏松的关系[J]. 中国骨质疏松杂志, 2012, 18(8): 764-766, 724.
|
|
[46]
|
房玲玲, 张启华. 2型糖尿病合并骨质疏松症的相关影响因素分析[J]. 现代实用医学, 2014, 26(12): 1537-1539.
|
|
[47]
|
Vestergaard, P., Rejnmark, L. and Mosekilde, L. (2005) Relative Fracture Risk in Patients with Diabetes Mellitus, and the Impact of Insulin and Oral Antidiabetic Medication on Relative Fracture Risk. Diabetologia, 48, 1292-1299. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Lapane, K.L., Jesdale, B.M., Dubé, C.E., Pimentel, C.B. and Raj-pathak, S.N. (2015) Sulfonylureas and Risk of Falls and Fractures among Nursing Home Residents with Type 2 Diabe-tes Mellitus. Diabetes Research and Clinical Practice, 109, 411-419. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Ma, P., Gu, B., Xiong, W., et al. (2014) Glimepiride Promotes Osteogenic Differentiation in Rat Osteoblasts via the PI3K/Akt/eNOS Pathway in a High Glucose Microenvironment. PLOS ONE, 9, e112243. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Kanazawa, I., Yamaguchi, T., Yamamoto, M. and Sugimoto, T. (2010) Relationship between Treatments with Insulin and Oral Hypoglycemic Agents versus the Presence of Vertebral Fractures in Type 2 Diabetes Mellitus. Journal of Bone and Mineral Metabolism, 28, 554-560. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Monami, M., Cresci, B., Colombini, A., Pala, L., Balzi, D., Gori, F., Chiasserini, V., Marchionni, N., Rotella, C.M. and Mannucci, E. (2008) Bone Fractures and Hypoglycemic Treatment in Type 2 Diabetic Patients: A Case-Control Study. Diabetes Care, 31, 199-203. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Grey, A., Bolland, M., Gamble, G., Wattie, D., Horne, A., Davidson, J., et al. (2007) The Peroxisome Proliferator-Activated Receptor Gamma Agonist Rosiglitazone Decreases Bone Formation and Bone Mineral Density in Healthy Postmenopausal Women: A Randomized, Controlled Trial. The Journal of Clinical Endocrinology & Metabolism, 92, 1305-1310. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Viscoli, C.M., Inzucchi, S.E., Young, L.H., Insogna, K.L., Conwit, R., Furie, K.L., et al. (2017) Pioglitazone and Risk for Bone Fracture: Safety Data from a Randomized Clinical Trial. The Journal of Clinical Endocrinology & Metabolism, 102, 914-922.
|
|
[54]
|
Benvenuti, S., Cellai, I., Luciani, P., Deledda, C., Baglioni, S., Giuliani, C., Saccardi, R., Mazzanti, B., Dal Pozzo, S., Mannucci, E., Peri, A. and Serio, M. (2007) Rosiglitazone Stimulates Adipogenesis and Decreases Osteo-blastogenesis in Human Mesenchymal Stem Cells. Journal of Endocrinological Investigation, 30, RC26-RC30. [Google Scholar] [CrossRef]
|
|
[55]
|
Zhu, Z.N., Jiang, Y.F. and Ding, T. (2014) Risk of Fracture with Thia-zolidine Ediones: An Updated Meta-Analysis of Randomized Clinical Trials. Bone, 68, 115-123. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Schwartz, A.V., Sellmeyer, D.E., Vittinghoff, E., Palermo, L., Lecka-Czernik, B., Feingold, K.R., et al. (2006) Thiazolidinedione Use and Bone Loss in Older Diabetic Adults. The Journal of Clinical Endocrinology & Metabolism, 91, 3349-3354. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Eriksson, R., Broberg, B.V., Ishoy, P.L., et al. (2019) Bone Status in Obese, Non-Diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Ex-enatide on Bone Turnover Markers and Bone Mineral Density. Frontiers in Psychiatry, 9, Article No. 781. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
Schiellerup, S.P., Skov-Jeppesen, K., Windeløv, J.A., et al. (2019) Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment. Fron-tiers in Endocrinology (Lausanne), 10, Article No. 75. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Bilezikian, J.P., Watts, N.B., Usiskin, K., Polidori, D., Fung, A., Sullivan, D., et al. (2016) Evaluation of Bone Mineral Density and Bone Biomarkers in Patients with Type 2 Diabetes Treated with Canagliflozin. The Journal of Clinical Endocrinology & Metabolism, 101, 44-51. [Google Scholar] [CrossRef] [PubMed]
|
|
[60]
|
Blau, J.E., Bauman, V., Conway, E.M., Piaggi, P., Walter, M.F., Wright, E.C., et al. (2018) Canagliflozin Triggers the FGF23/1,25-dihydroxyvitamin D/PTH Axis in Healthy Volunteers in a Randomized Crossover Study. JCI Insight, 3, e99123. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Napoli, N., Chandran, M., Pierroz, D.D., Abrahamsen, B., Schwartz, A.V., Ferrari, S.L., et al. (2017) Mechanisms of Diabetes Mellitus-Induced Bone Fragility. Nature Reviews Endocrinol-ogy, 13, 208-219. [Google Scholar] [CrossRef] [PubMed]
|
|
[62]
|
Tang, H.L., Li, D.D., Zhang, J.J., Hsu, Y.H., Wang, T.S., Zhai, S.D., et al. (2016) Lack of Evidence for a Harmful Effect of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors on Fracture Risk among Type 2 Diabetes Patients: A Network and Cumulative Meta-Analysis of Randomized Controlled Trials. Di-abetes, Obesity and Metabolism, 18, 1199-1206. [Google Scholar] [CrossRef] [PubMed]
|
|
[63]
|
Ljunggren, O., Bolinder, J., Johansson, L., Wilding, J., Langkilde, A.M., Sjostrom, C.D., et al. (2012) Dapagliflozin Has No Effect on Markers of Bone Formation and Resorption or Bone Mineral Density in Patients with Inadequately Controlled Type 2 Diabetes Mellitus on Metformin. Diabetes, Obesity and Metabolism, 14, 990-999. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Walsh, J.S. and Vilaca, T. (2017) Obesity, Type 2 Diabetes and Bone in Adults. Calcified Tissue International, 100, 528-535. [Google Scholar] [CrossRef] [PubMed]
|
|
[65]
|
Iwaniec, U.T., Dube, M.G., Boghossian, S., Song, H., Helferich, W.G., Turner, R.T. and Kalra, S.P. (2009) Body Mass Influences Cortical Bone Mass Independent of Leptin Signaling. Bone, 44, 404-412. [Google Scholar] [CrossRef] [PubMed]
|
|
[66]
|
Lane, N.E. (2006) Epidemiology, Etiology, and Diagnosis of Os-teoporosis. American Journal of Obstetrics & Gynecology, 194, S3-S11. [Google Scholar] [CrossRef] [PubMed]
|