长链非编码RNA在慢性肾脏疾病中的研究进展
Research Progress of Long Non-Coding RNA in Chronic Kidney Disease
DOI: 10.12677/ACM.2022.126792, PDF,    科研立项经费支持
作者: 谢丹丹：济宁医学院临床医学院，山东 济宁；刘 雷*：济宁医学院附属医院全科医学科，山东 济宁
关键词: 长链非编码RNA；慢性肾脏疾病；发病机制；Long Non-Coding RNA； Chronic Kidney Disease； Pathogenesis
摘要: 慢性肾脏病(Chronic Kidney Disease, CKD)是全球性公共卫生问题，患病率在11%至13%之间。其主要病因有膜性肾病、糖尿病肾病、以及各种炎症、免疫所介导的肾小球疾病。长链非编码RNA (long non-coding RNA, lncRNA)是由大于200个核苷酸组成，lncRNA是无蛋白质编码功能的RNA分子，近年来越来越多的研究发现，lncRNA可能是调节细胞多种生物学过程的关键调节剂。已有许多的研究证据表明，lncRNA与肾脏疾病的发生发展有着密切的联系，进一步深入地研究lncRNA，也许其可成为肾脏疾病新的生物标志物和新的治疗靶点，为该疾病的诊断和预测其发生发展提供新的思路。本综述总结了近年lncRNA在慢性肾脏疾病方面的研究进展。
Abstract: Chronic kidney disease (CKD) is a global public health problem. The global prevalence of CKD is very high, and the prevalence of CKD is between 11% and 13%. The main causes are membranous nephropathy, diabetic nephropathy and glomerular diseases mediated by various inflammatory and immune diseases. Long non-coding RNA (lncRNA) is composed of more than 200 nucleotides, and lncRNA is an RNA molecule with no protein-coding function. In recent years, more and more studies have found that lncRNA may be a key regulator of many biological processes in cells. Many studies have shown that lncRNA is closely related to the occurrence and development of kidney diseases. Further studies on lncRNA may become a new biomarker and a new therapeutic target for kidney diseases, providing new ideas for the diagnosis and prediction of the occurrence and devel-opment of this disease. This review summarizes the research progress of lncRNA in chronic kidney diseases in recent years.
文章引用：谢丹丹, 刘雷. 长链非编码RNA在慢性肾脏疾病中的研究进展[J]. 临床医学进展, 2022, 12(6): 5477-5484. https://doi.org/10.12677/ACM.2022.126792

参考文献

[1] Li, Y.H., Yang, J. and Li, C.-Y. (2021) Research Progress on the Role of Long Non-Coding RNA in Cervical Cancer. Chinese Journal of Cancer Biotherapy, 28, 398-404.
[2] Hill, N.R., Fatoba, S.T., Oke, J.L., et al. (2017) Global Prev-alence of Chronic Kidney Disease—A Systematic Review and Meta-Analysis. PLOS ONE, 11, e0158765. [Google Scholar] [CrossRef] [PubMed]
[3] Zhang, L.X., Wang, F., Wang, L., et al. (2012) Prevalence of Chronic Kidney Disease in China: A Cross-Sectional Survey. The Lancet, 379, 815-822. [Google Scholar] [CrossRef] 
[4] Rashid, F., Shah, A. and Shan, G. (2016) Long Non-Coding RNAs in the Cytoplasm. Genomics Proteomics Bioinformatics, 14, 73-80. [Google Scholar] [CrossRef] [PubMed]
[5] Kung, J.T.Y., Colognori, D. and Lee, J.T. (2013) Long Noncoding RNAs: Past, Present, and Future. Genetics, 193, 651-669. [Google Scholar] [CrossRef] [PubMed]
[6] Moran, V.A., Perera, R.J. and Khalil, A.M. (2012) Emerging Functional and Mechanistic Paradigms of Mammalian Long Non-Coding RNAs. Nucleic Acids Research, 40, 6391-6400. [Google Scholar] [CrossRef] [PubMed]
[7] Cheng, J., Kapranov, P., Drenkow, J., et al. (2005) Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution. Science, 308, 1149-1154. [Google Scholar] [CrossRef] [PubMed]
[8] Brosnan, C.A. and Voinnet, O. (2009) The Long and the Short of Noncoding RNAs. Current Opinion in Cell Biology, 21, 416-425. [Google Scholar] [CrossRef] [PubMed]
[9] Kour, S. and Rath, P.C. (2016) Long Noncoding RNAs in Aging and Age-Related Diseases. Ageing Research Reviews, 26, 1-21. [Google Scholar] [CrossRef] [PubMed]
[10] Xiao, T.F., Liu, L.H., Li, H.L., et al. (2015) Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Ac-tivating C/EBPα. Stem Cell Reports, 5, 856-865. [Google Scholar] [CrossRef] [PubMed]
[11] Ogawa, Y., Sun, B.K. and Lee, J.T. (2008) Intersection of the RNA Interference and X-Inactivation Pathways. Science, 320, 1336-1341. [Google Scholar] [CrossRef] [PubMed]
[12] Pefanis, E., Wang, J.G., Rothschild, G., et al. (2015) RNA Exo-some-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity. Cell, 161, 774-789. [Google Scholar] [CrossRef] [PubMed]
[13] Paraskevopoulou, M.D., Georgakilas, G., Kostoulas, N., et al. (2013) DIANA-LncBase: Experimentally Verified and Computationally Predicted microRNA Targets on Long Non-Coding RNAs. Nucleic Acids Research, 41, D239-D245. [Google Scholar] [CrossRef] [PubMed]
[14] Wang, K.C. and Chang, H.Y. (2011) Molecular Mechanisms of Long Noncoding RNAs. Molecular Cell, 43, 904-914. [Google Scholar] [CrossRef] [PubMed]
[15] Nagano, T. and Fraser, P. (2011) No-Nonsense Functions for Long Noncoding RNAs. Cell, 145, 178-181. [Google Scholar] [CrossRef] [PubMed]
[16] Clark, M.B. and Mattick, J.S. (2011) Long Noncoding RNAs in Cell Biology. Seminars in Cell and Developmental Biology, 22, 366-376. [Google Scholar] [CrossRef] [PubMed]
[17] Mattick, J.S., Amaral, P.P., Dinger, M.E., et al. (2009) RNA Regulation of Epigenetic Processes. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, 31, 51-59. [Google Scholar] [CrossRef] [PubMed]
[18] Khalil, A.M. and Rinn, J.L. (2011) RNA-Protein Interactions in Human Health and Disease. Seminars in Cell and Developmental Biology, 22, 359-365. [Google Scholar] [CrossRef] [PubMed]
[19] Koziol, M.J. and Rinn, J.L. (2010) RNA Traffic Control of Chromatin Complexes. Current Opinion in Genetics & Development, 20, 142-148. [Google Scholar] [CrossRef] [PubMed]
[20] Khalil, A.M., Guttman, M., Huarte, M., et al. (2009) Many Human Large Intergenic Noncoding RNAs Associate with Chromatin-Modifying Complexes and Affect Gene Expression. Pro-ceedings of the National Academy of Sciences of the United States of America, 106, 11667-11672. [Google Scholar] [CrossRef] [PubMed]
[21] Mitchell, G., Ido, A., Manuel, G., et al. (2009) Chromatin Signature Reveals over a Thousand Highly Conserved Large Non-Coding RNAs in Mammals. Nature, 458, 223-227. [Google Scholar] [CrossRef] [PubMed]
[22] Huarte, M., Guttman, M., Feldser, D., et al. (2010) A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response. Cell, 142, 409-419. [Google Scholar] [CrossRef] [PubMed]
[23] Hung, T., Wang, Y.L., Lin, M.F., et al. (2011) Extensive and Coor-dinated Transcription of Noncoding RNAs within Cell-Cycle Promoters. Nature Genetics, 43, 621-629. [Google Scholar] [CrossRef] [PubMed]
[24] Kino, T., Hurt, D.E., Ichijo, T., et al. (2010) Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor. Science Signaling, 3, ra8. [Google Scholar] [CrossRef] [PubMed]
[25] Millis, M.P., Bowen, D., Kingsley, C., et al. (2007) Variants in the Plasmacytoma Variant Translocation Gene (PVT1) Are Associated with End-Stage Renal Disease Attributed to Type 1 Diabetes. Diabetes, 56, 3027-3032. [Google Scholar] [CrossRef] [PubMed]
[26] Hanson, R.L., Craig, D.W., Millis, M.P., et al. (2007) Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Sin-gle Nucleotide Polymorphism Association Study. Diabetes, 56, 975-983. [Google Scholar] [CrossRef] [PubMed]
[27] Maestroni, S. and Zerbini, G. (2018) Glomerular Endothelial Cells versus Podocytes as the Cellular Target in Diabetic Nephropathy. Acta Diabetologica, 55, 1105-1111. [Google Scholar] [CrossRef] [PubMed]
[28] Ye, F., Xiao, F. and Song, C.X. (2020) Long Non-Coding RNA PVT1 Regulates Podocyte Injury and Apoptosis in Diabetic Nephropathy. Chinese Journal of Integrated Traditional and Western Medicine Nephropathy, 21, 608-610.
[29] Zhong, W., Zeng, J.E., Xue, J.L., et al. (2020) Knockdown of lncRNA PVT1 Alleviates High Glucose-Induced Proliferation and Fibrosis in Human Mesangial Cells by miR-23b-3p/WT1 Axis. Diabetology & Metabolic Syndrome, 12, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[30] Zang, X.-J., Li, L., Du, X., Yang, B. and Mei, C.-L. (2019) LncRNA TUG1 Inhibits the Proliferation and Fibrosis of Mesangial Cells in Diabetic Nephropathy via Inhibiting the PI3K/AKT Pathway. European Review for Medical and Pharmacological Sciences, 23, 7519-7525.
[31] Duan, L.-J., Ding, M., Hou, L.-J., et al. (2017) Long Noncoding RNA TUG1 Alleviates Extracellular Matrix Accumulation via Me-diating microRNA-377 Targeting of PPARγ in Diabetic Nephropathy. Biochemical and Biophysical Research Commu-nications, 484, 598-604. [Google Scholar] [CrossRef] [PubMed]
[32] Fan, X.B., Zhang, P.J., Wang, X.M., Wu, B., Wang, J. and Wu, Y.L. (2019) Expression and Clinical Significance of Serum LncRNA TUG1 in Patients with Early Diabetic Nephropathy. Chinese Journal of Integrated Traditional and Western Medicine Nephropathy, 22, 982-984.
[33] Feng, X.Z., Zhao, J., Ding, J.J., et al. (2019) LncRNA Blnc1 Expression and Its Effect on Renal Fibrosis in Diabetic Nephropathy. American Journal of Translational Research, 11, 5664-5672.
[34] Huang, Y.-S., Hsieh, H.-Y., Shih, H.-M., et al. (2014) Urinary Xist Is a Potential Biomarker for Membranous Nephropathy. Biochemical and Biophysical Research Communications, 452, 415-421. [Google Scholar] [CrossRef] [PubMed]
[35] Jin, L.W., Pan, M., Ye, H.Y., et al. (2019) Down-Regulation of the Long Non-Coding RNA XIST Ameliorates Podocyte Apoptosis in Membranous Nephropathy via the miR-217-TLR4 Pathway. Experimental Physiology, 104, 220-230.
[36] Guo, S.W., Wei, S.C., Luo, J.W., et al. (2018) LncRNA Ex-pression in Peripheral Blood of Autosomal Dominant Polycystic Kidney Disease. Chinese Journal of Integrated Tradi-tional and Western Medicine Nephropathy, 19, 242-247+4.
[37] Iyer, M.K., Niknafs, Y.S., Malik, R., et al. (2015) The Landscape of Long Noncoding RNAs in the Human Transcriptome. Nature Genetics, 47, 199-208. [Google Scholar] [CrossRef] [PubMed]
[38] Karam, A., Shayan, F., Mohammed, K., et al. (2018) Long Noncoding RNA Hoxb3os Is Dysregulated in Autosomal Dominant Polycystic Kidney Disease and Regulates mTOR Signaling. Journal of Biological Chemistry, 293, 9388-9398. [Google Scholar] [CrossRef] 
[39] Li, Y.C. and Li, Y. (2020) Research Progress of Randall Plaque of Renal Calculus. Journal of Central South University, 45, 435-439.
[40] Hertz, J.M., Juncker, I., Persson, U., et al. (2001) Detection of Mutations in the COL4A5 Gene by SSCP in X-Linked Alport Syndrome. Human Mutation, 18, 141-148. [Google Scholar] [CrossRef] [PubMed]
[41] Huang, D. (2020) Expression of Long Non-Coding RNA SOX2-OT in Peripheral Blood Mononuclear Cells of Patients with Lupus Nephritis and Its Significance. Youjiang Medical University For Nationalities, Baise.
[42] Wu, G.-C., Li, J., Leng, R.-X., et al. (2017) Identification of Long Non-Coding RNAs GAS5, linc0597 and lnc-DC in Plasma as Novel Bi-omarkers for Systemic Lupus Erythematosus. Oncotarget, 8, 23650-23663. [Google Scholar] [CrossRef] [PubMed]
[43] Zhang, L.H., Xiao, B., Zhong, M., et al. (2020) LncRNA NEAT1 Accelerates Renal Mesangial Cell Injury via Modulating the miR-146b/TRAF6/NF-κB Axis in Lupus Nephritis. Cell and Tissue Research, 382, 627-638. [Google Scholar] [CrossRef] [PubMed]
[44] Guo, H., Li, R.S. and Luo, J. (2009) Expression of An-ti-Nucleosome Antibody and Anti-Double-Stranded DNA in Serum of Lupus Nephritis and Its Clinical Significance. Clinical Medicine Practice, 18, 814-816.

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