MicroRNA-155与结核分枝杆菌感染的相关研究进展
Research Progress on MicroRNA-155 Associated with Mycobacterium tuberculosis Infection
DOI: 10.12677/ACM.2022.126794, PDF,   
作者: 何定海:青海大学研究生院,青海 西宁;崔金霞*:青海大学附属医院呼吸与危重症医学科,青海 西宁
关键词: MicroRNA-155结核分枝杆菌诊断 MicroRNA-155 Mycobacterium tuberculosis Diagnosis
摘要: 结核病是人类面对的主要慢性传染病之一,在诊断和治疗方面仍充满挑战。微小RNA (microRNA, miRNA)是一类在转录后水平调节基因表达的非编码RNA分子。大量研究表明,miR-155作为一个多功能miRNA,和结核病发生发展密切相关,在结核感染后的凋亡、自噬、细胞极化等活动中发挥免疫调节作用。有可能成为新的诊断标记物和治疗靶点。
Abstract: Tuberculosis remains one of the major chronic infectious diseases faced by humankind, and it is still full of challenges in diagnosis and treatment. MicroRNAs (miRNAs) are a class of noncoding RNA molecules that regulate gene expression at the post transcriptional level. A large number of studies have demonstrated that miR-155, as a multifunctional miRNA, is closely related to the occurrence and development of tuberculosis, and plays an immunomodulatory role in apoptosis, autophagy, cell polarization and other activities after infection. It may become a new diagnostic marker and therapeutic target.
文章引用:何定海, 崔金霞. MicroRNA-155与结核分枝杆菌感染的相关研究进展[J]. 临床医学进展, 2022, 12(6): 5491-5499. https://doi.org/10.12677/ACM.2022.126794

参考文献

[1] (2021) Global Tuberculosis Report 2021. World Health Organization, Geneva.
[2] Nasser Eddine, A. and Kaufmann, S.H. (2005) Improved Protection by Recombinant BCG. Microbes and Infection, 7, 939-946. [Google Scholar] [CrossRef] [PubMed]
[3] Friedman, R.C., Farh, K.K., Burge, C.B. and Bartel, D.P. (2009) Most Mammalian mRNAs Are Conserved Targets of microRNAs. Genome Research, 19, 92-105. [Google Scholar] [CrossRef] [PubMed]
[4] Han, H. (2018) RNA Interference to Knock Down Gene Expression. Methods in Molecular Biology, 1706, 293-302. [Google Scholar] [CrossRef] [PubMed]
[5] Bartel, D.P. (2004) MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. Cell, 116, 281-297. [Google Scholar] [CrossRef
[6] Dombkowski, A.A., Sultana, Z., Craig, D.B. and Jamil, H. (2011) In Silico Analysis of Combinatorial microRNA Activity Reveals Target Genes and Pathways Associated with Breast Cancer Metastasis. Cancer Informatics, 10, 13-29. [Google Scholar] [CrossRef
[7] Fabian, M.R., Sonenberg, N. and Filipowicz, W. (2010) Regulation of mRNA Translation and Stability by microRNAs. Annual Review of Biochemistry, 79, 351-379. [Google Scholar] [CrossRef] [PubMed]
[8] Mahesh, G. and Biswas, R. (2019) MicroRNA-155: A Master Regulator of Inflammation. Journal of Interferon & Cytokine Research, 39, 321-330. [Google Scholar] [CrossRef] [PubMed]
[9] Pashangzadeh, S., Motallebnezhad, M., Vafashoar, F., Khalvandi, A. and Mojtabavi, N. (2021) Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases. Frontiers in Immunology, 12, Article ID: 669382. [Google Scholar] [CrossRef] [PubMed]
[10] Ali Syeda, Z., Langden, S.S.S., Munkhzul, C., Lee, M. and Song, S.J. (2020) Regulatory Mechanism of MicroRNA Expression in Cancer. International Journal of Molecular Sciences, 21, 1723. [Google Scholar] [CrossRef] [PubMed]
[11] O’Brien, J., Hayder, H., Zayed, Y. and Peng, C. (2018) Over-view of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Frontiers in Endocrinology (Lausanne), 9, 402. [Google Scholar] [CrossRef] [PubMed]
[12] Matsuyama, H. and Suzuki, H.I. (2019) Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis. International Journal of Molecular Sciences, 21, 132. [Google Scholar] [CrossRef] [PubMed]
[13] Pasca, S., Jurj, A., Petrushev, B., Tomuleasa, C. and Matei, D. (2020) MicroRNA-155 Implication in M1 Polarization and the Impact in Inflammatory Diseases. Frontiers in Immunology, 11, Article No. 625. [Google Scholar] [CrossRef] [PubMed]
[14] Wu, J., Lu, C., Diao, N., Zhang, S., Wang, S., Wang, F., Gao, Y., Chen, J., Shao, L., Lu, J., Zhang, X., Weng, X., Wang, H., Zhang, W. and Huang, Y. (2012) Analysis of microRNA Expression Profiling Identifies miR-155 and miR-155* as Potential Diagnostic Markers for Active Tuberculosis: A Pre-liminary Study. Human Immunology, 73, 31-37. [Google Scholar] [CrossRef] [PubMed]
[15] Albert, M.L., Sauter, B. and Bhardwaj, N. (1998) Dendritic Cells Acquire Antigen from Apoptotic Cells and Induce Class I-Restricted CTLs. Nature, 392, 86-89. [Google Scholar] [CrossRef] [PubMed]
[16] Ghorpade, D.S., Leyland, R., Kurowska-Stolarska, M., Patil, S.A. and Balaji, K.N. (2012) MicroRNA-155 Is Required for Mycobacterium bovis BCG-Mediated Apoptosis of Macrophages. Molecular and Cellular Biology, 32, 2239-2253. [Google Scholar] [CrossRef
[17] De Santis, R., Liepelt, A., Mossanen, J.C., et al. (2016) miR-155 Targets Caspase-3 mRNA in Activated Macrophages. RNA Biology, 13, 43-58. [Google Scholar] [CrossRef] [PubMed]
[18] Rothchild, A.C., Sissons, J.R., Shafiani, S., Plaisier, C., Min, D., Mai, D., Gilchrist, M., Peschon, J., Larson, R.P., Bergthaler, A., Baliga, N.S., Urdahl, K.B. and Aderem, A. (2016) MiR-155-Regulated Molecular Network Orchestrates Cell Fate in the Innate and Adaptive Immune Response to Myco-bacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 113, E6172-E6181. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, S., Li, F., Jia, S., Zhang, K., Jiang, W., Shang, Y., Chang, K., Deng, S. and Chen, M. (2015) Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Apoptosis of Macrophages via Targeting the microRNA155-SOCS1 Interaction. Cellular Physiology & Biochemistry, 35, 1276-1288. [Google Scholar] [CrossRef] [PubMed]
[20] GBonilla-Muro, M.G., Hernández de la Cruz, O.N., Gonzalez-Barrios, J.A., Alcaráz-Estrada, S.L. and Castañón-Arreola, M. (2021) EsxA Mainly Contributes to the miR-155 Overexpression in Human Monocyte-Derived Macrophages and Potentially Affect the Immune Mechanism of Macrophages through miRNA Dysregulation. Journal of Microbiology, Immunology and Infection, 54, 185-192. [Google Scholar] [CrossRef] [PubMed]
[21] Huang, J., Jiao, J., Xu, W., Zhao, H., Zhang, C., Shi, Y. and Xiao, Z. (2015) MiR-155 Is Upregulated in Patients with Active Tuberculosis and Inhibits Apoptosis of Monocytes by Target-ing FOXO3. Molecular Medicine Reports, 12, 7102-7108. [Google Scholar] [CrossRef] [PubMed]
[22] Kim, J.J., Lee, H.M., Shin, D.M., Kim, W., Yuk, J.M., Jin, H.S., Lee, S.H., Cha, G.H., Kim, J.M., Lee, Z.W., Shin, S.J., Yoo, H., Park, Y.K., Park, J.B., Chung, J., Yoshimori, T. and Jo, E.K. (2012) Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action. Cell Host & Microbe, 11, 457-468. [Google Scholar] [CrossRef] [PubMed]
[23] Jagannath, C., Lindsey, D.R., Dhandayuthapani, S., Xu, Y., Hunter, R.L. and Eissa, N.T. (2009) Autophagy Enhances the Efficacy of BCG Vaccine by Increasing Peptide Presenta-tion in Mouse Dendritic Cells. Nature Medicine, 15, 267-276. [Google Scholar] [CrossRef] [PubMed]
[24] Romagnoli, A., Etna, M.P., Giacomini, E., Pardini, M., Remoli, M.E., Corazzari, M., Falasca, L., Goletti, D., Gafa, V., Simeone, R., Delogu, G., Piacentini, M., Brosch, R., Fimia, G.M. and Coccia, E.M. (2012) ESX-1 Dependent Impairment of Au-tophagic Flux by Mycobacterium tuberculosis in Human Dendritic Cells. Autophagy, 8, 1357-1370. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, J., Yang, K., Zhou, L., Minhaowu, Wu, Y., Zhu, M., Lai, X., Chen, T., Feng, L., Li, M., Huang, C., Zhong, Q. and Huang, X. (2013) MicroRNA-155 Promotes Autophagy to Eliminate In-tracellular Mycobacteria by Targeting Rheb. PLOS Pathogens, 9, e1003697. [Google Scholar] [CrossRef] [PubMed]
[26] Etna, M.P., Sinigaglia, A., Grassi, A., Giacomini, E., Romagnoli, A., Pardini, M., Severa, M., Cruciani, M., Rizzo, F., Anastasiadou, E., Di Camillo, B., Barzon, L., Fimia, G.M., Man-ganelli, R. and Coccia, E.M. (2018) Mycobacterium tuberculosis-Induced miR-155 Subverts Autophagy by Targeting ATG3 in Human Dendritic Cells. PLOS Pathogens, 14, e1006790. [Google Scholar] [CrossRef] [PubMed]
[27] Kumar, R., Halder, P., Sahu, S.K., Kumar, M., Kumari, M., Jana, K., Ghosh, Z., Sharma, P., Kundu, M. and Basu, J. (2012) Identification of a Novel Role of ESAT-6-Dependent miR-155 Induction during Infection of Macrophages with Mycobacterium tuberculosis. Cellular Microbiology, 14, 1620-1631. [Google Scholar] [CrossRef] [PubMed]
[28] Kuijl, C., Savage, N.D., Marsman, M., Tuin, A.W., Janssen, L., Egan, D.A., Ketema, M., van den Nieuwendijk, R., van den Eeden, S.J., Geluk, A., Poot, A., van der Marel, G., Beijersbergen, R.L., Overkleeft, H., Ottenhoff, T.H. and Neefjes, J. (2007) Intracellular Bacterial Growth Is Controlled by a Kinase Network around PKB/AKT1. Nature, 450, 725-730. [Google Scholar] [CrossRef] [PubMed]
[29] Yao, J., Du, X., Chen, S., Shao, Y., Deng, K., Jiang, M., Liu, J., Shen, Z., Chen, X. and Feng, G. (2018) Rv2346c Enhances Mycobacterial Survival within Macrophages by Inhibiting TNF-α and IL-6 Production via the p38/miRNA/NF-κB Pathway. Emerging Microbes & Infections, 7, 158. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, J., Wu, M., Wen, J., Yang, K., Li, M., Zhan, X., Feng, L., Li, M. and Huang, X. (2014) MicroRNA-155 Induction by Mycobacterium bovis BCG Enhances ROS Production through Targeting SHIP1. Molecular Immunology, 62, 29-36. [Google Scholar] [CrossRef] [PubMed]
[31] Qin, Y., Wang, Q., Zhou, Y., Duan, Y. and Gao, Q. (2016) In-hibition of IFN-γ-Induced Nitric Oxide Dependent Antimycobacterial Activity by miR-155 and C/EBPβ. International Journal of Molecular Sciences, 17, 535. [Google Scholar] [CrossRef] [PubMed]
[32] O’Connell, R.M., Rao, D.S., Chaudhuri, A.A. and Baltimore, D. (2010) Physiological and Pathological Roles for microRNAs in the Immune System. Nature Reviews Immunology, 10, 111-122. [Google Scholar] [CrossRef] [PubMed]
[33] Forrest, A.R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Nino-miya, N., et al. (2010) Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, Promotes Monocytic Differen-tiation through Combinatorial Regulation. Leukemia, 24, 460-466. [Google Scholar] [CrossRef] [PubMed]
[34] Chen, L., Gao, D., Shao, Z., Zheng, Q. and Yu, Q. (2020) miR-155 Indicates the Fate of CD4+ T Cells. Immunology Letters, 224, 40-49. [Google Scholar] [CrossRef] [PubMed]
[35] Gein, S.V. and Sharavieva, I.L. (2014) Effect of Rota-tion and Immobilization Stress on IL-1β, IL-2, IL-4, and IFN-γ Production by Splenocytes under Opiate Receptor Blockade in Vivo. Doklady Biological Sciences, 454, 69-71. [Google Scholar] [CrossRef
[36] Iwai, H., Funatogawa, K., Matsumura, K., Kato-Miyazawa, M., Kirikae, F., Kiga, K., Sasakawa, C., Miyoshi-Akiyama, T. and Kirikae, T. (2015) MicroRNA-155 Knockout Mice Are Susceptible to Mycobacterium tuberculosis Infection. Tuberculosis (Edinb), 95, 246-250. [Google Scholar] [CrossRef] [PubMed]
[37] Rodriguez, A., Vigorito, E., Clare, S., Warren, M.V., Couttet, P., Soond, D.R., van Dongen, S., Grocock, R.J., Das, P.P., Miska, E.A., Vetrie, D., Okkenhaug, K., Enright, A.J., Dougan, G., Turner, M. and Bradley, A. (2007) Requirement of bic/microRNA-155 for Normal Immune Function. Science, 316, 608-611. [Google Scholar] [CrossRef] [PubMed]
[38] Basak, J. and Majsterek, I. (2021) miRNA-Dependent CD4+ T Cell Differentiation in the Pathogenesis of Multiple Sclerosis. Multiple Sclerosis International, 2021, Article ID: 8825588. [Google Scholar] [CrossRef] [PubMed]
[39] 范烨, 陆云杰, 鲁皓, 等. miRNA-155对调节性T细胞表型和功能的影响[J]. 器官移植, 2014, 5(5): 277-282.
[40] 于佳佳, 唐神结. 巨噬细胞极化在结核病中的作用研究进展[J]. 中华临床感染病杂志, 2019, 12(3): 229-235.
[41] Mann, M., Mehta, A., Zhao, J.L., Lee, K., Marinov, G.K., Garcia-Flores, Y., et al. (2017) An NF-kB-microRNA Regulatory Network Tunes Macrophage Inflammatory Responses. Nature Communications, 8, Article No. 851. [Google Scholar] [CrossRef] [PubMed]
[42] Basler, T., Holtmann, H., Abel, J., Eckstein, T., Baumer, W., Valentin-Weigand, P. and Goethe, R. (2010) Reduced Transcript Stabilization Restricts TNF-alpha Expression in RAW264.7 Macrophages Infected with Pathogenic Mycobacteria: Evidence for an Involvement of Lipomannan. Journal of Leukocyte Biology, 87, 173-183. [Google Scholar] [CrossRef] [PubMed]
[43] (2020) Retraction: Role of EAST-6 in Renal Injury by Regulating mi-croRNA-155 Expression via TLR4/MyD88 Signaling Pathway in Mice with Mycobacterium tuberculosis Infection. Bi-oscience Reports, 40, BSR-20170021_RET.
[44] Kim, M.J., Wainwright, H.C., Locketz, M., Bekker, L.G., Walther, G.B., Dittrich, C., Visser, A., Wang, W., Hsu, F.F., Wiehart, U., Tsenova, L., Kaplan, G. and Russell, D.G. (2010) Ca-seation of Human Tuberculosis Granulomas Correlates with Elevated Host Lipid Metabolism. EMBO Molecular Medi-cine, 2, 258-274. [Google Scholar] [CrossRef] [PubMed]
[45] Huang, Z., Luo, Q., Guo, Y., Chen, J., Xiong, G., Peng, Y., Ye, J. and Li, J. (2015) Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas in Vitro. PLOS ONE, 10, e0129744. [Google Scholar] [CrossRef] [PubMed]
[46] Huang, L., Nazarova, E.V. and Russell, D.G. (2019) Mycobac-terium tuberculosis: Bacterial Fitness within the Host Macrophage. Microbiology Spectrum, 7. [Google Scholar] [CrossRef
[47] Ahluwalia, P.K., Pandey, R.K., Sehajpal, P.K. and Prajapati, V.K. (2017) Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-Survival Foam Cell. Frontiers in Immunology, 8, Article No. 107. [Google Scholar] [CrossRef] [PubMed]
[48] Chinetti, G., Lestavel, S., Bocher, V., Remaley, A.T., Neve, B., Torra, I.P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., Brewer, H.B., Fruchart, J.C., Clavey, V. and Staels, B. (2001) PPAR-Alpha and PPAR-Gamma Activators Induce Cholesterol Removal from Human Macrophage Foam Cells through Stimulation of the ABCA1 Pathway. Nature Medicine, 7, 53-58. [Google Scholar] [CrossRef] [PubMed]
[49] Tian, F.J., An, L.N., Wang, G.K., Zhu, J.Q., Li, Q., Zhang, Y.Y., et al. (2014) Elevated microRNA-155 Promotes Foam Cell Formation by Targeting HBP1 in Atherogenesis. Cardiovascular Research, 103, 100-110. [Google Scholar] [CrossRef] [PubMed]
[50] Nazari-Jahantigh, M., Wei, Y., Noels, H., Akhtar, S., Zhou, Z., Koenen, R.R., Heyll, K., Gremse, F., Kiessling, F., Grommes, J., Weber, C. and Schober, A. (2012) MicroRNA-155 Promotes Atherosclerosis by Repressing Bcl6 in Macrophages. Journal of Clinical Investigation, 122, 4190-4202. [Google Scholar] [CrossRef
[51] Du, F., Yu, F., Wang, Y., Hui, Y., Carnevale, K., Fu, M., Lu, H. and Fan, D. (2014) MicroRNA-155 Deficiency Results in Decreased Macrophage Inflammation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 34, 759-767. [Google Scholar] [CrossRef
[52] Malardo, T., Gardinassi, L.G., Moreira, B., Padilha, É., Lo-renzi, J.C., Soares, L.S., Gembre, A.F., Fontoura, I.C., de Almeida, L.P., de Miranda Santos, I.K., Silva, C.L. and Coe-lho-Castelo, A.A. (2016) MicroRNA Expression Signatures in Lungs of Mice Infected with Mycobacterium tuberculosis. Tuberculosis (Edinb), 101, 151-159. [Google Scholar] [CrossRef] [PubMed]
[53] Golby, P., Villarreal-Ramos, B., Dean, G., Jones, G.J. and Vordermeier, M. (2014) MicroRNA Expression Profiling of PPD-B Stimulated PBMC from M. bovis-Challenged Un-vaccinated and BCG Vaccinated Cattle. Vaccine, 32, 5839-5844. [Google Scholar] [CrossRef] [PubMed]
[54] 蔡青山, 陈园园, 夏强, 等. 肺结核患者外周血miRNA分子表达及临床意义研究[J]. 中华全科医学, 2016, 14(4): 546-548, 588.
[55] 陈雪芳, 许文芳, 王建华. 循环miRNA在活动性肺结核中的表达及其在疾病治疗中的诊疗价值[J]. 中华全科医学, 2017, 15(11): 1941-1943, 1996.
[56] Li, X., He, J., Wang, G. and Sun, J. (2021) Diagnostic Value of microRNA-155 in Active Tuberculosis: A Systematic Review and Meta-Analysis. Medicine (Baltimore), 100, e27869. [Google Scholar] [CrossRef
[57] Kathirvel, M., et al. (2020) Expression Levels of Candidate Circulating microRNAs in Pediatric Tuberculosis. Pathogens and Global Health, 114, 262-270. [Google Scholar] [CrossRef] [PubMed]
[58] 袁秀丽. 结核性脑膜炎患者血浆和脑脊液中miRNAs含量检测及其临床价值评估[J]. 中国现代医学杂志, 2015, 25(31): 22-25.
[59] Hua, Y., et al. (2020) MicroRNA-155 from Sputum as Noninvasive Biomarker for Diagnosis of Active Pulmonary Tuberculosis. Iranian Journal of Basic Medical Sciences, 23, 1419-1425.
[60] Li, M., Cui, J., Niu, W., Huang, J., Feng, T., Sun, B. and Yao, H. (2019) Long Non-Coding PCED1B-AS1 Regulates Macrophage Apoptosis and Autophagy by Sponging miR-155 in Active Tuber-culosis. Biochemical and Biophysical Research Communications, 509, 803-809. [Google Scholar] [CrossRef] [PubMed]
[61] Singh, A.K., Ghosh, M., Kumar, V., Aggarwal, S. and Patil, S.A. (2021) Interplay between miRNAs and Mycobacterium tuberculosis: Diagnostic and Therapeutic Implications. Drug Discovery Today, 26, 1245-1255. [Google Scholar] [CrossRef] [PubMed]
[62] 强锐, 徐俊驰, 宋华峰, 等. 宿主导向疗法治疗结核病的应用机制[J]. 国际流行病学传染病学杂志, 2021, 48(6): 475-478.
[63] Sampath, P., Periyasamy, K.M., Ranganathan, U.D. and Bethunaickan, R. (2021) Monocyte and Macrophage miRNA: Potent Biomarker and Target for Host-Directed Therapy for Tuberculosis. Frontiers in Immunology, 12, Article ID: 667206. [Google Scholar] [CrossRef] [PubMed]