非小细胞肺癌脑转移生物学及分子研究进展
Advances in the Biology and Molecular Study of Brain Metastasis from Non-Small Cell Lung Cancer
DOI: 10.12677/ACM.2022.126804, PDF,   
作者: 邱小雯*：滨州医学院，山东 滨州；朱兴壮*, 董 玮, 张 炜, 李红伟, 宋轶鹏#：青岛大学附属烟台毓璜顶医院放疗科，山东 烟台
关键词: 非小细胞肺癌；脑转移；生物学；分子；研究进展；Non-Small Cell Lung Cancer； Brain Metastasis； Biology； Molecular； Research Progress
摘要: 随着医疗技术的进步，非小细胞肺癌(non-small cell lung cancer, NSCLC)患者生存期延长，脑转移(brain metastases, BM)成为其重要的治疗障碍。肿瘤的转移是一个多步骤过程中，更好地了解疾病转移的发病机制将有助于我们确定合适的治疗策略，从而避免脑转移的发生，对患者的预后极其重要。本文就非小细胞肺癌脑转移生物学和分子研究的最新发现作一综述。
Abstract: With the advancement of medical technology, patients with non-small cell lung cancer (NSCLC) have prolonged survival and brain metastases (BM) have become an important therapeutic obstacle for them. Tumor metastasis is a multistep process, and a better understanding of the pathogenesis of disease metastasis will help us determine the appropriate treatment strategy to avoid brain me-tastases, which is extremely important for patient prognosis. In this paper, we present a review of recent findings on the biology and molecular studies of brain metastasis in non-small cell lung can-cer.
文章引用：邱小雯, 朱兴壮, 董玮, 张炜, 李红伟, 宋轶鹏. 非小细胞肺癌脑转移生物学及分子研究进展[J]. 临床医学进展, 2022, 12(6): 5561-5568. https://doi.org/10.12677/ACM.2022.126804

参考文献

[1] Jin, J., et al. (2013) Brain Metastases as the First Symptom of Lung Cancer: A Clinical Study from an Asian Medical Center. Journal of Cancer Research and Clinical Oncology, 139, 403-408. [Google Scholar] [CrossRef] [PubMed]
[2] Svokos, K.A., Salhia, B. and Toms, S.A. (2014) Molecular Biol-ogy of Brain Metastasis. International Journal of Molecular Sciences, 15, 9519-9530. [Google Scholar] [CrossRef] [PubMed]
[3] Winkler, F. (2015) The Brain Metastatic Niche. Journal of Molecular Medicine (Berlin), 93, 1213-1220. [Google Scholar] [CrossRef] [PubMed]
[4] Luzzi, K.J., et al. (1998) Multistep Nature of Metastatic Ineffi-ciency: Dormancy of Solitary Cells after Successful Extravasation and Limited Survival of Early Micrometastases. The American Journal of Pathology, 153, 865-873. [Google Scholar] [CrossRef] 
[5] Palmieri, D., et al. (2007) The Biology of Metastasis to a Sanctuary Site. Clinical Cancer Research, 13, 1656-1662. [Google Scholar] [CrossRef] 
[6] Deeken, J.F. and Löscher, W. (2007) The Blood-Brain Bar-rier and Cancer: Transporters, Treatment, and Trojan Horses. Clinical Cancer Research, 13, 1663-1674. [Google Scholar] [CrossRef] 
[7] Abbott, N.J., Rönnbäck, L. and Hansson, E. (2006) Astro-cyte-Endothelial Interactions at the Blood-Brain Barrier. Nature Reviews Neuroscience, 7, 41-53. [Google Scholar] [CrossRef] [PubMed]
[8] Preusser, M., et al. (2012) Brain Metastases: Pathobiology and Emerging Targeted Therapies. Acta Neuropathologica, 123, 205-222. [Google Scholar] [CrossRef] [PubMed]
[9] Eichler, A.F., et al. (2011) The Biology of Brain Metastases-Translation to New Therapies. Nature Reviews Clinical Oncology, 8, 344-356. [Google Scholar] [CrossRef] [PubMed]
[10] Grinberg-Rashi, H., et al. (2009) The Expression of Three Genes in Primary Non-Small Cell Lung Cancer Is Associated with Metastatic Spread to the Brain. Clinical Cancer Re-search, 15, 1755-1761. [Google Scholar] [CrossRef] 
[11] Yoo, J., et al. (2012) Immunohistochemical Expression of DCUN1D1 in Non-Small Cell Lung Carcinoma: Its Relation to Brain Metastasis. Cancer Research and Treatment, 44, 57-62. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, H., et al. (2019) Genes Associated with Increased Brain Metastasis Risk in Non-Small Cell Lung Cancer: Comprehensive Genomic Profiling of 61 Resected Brain Metas-tases versus Primary Non-Small Cell Lung Cancer (Guangdong Association Study of Thoracic Oncology 1036). Cancer, 125, 3535-3544. [Google Scholar] [CrossRef] [PubMed]
[13] Desgrosellier, J.S. and Cheresh, D.A. (2010) Integrins in Cancer: Biological Implications and Therapeutic Opportunities. Nature Reviews Cancer, 10, 9-22. [Google Scholar] [CrossRef] [PubMed]
[14] Yoshimasu, T., et al. (2004) Increased Expression of Integrin α3β1 in Highly Brain Metastatic Subclone of a Human Non-Small Cell Lung Cancer Cell Line. Cancer Science, 95, 142-148. [Google Scholar] [CrossRef] [PubMed]
[15] Sipos, E., et al. (2012) Proinflammatory Adhesion Mol-ecules Facilitate Polychlorinated Biphenyl-Mediated Enhancement of Brain Metastasis Formation. Toxicological Sciences, 126, 362-371. [Google Scholar] [CrossRef] [PubMed]
[16] Münsterberg, J., et al. (2020) ALCAM Contributes to Brain Metastasis Formation in Non-Small-Cell Lung Cancer through Interaction with the Vascular Endothelium. Neu-ro-Oncology, 22, 955-966. [Google Scholar] [CrossRef] [PubMed]
[17] Jiang, W.G. (1996) E-cadherin and Its Associated Protein Catenins, Cancer Invasion and Metastasis. British Journal of Surgery, 83, 437-446. [Google Scholar] [CrossRef] [PubMed]
[18] Kreiseder, B., et al. (2013) α-Catulin Downregulates E-cadherin and Promotes Melanoma Progression and Invasion. International Journal of Cancer, 132, 521-530. [Google Scholar] [CrossRef] [PubMed]
[19] Yoo, J.Y., et al. (2012) E-cadherin as a Predictive Marker of Brain Metasta-sis in Non-Small-Cell Lung Cancer, and Its Regulation by Pioglitazone in a Preclinical Model. Journal of Neu-ro-Oncology, 109, 219-227. [Google Scholar] [CrossRef] [PubMed]
[20] London, N.R., Whitehead, K.J. and Li, D.Y. (2009) Endogenous Endothelial Cell Signaling Systems Maintain Vascular Stability. Angiogenesis, 12, 149-158. [Google Scholar] [CrossRef] [PubMed]
[21] Yano, S., et al. (2000) Expression of Vascular Endothelial Growth Factor Is Necessary but Not Sufficient for Production and Growth of Brain Metastasis. Cancer Research, 60, 4959-4967.
[22] Jubb, A.M., et al. (2011) Vascular Phenotypes in Primary Non-Small Cell Lung Carcinomas and Matched Brain Metastases. British Journal of Cancer, 104, 1877-1881. [Google Scholar] [CrossRef] [PubMed]
[23] Keeley, E.C., Mehrad, B. and Strieter, R.M. (2010) CXC Chemokines in Cancer Angiogenesis and Metastases. Advances in Cancer Research, 106, 91-111. [Google Scholar] [CrossRef] 
[24] Fokas, E., Steinbach, J.P. and Rödel, C. (2013) Biology of Brain Metastases and Novel Targeted Therapies: Time to Translate the Research. Biochimica et Biophysica Acta, 1835, 61-75. [Google Scholar] [CrossRef] [PubMed]
[25] Paratore, S., et al. (2011) CXCR4 and CXCL12 Immuno-reactivities Differentiate Primary Non-Small-Cell Lung Cancer with or without Brain Metastases. Cancer Biomarkers, 10, 79-89. [Google Scholar] [CrossRef] 
[26] Rizzo, A., et al. (2015) Melanoma Cells Homing to the Brain: An in Vitro Model. BioMed Research International, 2015, Article ID: 476069. [Google Scholar] [CrossRef] [PubMed]
[27] Liu, H., et al. (2012) The Role of MMP-1 in Breast Cancer Growth and Metastasis to the Brain in a Xenograft Model. BMC Cancer, 12, Article No. 583. [Google Scholar] [CrossRef] [PubMed]
[28] Hu, L., et al. (2010) Biological Characteristics of a Specific Brain Metastatic Cell Line Derived from Human Lung Adenocarcinoma. Medical Oncology, 27, 708-714. [Google Scholar] [CrossRef] [PubMed]
[29] Shintani, Y., et al. (2004) Overexpression of ADAM9 in Non-Small Cell Lung Cancer Correlates with Brain Metastasis. Cancer Research, 64, 4190-4196. [Google Scholar] [CrossRef] 
[30] Chen, L.T., et al. (2012) MicroRNA-378 Is Associated with Non-Small Cell Lung Cancer Brain Metastasis by Promoting Cell Migration, Invasion and Tumor Angiogenesis. Medical Oncology, 29, 1673-1680. [Google Scholar] [CrossRef] [PubMed]
[31] Arora, S., et al. (2011) MicroRNA-328 Is Associated with (Non-Small) Cell Lung Cancer (NSCLC) Brain Metastasis and Mediates NSCLC Migration. International Journal of Cancer, 129, 2621-2631. [Google Scholar] [CrossRef] [PubMed]
[32] Wei, C., et al. (2019) MicroRNA-330-3p Pro-motes Brain Metastasis and Epithelial-Mesenchymal Transition via GRIA3 in Non-Small Cell Lung Cancer. Aging (Al-bany NY), 11, 6734-6761. [Google Scholar] [CrossRef] [PubMed]
[33] Wang, H., et al. (2019) N6-Methyladenosine Induced miR-143-3p Promotes the Brain Metastasis of Lung Cancer via Regulation of VASH1. Molecular Cancer, 18, 181. [Google Scholar] [CrossRef] [PubMed]
[34] Mok, T.S., et al. (2009) Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma. The New England Journal of Medicine, 361, 947-957. [Google Scholar] [CrossRef] 
[35] Ouyang, W., et al. (2020) Risk Factors of Metachronous Brain Me-tastasis in Patients with EGFR-Mutated Advanced Non-Small Cell Lung Cancer. BMC Cancer, 20, Article No. 699. [Google Scholar] [CrossRef] [PubMed]
[36] Burel-Vandenbos, F., et al. (2013) EGFR Mutation Status in Brain Metastases of Non-Small Cell Lung Carcinoma. Journal of Neuro-Oncology, 111, 1-10. [Google Scholar] [CrossRef] [PubMed]
[37] Hsu, F., et al. (2016) EGFR Mutation Status on Brain Metastases from Non-Small Cell Lung Cancer. Lung Cancer, 96, 101-107. [Google Scholar] [CrossRef] [PubMed]
[38] Bhatt, V.R., et al. (2017) Epidermal Growth Factor Receptor Mutational Status and Brain Metastases in Non-Small-Cell Lung Cancer. Journal of Global Oncology, 3, 208-217. [Google Scholar] [CrossRef] 
[39] Rangachari, D., et al. (2015) Brain Metastases in Patients with EGFR-Mutated or ALK-Rearranged Non-Small-Cell Lung Cancers. Lung Cancer, 88, 108-111. [Google Scholar] [CrossRef] [PubMed]
[40] Gainor, J.F., et al. (2013) The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology, 8, 1570-1573. [Google Scholar] [CrossRef] 
[41] Okamoto, H., et al. (1993) Intradural Parenchymal Involve-ment in the Spinal Subarachnoid Space Associated with Primary Lung Cancer. Cancer, 72, 2583-2588. [Google Scholar] [CrossRef] 
[42] Grossman, S.A. and Krabak, M.J. (1999) Leptomeningeal Carcinomatosis. Cancer Treatment Reviews, 25, 103-119. [Google Scholar] [CrossRef] [PubMed]

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