干细胞与颅脑创伤治疗的研究进展

The Research Progress of Stem Cells and Treatment of Traumatic Brain Injury

摘要: 脑创伤(traumatic brain injury, TBI)是生活中十分常见的多发病，因TBI伤残率和死亡率在各类创伤性疾病中均位列首位，给社会和家庭带来了十分沉重的负担，给TBI病人的生命质量带来了严重影响，当前已成为全球严重的公共卫生难题。降低TBI患者死亡率、致残率，提高患者的生存质量，一直是广大医务工作者和科研人员面对的共同问题。TBI缺乏有效的特效疗法，近年来，随着干细胞技术的不断发展，在损伤脑组织再生方面越来越受关注，因其治疗效果好、无显著并发症、创伤小、易被患者接受，应用前景广阔。间充质–干细胞(mesenchymal stem cells, MSCs)是来源多、用途广、易获取，体外容易实现大量扩增，分化能力强，潜能的种子细胞，MSCs可在短时间内获得治疗数量的细胞且免疫原性低，具有得天独厚的治疗优势，其被广泛用于损伤脑组织再生修复改善神经功能。

Abstract: Traumatic brain injury (TBI) is a very relatively common frequently-occurring disease. The disabil-ity rate and mortality rate of TBI rank first among all kinds of traumatic diseases, bringing a heavy burden to society and family and seriously affecting the patient’s health. Quality of life has become a serious global public health problem. Reducing the mortality and morbidity of TBI patients and improving the quality of life of patients have always been a common problem faced by the majority of medical workers and researchers. TBI lacks effective specific treatments. In recent years, with the continuous development of stem cell technology, more and more attention has been paid to the regeneration of damaged brain tissue, showing its obvious advantages. Mesenchymal stem cells (MSCs) are seed cells that can be easily isolated, can be easily expanded in vitro, and have mul-ti-directional differentiation potential. It has unique therapeutic advantages and is widely used for regeneration and repair of damaged brain tissue to improve neurological function.